N,N-dimethyl-4,5-dimethoxy-2-nitrobenzamide | 349411-81-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dimethyl-4,5-dimethoxy-2-nitrobenzamide
• 英文别名: 4,5-dimethoxy-N,N-dimethyl-2-nitrobenzamide
• CAS: 349411-81-0
• 化学式: C₁₁H₁₄N₂O₅
• mdl: MFCD02859456
• 分子量: 254.243
• InChiKey: UISDPGXDMJXTJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  84.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-4,5-dimethoxy-2-nitrobenzamide 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 2-Amino-4,5-dimethoxy-N,N-dimethyl-benzamide
  参考文献：
  名称：

  Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

  摘要：

  A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00717-4
• 作为产物：
  描述：

  6-硝基藜芦酸 、 二甲胺 在 三乙胺 、 二苯基次膦酰氯 作用下， 以 氯仿 为溶剂， 生成 N,N-dimethyl-4,5-dimethoxy-2-nitrobenzamide
  参考文献：
  名称：

  Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

  摘要：

  A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00717-4

文献信息

• 一种三氯氧磷促进的酰胺类化合物的合成方法
  申请人：中国人民解放军63975部队

  公开号：CN106187803A

  公开（公告）日：2016-12-07

  本发明涉及一种三氯氧磷促进的酰胺类化合物的合成方法。本发明的合成方法是以羧酸为其中一反应物，以另一反应物(N，N‑二烷基甲酰胺)为溶剂，加入1当量的三氯氧磷，制备酰胺化合物。反应底物廉价易得，性质稳定、毒性小，反应迅速，条件温和，对不同官能团的底物具有广泛的适用性。本发明高效构建的酰胺类化合物是很多药物、生物活性分子和天然产物的重要分子骨架，本发明所述的合成方法为这类化合物的合成提供了一个广泛适用的制备方法。
• POCl₃ promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and <i>N,N</i>-disubstituted formamides
  作者：Xiaojing Bi、Junchen Li、Enxue Shi、Yu Li、Ying Liu、Hongmei Wang、Junhua Xiao

  DOI：10.1080/10426507.2018.1539991

  日期：2019.3.4

  Abstract Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory

  摘要在此我们报告了一种稳健且合成有用的无催化剂胺化方法，该方法通过使用 POCl3 作为促进剂将羧酸和 N 取代甲酰胺偶联。具有多种取代基的多功能酰胺仅在 1 小时内就以良好到极好的收率制备。甚至多取代的芳族羧酸也可以得到令人满意的结果。图形概要
• Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
  作者：Haruhisa Ogita、Yoshiaki Isobe、Haruo Takaku、Rena Sekine、Yuso Goto、Satoru Misawa、Hideya Hayashi

  DOI：10.1016/s0960-894x(00)00717-4

  日期：2001.2

  A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.