aniline-2,5-disulfonic acid, disodium salt

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: aniline-2,5-disulfonic acid, disodium salt
• 英文别名: sodium aniline disulphonate；Sodium;2-aminobenzene-1,4-disulfonate
• 化学式: C₆H₅NO₆S₂*2Na
• 分子量: 297.22
• InChiKey: SYFQTIIOWUIZGU-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -3.92
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  157
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-硝基异酞酰氯 、 aniline-2,5-disulfonic acid, disodium salt 在 sodium carbonate 作用下， 以 甲苯 为溶剂， 以58.7%的产率得到
  参考文献：
  名称：

  Structure–activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist

  摘要：

  NF449 [4,4',4"-4'''-(carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid-octasodiumsalt)] was recently described to inhibit recombinant rP2X(1) receptors (Naunyn Schmiedeberg's Arch. Pharmacol. 364 (2001) 285). The purpose of this study was to examine structure-activity-relationships at P2 receptors of a series of NF449 analogues. Thus, compounds containing various arylaminemono-, di-, or trisulfonic acids and a replacement of the central urea bridge were synthesized. NF449 displayed a pIC(50) at P2X(I) receptors (rat vas deferens) of 6.31 +/- 0.04 being at least 19-fold more potent at P2X(1) than at P2X(3), P2Y(1), P2Y(2), or P2Y(11). Any deletion or chance of position of sulfonic acid groups or replacing the central urea bond by the bisamide of terephthalic acid reduced the potency at P2X(1) by at least 90%. All compounds were very weak antagonists at P2Y(2) or P2Y(11) receptors (pIC(50) < 4.5). In conclusion, NF449 remains the most potent and selective P2X(1) antagonist known. Potential lead compounds among the suramin class for P2X(3) (16d) and P2Y(1) (16a) receptors were identified. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.01.007

文献信息

• Synthesis of novel green reactive dyes and relationship between their structures and printing properties
  作者：Hongjuan Zhang、Jiping Wang、Kongliang Xie、Liujun Pei、Aiqin Hou

  DOI：10.1016/j.dyepig.2019.108079

  日期：2020.3

  yellow azo and blue anthraquinone chromophores, five green reactive dyes with different number of sulfonate groups were synthesized. The relationship between their structures and printing properties was investigated in terms of color yield and fastness properties. The results showed the reactive dye with fewer number of sulfonate groups was more sensitive to alkaline. The color yields of dyes with

  基于黄色偶氮和蓝色蒽醌发色团的分子内配色，合成了五种具有不同磺酸根基团的绿色活性染料。研究了它们的结构和印刷性能之间的关系，涉及颜色产量和牢度性能。结果表明，具有较少磺酸盐基团的活性染料对碱性更敏感。以萘衍生物为重氮组分的具有多个磺酸根基团的染料，其色产率明显受尿素浓度的影响，但其增色性能较好。此外，随着磺酸盐基团的增加，颜色产率（整色值）和流平性显着增加。所有合成的绿色活性染料均具有优异的牢度和更好的印刷再现性。
• US2014/339462
  申请人：——

  公开号：——

  公开（公告）日：——