2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethanol | 1032648-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethanol
• 英文别名: 2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(1-pyridin-3-ylindazol-5-yl)ethanol
• CAS: 1032648-37-5
• 化学式: C₂₂H₁₅F₃N₄O
• 分子量: 408.383
• InChiKey: MZHOYJJFGDWALS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-碘乙酰胺 、 2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethanol 在 氢氧化钾 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以39%的产率得到2-{3-[2,2,2-trifluoro-1-hydroxy-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethyl]indol-1-yl}acetamide
  参考文献：
  名称：

  WO2008/70507

  摘要：

  公开号：
• 作为产物：
  描述：

  5-bromo-1-pyridin-3-yl-1H-indazole 、 2,2,2-trifluoro-1-(1H-indol-3-yl)ethanone sodium salt 在 正丁基锂 、 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.02h， 以10%的产率得到2,2,2-trifluoro-1-(1H-indol-3-yl)-1-(1-pyridin-3-yl-1H-indazol-5-yl)ethanol
  参考文献：
  名称：

  WO2008/70507

  摘要：

  公开号：

文献信息

• Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof
  申请人：Kuzmich Daniel

  公开号：US20100197678A1

  公开（公告）日：2010-08-05

  Compounds of Formula (IA) wherein R 1 , R 2 , R 3 , A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  该文提到的化合物的分子式为（IA），其中R1，R2，R3，A，B，C，D，E，G，X，Y和Z的定义如本文所述，或其自身的异构体，前药，溶剂化物或盐；包含这些化合物的药物组合物，以及使用这些化合物调节糖皮质激素受体功能的方法，以及治疗由糖皮质激素受体功能介导或以炎症，过敏或增生过程为特征的疾病状态或情况的方法。
• Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
  申请人：Kuzmich Daniel

  公开号：US08658637B2

  公开（公告）日：2014-02-25

  Compounds of Formula (IA) wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

  该配方的化合物（IA），其中R1，R2，R3，A，B，C，D，E，G，X，Y和Z如此定义，或其互变异构体，前药，溶剂或盐; 含有这些化合物的制药组合物，并使用这些化合物调节糖皮质激素受体功能的方法，以及治疗由糖皮质激素受体功能介导或以炎症，过敏或增生过程为特征的疾病状态或病情的方法。
• ABSORBABLE PROTECTIVE COATINGS FOR WOUND WITH THE USE OF CELLULOSE SPONGE AND PROCESS FOR PRODUCING THE SAME
  申请人：Hogy Medical Co., Ltd.

  公开号：EP1269951A1

  公开（公告）日：2003-01-02

  The object is to provide an absorptive wound covering protecting material and a method for preparing the same which is quite excellent in an absorptiveness and a liquid-holding property, and is superior in shape-maintaining ability and strength, and wherein a reinforcement can be used and workability is improved, as well as a hemostatic wound healing effect can be enhanced, compared to an absorptive wound covering protecting material comprising a thinly solidified cellulose sponge. A method for preparing an absorptive wound covering protecting material is characterized by solidifying a sponge raw solution containing no reinforcement that is obtained by mixing viscose and crystalline mirabilite as main raw materials, or a sponge raw solution obtained by mixing viscose containing a reinforcement comprising natural fibers having a length of at least 5 mm to 40 mm, and crystalline mirabilite as main raw materials, by performing a heat treatment on the sponge raw solution, and then forming the solidified cellulose sponge in a thickness somewhat greater than a desired thickness, and then forming the cellulose sponge in a sheet form having a desired thickness by compressing the cellulose sponge, and, if required, carboxymethylating hydroxyl groups in a glucose unit constituting a cellulose sponge so that a degree of substitution of the hydroxyl groups is from 0.5 to less than 1.0, and then, forming an incision the cellulose sponge.

  本发明的目的是提供一种吸收性伤口覆盖保护材料及其制备方法，与由薄固化纤维素海绵组成的吸收性伤口覆盖保护材料相比，该材料具有相当优异的吸收性和持液性，并且在保持形状的能力和强度方面也更胜一筹，而且可以使用增强剂，提高了可加工性，并增强了止血伤口愈合效果。 一种用于制备吸收性伤口覆盖保护材料的方法，其特征在于将不含增强剂的海绵原液凝固，该原液是由粘胶和结晶海泡石作为主要原料混合而成，或者是由粘胶和结晶海泡石作为主要原料混合而成，该粘胶含有增强剂，增强剂包括长度至少为 5 毫米至 40 毫米的天然纤维、对海绵原液进行热处理，然后使凝固的海绵纤维素的厚度略大于所需的厚度，然后通过压缩海绵纤维素使其形成具有所需厚度的片状，如有必要，对构成海绵纤维素的葡萄糖单元中的羟基进行羧甲基化，使羟基的取代度为 0.5 至小于 1.0，然后在纤维素海绵上形成切口。
• SHRINK FILM, PROCESS FOR PRODUCING THE SAME, PRINTING INK, PRINT PRODUCED THEREWITH AND PROCESS FOR PRODUCING PRINT
  申请人：TOYO INK MFG. CO., LTD.

  公开号：EP1514680A1

  公开（公告）日：2005-03-16

  A coating material of an electron beam curable type is printed or coated onto a substrate of a heat shrinkable plastic film. Then, the coating material is cured by electron beam irradiation to form a coating layer. As a consequence, a shrinkable film including the substrate and the coating layer disposed thereon is obtained.

  在热收缩塑料薄膜基材上印刷或涂布电子束固化型涂层材料。然后，通过电子束照射使涂层材料固化，形成涂层。这样就得到了包括基底和涂覆层在内的热收缩薄膜。
• Dissolvable rubber
  申请人：Terves Inc.

  公开号：US10308807B2

  公开（公告）日：2019-06-04

  A degradable elastomeric material that is formed from a composite blend of elastomeric particles in a continuous degradable binder. The degradable binder is generally a water-soluble binder which has a temperature dependent solubility in water and brine systems. Such degradable elastomers are particularly useful in the fabrication of degradable oil tools, among other applications.

  一种可降解弹性材料，由弹性颗粒与连续可降解粘合剂复合而成。可降解粘合剂通常是一种水溶性粘合剂，在水和盐水系统中的溶解度与温度有关。这种可降解弹性体在制造可降解石油工具等方面特别有用。