DL-9-Methyloctadecansaeure | 86073-38-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: DL-9-Methyloctadecansaeure
• 英文别名: 9-Methyloctadecanoic acid
• CAS: 86073-38-3
• 化学式: C₁₉H₃₈O₂
• 分子量: 298.51
• InChiKey: FUDUTAVRRCALAT-UHFFFAOYSA-N

物化性质

• 熔点：
  40°C
• 沸点：
  380.63°C (estimate)
• 密度：
  0.8865 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  DL-9-Methyloctadecansaeure 在 草酰氯 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 Octadecanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-9-methyl-, (+-)-
  参考文献：
  名称：

  香草。1.具有抗伤害感受和抗炎活性的辣椒素类似物。

  摘要：

  作为建立香草醛的结构活性关系的程序的一部分，辛辣成分辣椒素的类似物，母体结构的烷基链部分（以及衍生自高香草酸的相关化合物）发生了变化。在抗伤害感受和抗炎试验（大鼠和小鼠热板以及巴豆油刺激的小鼠耳朵）中，具有广泛变化的烷基链结构的化合物具有活性。短链化合物在上述测定中通过全身给药具有活性，但它们保留了辣椒素的高刺激性和急性毒性特征。相比之下，长链顺式不饱和物NE-19550（香草基油酰胺）和NE-28345（油基单香草酰胺）具有口服活性，刺激性较低，并且比辣椒素的急性毒性小。

  DOI：

  10.1021/jm00070a002
• 作为产物：
  描述：

  壬酸 在 甲醇 、 sodium 作用下， 生成 DL-9-Methyloctadecansaeure
  参考文献：
  名称：

  Hallgren, Arkiv foer Kemi, 1956, vol. 9, p. 389,393

  摘要：

  DOI：

文献信息

• Method of modifying the lipid structure function and expression of cell membranes and pharmaceutical compositions for use therein
  申请人：Habib, Nagy Adly

  公开号：EP0238198A2

  公开（公告）日：1987-09-23

  The invention is concerned with the use of certain fatty acids and inhibitors of an enzyme in effecting modifications to the lipid structure of cell membranes and in modifying the degree of expression of cell receptors and antigen determinants. The invention also relates to the formulation of pharmaceutical compositions and medicaments and to such products per se; to the treatment of a variety of clinical and veterinary disorders associated with a lowering of the saturation index of cell membranes, including malignancies, viral disorders and AIDS; and to the use of the active materials of the invention in the relief of pain and in bioengineering processes. The active principals in the present invention are saturated fatty acids having from 12 to 28 carbon atoms in the alkyl chain, e.g. stearic acid, or pharmaceutically acceptable derivatives thereof; and inhibitors of the enzyme A-9 desaturase, e.g. sterculic acid and malvalic acid or pharmacologically active derivatives or analogues thereof. Interferon is also used in modifying the expression of cell receptors and antigenic determinants.

  本发明涉及使用特定脂肪酸和酶抑制剂来改变细胞膜的脂质结构和修改细胞受体和抗原决定物的表达程度。本发明还涉及制药组合物和药物的配方以及这些产品本身；用于治疗与细胞膜饱和度降低相关的各种临床和兽医疾病，包括恶性肿瘤、病毒性疾病和艾滋病；以及在缓解疼痛和生物工程过程中使用本发明的活性物质。本发明中的活性成分是具有12至28个碳原子的烷基链的饱和脂肪酸，例如硬脂酸，或其药学上可接受的衍生物；以及A-9去饱和酶的抑制剂，例如苦蓬酸和马鸭酸或其药理活性的衍生物或类似物。干扰素也被用于修改细胞受体和抗原决定物的表达。
• Method of making an organic metal salt or complex
  申请人：NATIONAL RESEARCH LABORATORIES

  公开号：EP0008174A1

  公开（公告）日：1980-02-20

  method of making an organic metal salt or complex is disclosed by reacting a heavy metal hydroxide with an organic Lewis acid or salt thereof in the presence of a form of CO2. The reaction may be controlled by the addition of a buffering agent. The method produces organic metal complexes or salts in a pure second salt-free state either in a solution or solid state.

