3-(furan-2-yl)-5-phenyl-1H-1,2,4-triazole | 114953-90-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(furan-2-yl)-5-phenyl-1H-1,2,4-triazole
• 英文别名: 3-(2-Furyl)-5-phenyl-4H-1,2,4-triazole；5-(furan-2-yl)-3-phenyl-1H-1,2,4-triazole
• CAS: 114953-90-1
• 化学式: C₁₂H₉N₃O
• 分子量: 211.223
• InChiKey: POZTVAYJBZIQQT-UHFFFAOYSA-N

物化性质

• 熔点：
  190-193 °C
• 沸点：
  426.4±37.0 °C(Predicted)
• 密度：
  1.260±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-呋喃甲酰肼 、 苄脒盐酸盐 在 potassium carbonate 作用下， 以 水 为溶剂， 反应 43.0h， 以84%的产率得到3-(furan-2-yl)-5-phenyl-1H-1,2,4-triazole
  参考文献：
  名称：

  3,5-二取代的1,2,4-三唑的绿色水合成及抗菌性能评估

  摘要：

  提出了一种生态友好且简单的方法，用于通过盐酸苄be与各种芳基酰肼的优化反应合成3,5-二取代的1,2,4-三唑。H 2 O和K 2 CO 3分别作为绿色和可用溶剂和碱。只需一步就可以生成高至高收率的产品，并且在简单的后处理后即可获得足够的纯度。设计的方法适用于其他有机合成，尤其是水溶性差的反应物（例如肼或酰肼）的合成。评价了所有制备的衍生物对10种致病菌菌株（包括革兰氏阳性和革兰氏阴性）以及2种霉菌和1种酵母菌株的抑制活性。制备的衍生物显示出良好的抗菌活性。在3位上含有2-羟基萘-3-基和5-氯噻吩-2-基取代基的1,2,4-三唑分别显示出最佳的抗真菌和抗菌性能。

  DOI：

  10.1007/s10593-020-02684-7

文献信息

• Resin composition
  申请人：KONICA MINOLTA, INC.

  公开号：US10012777B2

  公开（公告）日：2018-07-03

  The present invention provides a resin composition capable of forming a film exhibiting a small humidity-dependent variation in optical values; a triazole compound to be incorporated into the resin composition; an optical film and an optical lens, each of which is prepared from the resin composition and exhibits a small humidity-dependent variation in optical values; and a polarizing plate, a circularly polarizing plate, and an image display device, each of which includes the optical film and exhibits excellent moisture resistance. The resin composition of the present invention contains a resin and a compound having a 5-membered or 6-membered aromatic hydrocarbon or heterocyclic ring, wherein the resin is a hygroscopic resin, the compound has at least three specific aromatic rings having a specific NICS value, and the specific aromatic rings are bonded to one another via a single bond or one or two atoms.

  本发明提供了一种能够形成薄膜的树脂组合物，其光学值随湿度的变化很小；一种三唑化合物，可掺入该树脂组合物中；一种光学薄膜和一种光学透镜，它们分别由该树脂组合物制备而成，其光学值随湿度的变化很小；以及一种偏光板、一种圆偏光板和一种图像显示装置，它们分别包括该光学薄膜，并具有优异的防潮性能。本发明的树脂组合物包含一种树脂和一种具有 5 元或 6 元芳香烃环或杂环的化合物，其中树脂是一种吸湿性树脂，化合物具有至少三个具有特定 NICS 值的特定芳香环，特定芳香环通过单键或一个或两个原子相互结合。
• A convenient synthesis of 3,5-disubstituted-1,2,4-triazoles
  作者：J.E. Francis、L.A. Gorczyca、G.C. Mazzenga、H. Meckler

  DOI：10.1016/s0040-4039(00)95610-7

  日期：——
• FRANCIS, J. E.;GORCZYCA, L. A.;MAZZENGA, G. C.;MECKLER, H., TETRAHEDRON LETT., 28,(1987) N 43, 5133-5136
  作者：FRANCIS, J. E.、GORCZYCA, L. A.、MAZZENGA, G. C.、MECKLER, H.

  DOI：——

  日期：——
• RESIN COMPOSITION, TRIAZOLE COMPOUND, OPTICAL FILM, POLARIZING PLATE, OPTICAL LENS, CIRCULARLY POLARIZING PLATE AND IMAGE DISPLAY DEVICE
  申请人：KONICA MINOLTA, INC.

  公开号：US20150338563A1

  公开（公告）日：2015-11-26

  The present invention provides a resin composition capable of forming a film exhibiting a small humidity-dependent variation in optical values; a triazole compound to be incorporated into the resin composition; an optical film and an optical lens, each of which is prepared from the resin composition and exhibits a small humidity-dependent variation in optical values; and a polarizing plate, a circularly polarizing plate, and an image display device, each of which includes the optical film and exhibits excellent moisture resistance. The resin composition of the present invention contains a resin and a compound having a 5-membered or 6-membered aromatic hydrocarbon or heterocyclic ring, wherein the resin is a hygroscopic resin, the compound has at least three specific aromatic rings having a specific NICS value, and the specific aromatic rings are bonded to one another via a single bond or one or two atoms.
• TRIAZOLE COMPOUND
  申请人：KONICA MINOLTA, INC.

  公开号：US20180203175A1

  公开（公告）日：2018-07-19

  A triazole compound having a structure represented by the following Formula (1.2): wherein Z represents a structure represented by the following Formula (1.2a), q is 2 or 3, and at least two structures Z bonded to the benzene ring of Formula (1.2) and are located in the ortho- or meta-position relative to each other: wherein R 10 represents a hydrogen atom, an alkyl group, or an alkoxy group, p represents an integer of 1 to 5, and * represents a position at which the structure is bonded to the benzene ring.