(S)-(+)-hexahydromandelamide | 362519-24-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-(+)-hexahydromandelamide
• 英文别名: Rqa6PK7ptv；(2S)-2-cyclohexyl-2-hydroxyacetamide
• CAS: 362519-24-2
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: MWYCEGYVPYAVBR-ZETCQYMHSA-N

物化性质

• 沸点：
  333.2±25.0 °C(Predicted)
• 密度：
  1.120±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-(+)-hexahydromandelamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以66%的产率得到(S)-(+)-1-amino-(1-cyclohexyl)ethanol
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9
• 作为产物：
  描述：

  (S)-α-羟基环己烷乙酸 在 氨 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 66.0h， 生成 (S)-(+)-hexahydromandelamide
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9

文献信息

• [EN] NOVEL ANTIBACTERIAL 3"-DERIVATIVES OF 4,6-DISUBSTITUTED 2,5-DIDEOXYSTREPTAMINE AMINOGLYCOSIDE ANTIBIOTICS<br/>[FR] NOUVEAUX DÉRIVÉS 3" ANTIBACTÉRIENS D'ANTIBIOTIQUES À BASE D'AMINOGLYCOSIDE 2,5-DIDÉSOXYSTREPTAMINE 4,6-DISUBSTITUÉS
  申请人：AGILEBIOTICS B V

  公开号：WO2020115190A1

  公开（公告）日：2020-06-11

  The present invention relates to novel aminoglycoside compounds having antimicrobial properties and being suitable, for example, as therapeutic agents for use in the treatment of mammalian disease and in particular to novel therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. The invention further relates to compounds for use in the treatment of diseases whose treatment is made otherwise difficult due to antibiotic-class-related bacterial resistance and provides novel therapeutic agents suitable for use in the treatment of multidrug-resistant (MDR) infections.

  本发明涉及具有抗微生物特性的新型氨基糖苷化合物，适用于作为治疗剂，例如用于治疗哺乳动物疾病的治疗剂，特别是适用于治疗哺乳动物微生物感染的新型治疗剂。本发明还涉及包含所述治疗剂的药物组合物在治疗哺乳动物的医疗状况中的使用，特别是在治疗微生物感染中的使用。本发明的治疗剂和药物组合物在治疗与抗生素耐药微生物相关的疾病方面具有特殊意义。本发明还涉及用于治疗因抗生素类相关细菌耐药而导致治疗变得困难的疾病的化合物，并提供适用于治疗多药耐药（MDR）感染的新型治疗剂。
• [EN] SERINE REPLACEMENT POLYMYXIN ANALOGUES USEFUL AS ANTIBIOTIC POTENTIATORS<br/>[FR] ANALOGUES DE POLYMYXINE DE REMPLACEMENT DE SÉRINE UTILES EN TANT QUE POTENTIALISATEURS D'ANTIBIOTIQUE
  申请人：SPERO OPCO

  公开号：WO2017189868A1

  公开（公告）日：2017-11-02

  The disclosure provides compounds of the formula I or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables R1 and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering a therapeutically effective amount of the antibacterial agent and a compound of formula I to a patient infected with the bacteria, simultaneously or sequentially.

  该披露提供了公式I或其互变异构体的化合物，或者是上述任一化合物的药用盐。变量R1和R2在披露中有定义。该披露还包括包括公式I化合物以及至少一种药用载体的药物组合物。该披露还包括一种使细菌对抗菌剂敏感的方法，包括向感染有该细菌的患者同时或顺序地给予抗菌剂和公式I化合物的治疗有效量。
• 1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines
  作者：Tommaso Mecca、Stefano Superchi、Egidio Giorgio、Carlo Rosini

  DOI：10.1016/s0957-4166(01)00199-9

  日期：2001.5

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.