  本发明公开了一种制造有机金属盐或络合物的方法，该方法是在一种二氧化碳形式的存在下，使重金属氢氧化物与有机路易斯酸或其盐发生反应。可通过添加缓冲剂来控制反应。该方法可以在溶液或固体状态下生产出纯的第二种无盐状态的有机金属络合物或盐。
• Two-component urethane coating system
  申请人：The Lubrizol Corporation

  公开号：EP0094196A2

  公开（公告）日：1983-11-16

  The present invention contemplates the provision of two-component urethane coating compositions comprising a first component comprising an organic polyfunctional isocyanate, and a second component comprising an acidic ester of a phosphoric acid, the alcohol portions of said acidic acid being selected from the group consisting of hydrocarbyloxy and hydroxysubstituted hydrocarbyloxy compounds, such compositions providing enhanced corrosion resistance properties as well as improved flame retardency and metal adhesion characteristics over the two-component urethane systems of the prior art. An essential ingredient in the compositions of the invention is a non-Newtonian colloidal disperse system which can be provided with either the first component and/or the second component parts of the compositions of the invention. The non-Newtonian colloidal disperse systems provided in accordance with the present invention comprise (1) solid metal-containing colloidal particles predispersed in (2) a disperse medium of at least one inert organic liquid and (3) as an essential third component at least one member selected from the class consisting of organic compounds which are substantially soluble in said disperse medium, the molecules of said organic compound being characterized by polar substituents and hydrophobic portions. The invention also relates to a method of coating a substrate comprising mixing the foregoing components and depositing the resulting composition on said substrate.

  本发明考虑提供双组分聚氨酯涂料组合物，其第一组分包括有机多官能团异氰酸酯，第二组分包括磷酸的酸性酯，所述酸性酸的醇部分选自烃比氧基和羟基取代烃比氧基化合物组成的组，与现有技术的双组分聚氨酯体系相比，这种组合物具有更强的耐腐蚀性能，以及更好的阻燃性和金属粘附性。本发明组合物中的一种重要成分是非牛顿胶体分散系统，它可以与本发明组合物的第一组分和/或第二组分一起提供。根据本发明提供的非牛顿胶体分散体系包括：(1) 预先分散在 (2) 至少一种惰性有机液体的分散介质中的含金属固体胶体颗粒；(3) 作为重要的第三组分，至少一种选自有机化合物类别的成员，这些有机化合物基本上可溶于所述分散介质，所述有机化合物的分子具有极性取代基和疏水部分。本发明还涉及一种涂覆基质的方法，包括混合上述组分并将所得组合物沉积在所述基质上。
• One-component moisture curable urethane coating system
  申请人：The Lubrizol Corporation

  公开号：EP0094261A2

  公开（公告）日：1983-11-16

  A composition comprising: (A) a non-Newtonian colloidal disperse system comprising (1) solid metal-containing colloidal particles predispersed in (2) a disperse medium of at least one inert organic liquid and (3) as an essential third component at least one member selected from the class consisting of organic compounds which are substantially soluble in said disperse medium, the molecules of said organic compound being characterized by polar substituents and hydrophobic portions; and (B) an isocyanate-terminated prepolymer.

  一种组合物，包括：(A)非牛顿胶体分散体系，该体系包含(1)预先分散在(2)由至少一种惰性有机液体组成的分散介质中的含金属固体胶体颗粒，以及(3)作为基本第三组分的至少一种选自有机化合物类别的成员，这些有机化合物基本上可溶于所述分散介质，所述有机化合物的分子具有极性取代基和疏水部分；以及(B)异氰酸酯封端预聚物。
• Method for reducing friction between railroad wheel and railway track using metal overbased colloidal disperse systems
  申请人：The Lubrizol Corporation

  公开号：EP0394033A1

  公开（公告）日：1990-10-24

  A method for reducing friction between railroad wheel and railway track is disclosed comprising applying to the railway track a composition comprising an overbased non-Newtonian colloidal disperse system comprising: (1) solid metal-containing colloidal particles pre-­dispersed in (2) a disperse medium of at least one inert organic liquid and (3) at least one member selected from the class consisting of organic com­pounds which are substantially soluble in the disperse medium, the molecules of said organic compound being characterized by polar substituents and hydrophobic portions.

  本发明公开了一种减少铁轮与铁轨之间摩擦力的方法，该方法包括在铁轨上使用一种组合物，该组合物包含一种过基非牛顿胶体分散系统，该系统包括：(1) 预先分散在至少一种惰性有机液体的分散介质中的含金属固体胶体颗粒；(2) 至少一种惰性有机液体的分散介质；(3) 至少一种选自有机化合物类别的成员，这些有机化合物基本上可溶于分散介质，所述有机化合物的分子具有极性取代基和疏水部分。