4-amino-6-(4-methoxyphenyl)-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide | 1350887-37-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 4-amino-6-(4-methoxyphenyl)-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide
• 英文别名: 4-amino-7-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(4-methoxyphenyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide
• CAS: 1350887-37-4
• 化学式: C₁₉H₂₁N₅O₆
• 分子量: 415.406
• InChiKey: HRCMXTZGXUXQJM-XFDQDIGDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  179
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  L-木糖 在 吡啶 、 ammonium hydroxide 、 N,O-双三甲硅基乙酰胺 、 硫酸 、 双氧水 、 sodium methylate 、 palladium diacetate 、 potassium carbonate 、 溶剂黄146 、 三苯基膦 作用下， 以 1,4-二氧六环 、 甲醇 、 乙腈 为溶剂， 反应 32.67h， 生成 4-amino-6-(4-methoxyphenyl)-7-(β-L-xylofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide
  参考文献：
  名称：

  Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro

  摘要：

  A series of purine nucleoside analogues bearing an aryl and hetaryl group in position 6 were prepared and their biological activities were assessed by in vitro CDK1/Cyclin B1 and CDK2/Cyclin A2 kinase assay. From the synthesized chemicals, three Xylocydine derivatives 3h, 3i, and 3j exhibited specific inhibitory activities on CDK2/Cyclin A2 with IC50 values of 4.6, 4.8, and 55 mu M, respectively. Those three compounds all induced G1/S phase arrest in Human epithelial carcinoma cell line (HeLa), and the results suggested they may inhibit CDK2 activity in vitro. Furthermore, molecular modeling study, their docking into Cyclin Dependant Kinase 2 (CDK2) active site showed high docking scores. Taken together, these data suggest that, those three compounds are good inhibitors of CDK2 for studying this kinase signal transduction pathway in cell system. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.003

文献信息

• Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro
  作者：Chuan Xiao、Chao Sun、Weiwei Han、Feng Pan、Zhu Dan、Yu Li、Zhi-Guang Song、Ying-Hua Jin

  DOI：10.1016/j.bmc.2011.10.003

  日期：2011.12

  A series of purine nucleoside analogues bearing an aryl and hetaryl group in position 6 were prepared and their biological activities were assessed by in vitro CDK1/Cyclin B1 and CDK2/Cyclin A2 kinase assay. From the synthesized chemicals, three Xylocydine derivatives 3h, 3i, and 3j exhibited specific inhibitory activities on CDK2/Cyclin A2 with IC50 values of 4.6, 4.8, and 55 mu M, respectively. Those three compounds all induced G1/S phase arrest in Human epithelial carcinoma cell line (HeLa), and the results suggested they may inhibit CDK2 activity in vitro. Furthermore, molecular modeling study, their docking into Cyclin Dependant Kinase 2 (CDK2) active site showed high docking scores. Taken together, these data suggest that, those three compounds are good inhibitors of CDK2 for studying this kinase signal transduction pathway in cell system. (C) 2011 Elsevier Ltd. All rights reserved.