3-amino-2-methyl-3-phenyl-propionic acid | 24180-12-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-2-methyl-3-phenyl-propionic acid
• 英文别名: 3-Amino-2-methyl-3-phenyl-propionsaeure；β-Amino-β-phenyl-isobuttersaeure；3-Amino-2-methyl-3-phenylpropanoic acid
• CAS: 24180-12-9
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: OWJWPDFSPYKDDA-UHFFFAOYSA-N

物化性质

• 沸点：
  312.8±30.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-amino-2-methyl-3-phenyl-propionic acid 在 水 作用下， 生成 5-methyl-6-phenyl-dihydro-pyrimidine-2,4-dione
  参考文献：
  名称：

  Posner, Justus Liebigs Annalen der Chemie, 1912, vol. 389, p. 36,111

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 羟胺 作用下， 生成 3-amino-2-methyl-3-phenyl-propionic acid
  参考文献：
  名称：

  Posner, Justus Liebigs Annalen der Chemie, 1912, vol. 389, p. 36,111

  摘要：

  DOI：

文献信息

• BETA-AMINO ACIDS AND METHODS AND INTERMEDIATES FOR MAKING SAME
  申请人：Sibi Mukund P.

  公开号：US20110218342A1

  公开（公告）日：2011-09-08

  Disclosed are β-amino acids that are unsubstituted in the β position; that are substituted in the β position with an aryl group; that are substituted in the α position with an aryl group; that bear two substituents in the α position; and/or that are substituted in the α and β positions with groups which, together with the carbon atoms at the α and β positions, form a ring. Also disclosed are methods for making the above-mentioned β-amino acids and other β-amino acids which involve providing an α,β-unsaturated imide; converting the α,β-unsaturated imide to a 2-substituted-isoxazolidin-5-one; and converting the 2-substituted-isoxazolidin-5-one to a β-amino acid.

  披露了未在β位取代的β-氨基酸；在β位用芳基取代的β-氨基酸；在α位用芳基取代的β-氨基酸；在α位带有两个取代基的β-氨基酸；和/或在α和β位用与α和β位的碳原子一起形成环的基团取代的β-氨基酸。还披露了制备上述β-氨基酸和其他β-氨基酸的方法，包括提供α，β-不饱和亚胺；将α，β-不饱和亚胺转化为2-取代异噁唑啉-5-酮；将2-取代异噁唑啉-5-酮转化为β-氨基酸。
• Mild and efficient deprotection of the amine protecting p-methoxyphenyl (PMP) group
  作者：Jorge M.M. Verkade、Lieke J.C. van Hemert、Peter J.L.M. Quaedflieg、Paul L. Alsters、Floris L. van Delft、Floris P.J.T. Rutjes

  DOI：10.1016/j.tetlet.2006.09.044

  日期：2006.11

  Mild and efficient procedures for deprotection of the amine nitrogen protecting p-methoxyphenyl (PMP) group are described. Periodic acid and trichloroisocyanuric acid (TCCA) were found to be particularly effective in realizing amine liberation using 1 and 0.5 equiv of the oxidant, respectively. Extension of the periodic acid-mediated conditions to simultaneous alcohol oxidation by combination with

  描述了用于保护胺氮保护的对-甲氧基苯基（PMP）基团的脱保护的温和而有效的程序。发现高碘酸和三氯异氰尿酸（TCCA）在分别使用1和0.5当量的氧化剂实现胺释放方面特别有效。通过与催化量的重铬酸钠组合，将高碘酸介导的条件扩展至同时进行醇氧化，可在一锅法中将PMP保护的曼尼希产物顺利转化为相应的β-氨基酸。
• Diastereoselective Hydrogenation of Methyl 2-[α-(Methoxycarbonylamino)benzyl]acrylate Catalyzed by Ru(II) or Rh(I) Complexes
  作者：Keiji Yamamoto、Masatoshi Takagi、Jiro Tsuji

  DOI：10.1246/bcsj.61.319

  日期：1988.1

  The title compound was prepared and hydrogenated by using a Ru(II)- or Rh(I)-phosphine catalyst precursor with excellent anti-selectivity, the results indicating that a ligating group, NHCO2Me, may direct the addition of hydrogen to an olefinic diastereoface proximate to this group which binds the catalyst.

  使用具有优异抗选择性的 Ru(II)- 或 Rh(I)-膦催化剂前体制备并氢化标题化合物，结果表明连接基团 NHCO2Me 可将氢加成到烯烃非对映体上靠近结合催化剂的这个基团。
• Integrin antagonists useful as anticancer agents
  申请人：Bloxham Jason

  公开号：US20060116383A1

  公开（公告）日：2006-06-01

  The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X 2 , X 4 , X 5 and X 1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.

  该发明涉及公式1的化合物，以及其药用可接受的盐和溶剂化合物，其中A、X2、X4、X5和X1的定义如本文所述。该发明还涉及通过给予公式1的化合物来治疗哺乳动物体内的异常细胞增长的方法，以及用于治疗这类疾病的含有公式1化合物的药物组合物。
• Derivatives of beta-aminopropionic acid with a fungicidal activity
  申请人：ISAGRO RICERCA S.r.l.

  公开号：EP0718280A2

  公开（公告）日：1996-06-26

  Compounds based on derivatives of β-aminopropionic acid having the general formula (I): The compounds having general formula (I) have a high antifungal activity.

  基于通式(I)的β-氨基丙酸衍生物的化合物： 通式（I）的化合物具有很高的抗真菌活性。