5-p-Methylbenzyliden-2-imino-4-thiazolidinon | 36946-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-p-Methylbenzyliden-2-imino-4-thiazolidinon
• 英文别名: 2-Imino-5-[(4-methylphenyl)methylidene]-1,3-thiazolidin-4-one；2-imino-5-[(4-methylphenyl)methylidene]-1,3-thiazolidin-4-one
• CAS: 36946-76-6
• 化学式: C₁₁H₁₀N₂OS
• mdl: MFCD00453625
• 分子量: 218.279
• InChiKey: VMIJJMVEQOFALP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲基苯甲醛 、 假硫代乙内酰脲 在 sodium acetate 、 溶剂黄146 作用下， 反应 0.17h， 以78%的产率得到5-p-Methylbenzyliden-2-imino-4-thiazolidinon
  参考文献：
  名称：

  A Facile Synthesis of 5-Arylidene-2-imino-4-thiazolidinones Under Microwave Irradiation

  摘要：

  A series of 5-arylidene-2-imino-4-thiazolidinone derivatives were synthesized by the cross-aldol condensation of aromatic aldehydes with 2-imino-4-thiazolidinone in sodium acetate/acetic acid under microwave irradiation. The reactions were completed in 10min with 63-91% yields, were environmental benign, and had easy workup.

  DOI：

  10.1080/00397910802323072

文献信息

• A Facile Synthesis of 5-Arylidene-2-imino-4-thiazolidinones Under Microwave Irradiation
  作者：Jian-Feng Zhou、Xiao-Jun Sun、Feng-Xia Zhu、Yan-Lun Li、Gui-Xia Gong

  DOI：10.1080/00397910802323072

  日期：2008.11.3

  A series of 5-arylidene-2-imino-4-thiazolidinone derivatives were synthesized by the cross-aldol condensation of aromatic aldehydes with 2-imino-4-thiazolidinone in sodium acetate/acetic acid under microwave irradiation. The reactions were completed in 10min with 63-91% yields, were environmental benign, and had easy workup.