(S)-(+)-1-amino-(1-cyclohexyl)ethanol | 84619-58-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (S)-(+)-1-amino-(1-cyclohexyl)ethanol
• 英文别名: (+)-2-cyclohexyl-2-hydroxyethylamine；(S)-(-)-2-amino-1-cyclohexylethanol；(1S)-2-amino-1-cyclohexylethan-1-ol；(1S)-2-amino-1-cyclohexylethanol
• CAS: 84619-58-9
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: MSIAFRBGOYFCND-MRVPVSSYSA-N

物化性质

• 沸点：
  273.8±13.0 °C(Predicted)
• 密度：
  0.999±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-(+)-1-amino-(1-cyclohexyl)ethanol 、 (S)-2,2'-双(溴甲基)-1,1'-联萘 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以92%的产率得到(aS,S)-(+)-2,2'-[2-(2-cyclohexyl-2-hydroxyethyl)-2-azapropane-1,3-diyl]-1,1'-binaphthalene
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9
• 作为产物：
  描述：

  (S)-α-羟基环己烷乙酸 在 lithium aluminium tetrahydride 、 氨 作用下， 以 四氢呋喃 、 乙醇 、 氯仿 为溶剂， 反应 114.0h， 生成 (S)-(+)-1-amino-(1-cyclohexyl)ethanol
  参考文献：
  名称：

  1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines

  摘要：

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00199-9

文献信息

• Application of optically active 1,2-diol monotosylates for synthesis of β-azido and β-amino alcohols with very high enantiomeric purity. Synthesis of enantiopure (R)-octopamine, (R)-tembamide and (R)-aegeline
  作者：Byung Tae Cho、Sang Kyu Kang、Sung Hye Shin

  DOI：10.1016/s0957-4166(02)00322-1

  日期：2002.6
• BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
  申请人：Agenebio, Inc.

  公开号：EP3810611A1

  公开（公告）日：2021-04-28
• 1,1′-Binaphthylazepine-based ligands for asymmetric catalysis. Part 1: Preparation and characterization of some new aminoalcohols and diamines
  作者：Tommaso Mecca、Stefano Superchi、Egidio Giorgio、Carlo Rosini

  DOI：10.1016/s0957-4166(01)00199-9

  日期：2001.5

  Starting from (S)-1.1 ' -binaphthol, a series of ten novel enantiopure 1.1 ' -binaphthylazepine-based aminoalcohols and diamines 1a-1j were efficiently prepared and fully characterized. These derivatives, having either only an atropisomeric bridged-binaphthyl backbone or an additional stereogenic carbon center, can be interesting ligands for asymmetric catalysis. (C) 2001 Elsevier Science Ltd. All rights reserved.