N-(N-benzoyl-glycyl)-leucine | 60889-69-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(N-benzoyl-glycyl)-leucine
• 英文别名: N-(N-Benzoyl-glycyl)-leucin；2-[(2-Benzamidoacetyl)amino]-4-methylpentanoic acid
• CAS: 60889-69-2
• 化学式: C₁₅H₂₀N₂O₄
• 分子量: 292.335
• InChiKey: OYKCZXMDOFUNRX-UHFFFAOYSA-N

物化性质

• 沸点：
  606.1±40.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢溴酸 、 溶剂黄146 作用下， 生成 N-(N-benzoyl-glycyl)-leucine
  参考文献：
  名称：

  Taschner et al., Roczniki Chemii, 1958, vol. 32, p. 1107,1110,1112

  摘要：

  DOI：

文献信息

• 4-Alkoxy-2-hydroxybenzaldehyde (AHB):  A Versatile Aldehyde Linker for Solid-Phase Synthesis of C-Terminal Modified Peptides and Peptidomimetics
  作者：Toru Okayama、Andrew Burritt、Victor J. Hruby

  DOI：10.1021/ol000048h

  日期：2000.6.1

  [reaction: see text] A new and versatile 4-alkoxy-2-hydroxybenzaldehyde (AHB) linker for solid-phase syntheses is described. Acylation of the polymer-bound secondary amine obtained from reductive amination of the aldehyde in the AHB linker showed good reactivity. Following acylation of the phenolic hydroxyl group, the resulting carboxamide resin was stable to treatment with 95% TFA. The O-acyl functional

  [反应：见正文]描述了一种用于固相合成的新型多功能4-烷氧基-2-羟基苯甲醛（AHB）接头。由AHB接头中醛的还原胺化反应获得的与聚合物结合的仲胺的酰化反应显示出良好的反应性。酚羟基的酰化后，所得羧酰胺树脂对于用95％TFA处理是稳定的。用20％哌啶除去O-酰基官能团，并通过TFA处理从树脂上裂解所需的化合物。
• DIRECT ACYLATION OF α-AMINO ACIDS AND OF α-HYDROXY ACID DERIVATIVES
  作者：EDWARD RONWIN

  DOI：10.1021/jo01130a002

  日期：1953.2
• Effect of acute elevation of IGF-I on circulating GH, TSH, insulin, IGF-II and IGFBP-3 levels in non-endocrine short stature (NESS)
  作者：Kunihiko Hanew、A. Tanaka

  DOI：10.1007/bf03343801

  日期：2001.1

  It is not clear whether acute and slight elevation of serum IGF-I, which does not affect blood glucose levels, modulates circulating GH levels. To clarify this, small doses of recombinant human IGF-I (rhIGF-I, 5 microg/kg, i.v.) were administered as a bolus to 10 children with non-endocrine short stature (NESS) (5 males and 5 females, 11.2+/-0.7 yr old) after an overnight fast. Physiological saline was administered intravenously to sex- and age-matched NESS controls (5 males and 5 females, 10.9+/-0.7 yr old). The changes of serum GH, TSH, PRL, IGF-I, IGF-II, IGFBP-3, T4, T3 and plasma glucose levels after the administration were compared to those of the control subjects. Serum IGF-I levels increased significantly from 15 to 150 min after injection compared to those in the control group. The peak value was observed at 15 min (delta increment, 74.6+/-11.8 microg/l). At 15 min after the injection, serum insulin was suppressed significantly (p<0.05), although plasma glucose levels were not modified significantly. Serum TSH showed a significant decrease by rhIGF-I at 15 min and 60 min, whereas serum T4 and T3 levels were not modified. Serum GH was also significantly suppressed at 60 min (p<0.02) and showed a rebound increase at 120 min (p<0.05). Serum IGFBP-3 levels after rhIGF-I were higher than controls at 90 min and 150 min. No significant changes of serum PRL, IGF-II, (IGF-I plus IGF-II)/IGFBP-3 ratios were observed after the IGF-I injection compared to controls. These results indicate that circulating IGF-I is a physiological regulator of GH secretion in normal children, since the changes of IGF-I after the small doses of rhlGF-I administration were within physiological ranges and did not affect plasma glucose levels.
• [EN] CARBOXYPEPTIDASE B RELATED POLYPEPTIDES AND METHODS OF USE<br/>[FR] POLYPEPTIDES ASSOCIES A LA CARBOXYPEPTIDASE B ET METHODES D'UTILISATION
  申请人：SCHERING AG

  公开号：WO2004020587A2

  公开（公告）日：2004-03-11

  Recombinant TAFI polypeptide mutants, as well as the polynucleotides encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in methods of screening for potential therapeutic agents, substrates, inhibitors or enhancers of carboxypeptidases.
• Taschner et al., Roczniki Chemii, 1958, vol. 32, p. 1107,1110,1112
  作者：Taschner et al.

  DOI：——

  日期：——