methyl (2S)-2-[[2-[2-[[2-[2-[2-[[(2S)-1-methoxy-4-methylsulfanyl-1-oxobutan-2-yl]amino]-2-oxoacetyl]anilino]-2-oxoacetyl]amino]phenyl]-2-oxoacetyl]amino]-4-methylsulfanylbutanoate | 1021907-00-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[[2-[2-[[2-[2-[2-[[(2S)-1-methoxy-4-methylsulfanyl-1-oxobutan-2-yl]amino]-2-oxoacetyl]anilino]-2-oxoacetyl]amino]phenyl]-2-oxoacetyl]amino]-4-methylsulfanylbutanoate
• CAS: 1021907-00-5
• 化学式: C₃₀H₃₄N₄O₁₀S₂
• 分子量: 674.753
• InChiKey: ZRYVISGIXJHLCN-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  46
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  254
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  L-蛋氨酸甲酯盐酸盐 、 N,N'-oxalyl-bis-isatin 在 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以30%的产率得到methyl (2S)-2-[[2-[2-[[2-[2-[2-[[(2S)-1-methoxy-4-methylsulfanyl-1-oxobutan-2-yl]amino]-2-oxoacetyl]anilino]-2-oxoacetyl]amino]phenyl]-2-oxoacetyl]amino]-4-methylsulfanylbutanoate
  参考文献：
  名称：

  Synthesis of anti-bacterial peptidomimetics derived from N-acylisatins

  摘要：

  An efficient synthetic strategy to mono- and bis-glyoxylamide derivatives via the reaction of N-acylisatins with a range of amino acids has been developed. Using this strategy, a series of new peptidomimetics have been synthesized. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.03.007

文献信息

• Synthesis of anti-bacterial peptidomimetics derived from N-acylisatins
  作者：Wai Ching Cheah、David StC Black、Wai Kean Goh、Naresh Kumar

  DOI：10.1016/j.tetlet.2008.03.007

  日期：2008.4

  An efficient synthetic strategy to mono- and bis-glyoxylamide derivatives via the reaction of N-acylisatins with a range of amino acids has been developed. Using this strategy, a series of new peptidomimetics have been synthesized. (c) 2008 Elsevier Ltd. All rights reserved.
• Facile ring-opening of N-acylisatins for the development of novel peptidomimetics
  作者：Wai Ching Cheah、Kasey Wood、David StC Black、Naresh Kumar

  DOI：10.1016/j.tet.2011.07.036

  日期：2011.9

  A range of novel mono- and bis-glyoxylamide peptidomimetics were prepared via the facile ring-opening of N-acylisatins with amino acids and peptide derivatives. The ring-opening of N-acylisatins with dipeptides and tripeptides was discovered to be the most efficient strategy for the synthesis of second and third generation glyoxylamides. (C) 2011 Elsevier Ltd. All rights reserved.