3-phenyl-4-t-butylpyrazole | 134792-33-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-phenyl-4-t-butylpyrazole
• 英文别名: 4-tert-butyl-5-phenyl-1H-pyrazole
• CAS: 134792-33-9
• 化学式: C₁₃H₁₆N₂
• 分子量: 200.283
• InChiKey: OHLQOUDDEVYBSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-3,3-dimethyl-1-(5-phenyltetrazol-2-yl)but-1-ene 以 甲醇 为溶剂， 反应 1.5h， 以99%的产率得到3-phenyl-4-t-butylpyrazole
  参考文献：
  名称：

  Moody, Christopher J.; Rees, Charles W.; Young, Richard G., Journal of the Chemical Society. Perkin transactions I, 1991, # 2, p. 329 - 333

  摘要：

  DOI：

文献信息

• HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
  申请人：Chuaqui Claudio

  公开号：US20120040951A1

  公开（公告）日：2012-02-16

  The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

  本发明提供了式（I）的化合物，可用作Raf蛋白激酶的抑制剂。本发明还提供了其组合物以及治疗Raf介导疾病的方法。
• NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Bolea Christelle

  公开号：US20110257179A1

  公开（公告）日：2011-10-20

  The present invention relates to novel compounds of Formula (I), wherein M, P, A and (B) n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.

  本发明涉及公式（I）的新化合物，其中M，P，A和（B）n如公式（I）中所定义；发明化合物是代谢型谷氨酸受体-亚型4（“mGluR4”）的调节剂，对于治疗或预防中枢神经系统疾病以及其他由mGluR4受体调节的疾病有用。本发明还涉及制药组合物以及使用这种化合物制造药物的用途，以及使用这种化合物预防和治疗涉及mGluR4的疾病的用途。
• MOODY, CHRISTOPHER J.;REES, CHARLES W.;YOUNG, RICHARD G., J. CHEM. SOC. PERKIN TRANS. PT 1,(1991) N, C. 329-333
  作者：MOODY, CHRISTOPHER J.、REES, CHARLES W.、YOUNG, RICHARD G.

  DOI：——

  日期：——
• SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
  申请人：GENFLEET THERAPEUTICS (SHANGHAI) INC.

  公开号：US20220177462A1

  公开（公告）日：2022-06-09

  A substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the use of same in the preparation of a drug for treating a RIPK1-related diseases or conditions.
• US9073907B2
  申请人：——

  公开号：US9073907B2

  公开（公告）日：2015-07-07