1'-ethyl-4,7-dihydrospiro[[1,3]dioxepine-2,3'-indolin]-2'-one | 1632247-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1'-ethyl-4,7-dihydrospiro[[1,3]dioxepine-2,3'-indolin]-2'-one
• 英文别名: 1'-Ethylspiro[4,7-dihydro-1,3-dioxepine-2,3'-indole]-2'-one；1'-ethylspiro[4,7-dihydro-1,3-dioxepine-2,3'-indole]-2'-one
• CAS: 1632247-55-2
• 化学式: C₁₄H₁₅NO₃
• 分子量: 245.278
• InChiKey: AEIFKXMMQJPVSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-乙基-1H-吲哚-2,3-二酮 在 Grubbs catalyst first generation 、 四(三苯基膦)钯 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 15.0h， 生成 1'-ethyl-4,7-dihydrospiro[[1,3]dioxepine-2,3'-indolin]-2'-one
  参考文献：
  名称：

  Palladium-Catalyzed Interceptive Decarboxylative Addition of Allyl Car­bonates with Carbonyl Group

  摘要：

  The first palladium-catalyzed interceptive decarboxylative 1,4-addition of allyl carbonates with squarates is reported. Interestingly, the C-3 carbonyl group of N-substituted isatins undergoes smooth decarboxylative 1,2-addition with allyl carbonates. This transformation offers a straightforward method for the synthesis of spiro-oxepane-fused 2-oxindole.

  DOI：

  10.1055/s-0033-1341201

文献信息

• Palladium-Catalyzed Interceptive Decarboxylative Addition of Allyl Car­bonates with Carbonyl Group
  作者：K. Radhakrishnan、Yoshinori Yamamoto、T. Baiju、Nayana Joseph、Jainu Ajit、Praveen Prakash、Sunil Varughese

  DOI：10.1055/s-0033-1341201

  日期：——

  The first palladium-catalyzed interceptive decarboxylative 1,4-addition of allyl carbonates with squarates is reported. Interestingly, the C-3 carbonyl group of N-substituted isatins undergoes smooth decarboxylative 1,2-addition with allyl carbonates. This transformation offers a straightforward method for the synthesis of spiro-oxepane-fused 2-oxindole.