4-(甲基硫烷基)-7-(5-O-磷羧基五呋喃糖基)-7H-吡咯并[2,3-d]嘧啶 | 16684-22-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 中文名称: 4-(甲基硫烷基)-7-(5-O-磷羧基五呋喃糖基)-7H-吡咯并[2,3-d]嘧啶
• 英文名称: [3,4-Dihydroxy-5-(4-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)oxolan-2-yl]methyl dihydrogen phosphate
• CAS: 16684-22-3
• 化学式: C₁₂H₁₆N₃O₇PS
• 分子量: 377.31
• InChiKey: RDLNVHQUQZBWDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• KINASE PROTEIN BINDING INHIBITORS
  申请人：Hochwald Steven N.

  公开号：US20120107323A1

  公开（公告）日：2012-05-03

  The invention provides compounds capable of treating a subject suffering from or being susceptible to a cell proliferative disorder (especially, cancer), methods of identifying and using the compounds, pharmaceutical compositions and kits thereof.
• [EN] KINASE PROTEIN BINDING INHIBITORS<br/>[FR] INHIBITEURS DE LA LIAISON À UNE PROTÉINE KINASE
  申请人：UNIV FLORIDA

  公开号：WO2010104598A2

  公开（公告）日：2010-09-16

  The invention provides compounds capable of treating a subject suffering from or being susceptible to a cell proliferative disorder (especially, cancer), methods of identifying and using the compounds, pharmaceutical compositions and kits thereof.