8-C-(2"-O-β-D-apiofuranosyl)-β-D-glucopyranosyl apigenin | 1275615-11-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 8-C-(2"-O-β-D-apiofuranosyl)-β-D-glucopyranosyl apigenin
• 英文别名: ficuflavoside；8-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• CAS: 1275615-11-6
• 化学式: C₂₆H₂₈O₁₄
• 分子量: 564.5
• InChiKey: SENCXQGUCJRSOW-LBFLXUOUSA-N

物化性质

• 沸点：
  923.2±65.0 °C(Predicted)
• 密度：
  1.79±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  236
• 氢给体数：
  9
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  8-C-(2"-O-β-D-apiofuranosyl)-β-D-glucopyranosyl apigenin 在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 3.0h， 生成 D-apiose
  参考文献：
  名称：

  Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa

  摘要：

  By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5 mu M Trolox equivalents at the concentration of 2.0 mu M. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.025

文献信息

• Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa
  作者：Phan Van Kiem、Nguyen Xuan Cuong、Nguyen Xuan Nhiem、Vu Kim Thu、Ninh Khac Ban、Chau Van Minh、Bui Huu Tai、Truong Nam Hai、Sang Hyun Lee、Hae Dong Jang、Young Ho Kim

  DOI：10.1016/j.bmcl.2010.12.025

  日期：2011.1

  By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5 mu M Trolox equivalents at the concentration of 2.0 mu M. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4 mu M. (C) 2010 Elsevier Ltd. All rights reserved.