2,2-Dimethyl-buten-(3)-saeure-(1)-amid | 7472-48-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2-Dimethyl-buten-(3)-saeure-(1)-amid
• 英文别名: Dimethyl-vinyl-acetamid；2,2-dimethyl-but-3-enoic acid amide；2,2-Dimethyl-but-3-ensaeure-amid；2,2-Dimethyl-but-3-enamid；β-Methyl-γ-butylen-β-carbonsaeureamid；Dimethylvinylessigsaeureamid；2,2-Dimethylbut-3-enamide
• CAS: 7472-48-2
• 化学式: C₆H₁₁NO
• mdl: MFCD19203821
• 分子量: 113.159
• InChiKey: KDAWWBHNSCBKSW-UHFFFAOYSA-N

物化性质

• 熔点：
  97 °C
• 沸点：
  204.3±19.0 °C(Predicted)
• 密度：
  0.916±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-buten-(3)-saeure-(1)-amid 在 alkaline aqueous sodium hypochlorite 作用下， 生成 2-甲基丁-3-烯-2-胺
  参考文献：
  名称：

  Allylic Rearrangements. XL. The Reaction of Allylic Diazonium Ions in Acetic Acid¹

  摘要：

  DOI：

  10.1021/ja01553a040
• 作为产物：
  描述：

  2,2-二甲基-3-丁烯酸 在 氨 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 2,2-Dimethyl-buten-(3)-saeure-(1)-amid
  参考文献：
  名称：

  Total Synthesis of the Potent HIF-1 Inhibitory Antitumor Natural Product, (8R)-Mycothiazole, via Baldwin–Lee CsF/CuI sp³–sp²-Stille Cross-Coupling. Confirmation of the Crews Reassignment

  摘要：

  A convenient asymmetric total synthesis of the potent HIF-1 inhibitory antitumor natural product, (-)- or (+)-(8R)-mycothiazole (1), is described. Not only does our synthesis confirm the 2006 structural reassignment made by Crews (Crews, P., et al. J. Nat. Prod. 2006, 69, 145), it revises the [a]p data previously reported for this molecule in MeOH from -13.7 degrees to +42.3 degrees. The newly developed route to (8R)-1 sets the C(8)-OH stereocenter via Sharpless AE/2,3-epoxy alcohol reductive ring opening and utilizes two Baldwin-Lee CsF/cat. CuI Stille cross-coupling reactions with vinylstannanes 8 and 3 to efficiently elaborate the C(1) C(4) and C(14) C(18) sectors.

  DOI：

  10.1021/acs.orglett.5b01966

文献信息

• [EN] COMPOSITIONS AND METHODS OF MANUFACTURING AMPHIPHILIC BLOCK COPOLYMERS THAT FORM NANOPARTICLES IN SITU<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE FABRICATION DE COPOLYMÈRES SÉQUENCÉS AMPHIPHILES QUI FORMENT DES NANOPARTICULES IN SITU
  申请人：AVIDEA TECH INC

  公开号：WO2022066635A1

  公开（公告）日：2022-03-31

  An amphiphilic block copolymer having any one of the formulas D-S-H, S(D)-H, S-H(D), D-S-H-S, D-S-H-S-D, S(D)-H-S, S(D)-H-S(D) or S-H(D)-S is disclosed. S is a hydrophilic block; H is a hydrophobic block; D is a drug molecule; ( ) denotes that the group is bonded directly or indirectly as a side chain or as part of a side chain group to the adjacent group; and the hyphen, "-" (or sometimes "–"), denotes that each of the adjacent S, H or D are linked either directly to one another or indirectly to one another via a linker, additionally wherein the hydrophilic block comprises a first hydrophilic monomer and the hydrophobic block comprises a first hydrophobic monomer and a second hydrophobic monomer.

  本发明公开了一种具有以下任一公式之一的两亲性嵌段共聚物：D-S-H，S（D）-H，S-H（D），D-S-H-S，D-S-H-S-D，S（D）-H-S，S（D）-H-S（D）或S-H（D）-S。其中，S是亲水性块；H是疏水性块；D是药物分子；（）表示该基团直接或间接地作为侧链或侧链基团之一与相邻基团连接；连字符“-”（有时为“–”）表示相邻的S、H或D之间通过连接基团直接或间接连接在一起。此外，亲水性块包括第一亲水性单体，疏水性块包括第一疏水性单体和第二疏水性单体。
• Cyclic Amine Compound and Use Thereof for the Prophylaxis or Treatment of Hypertension
  申请人：Kuroita Takanobu

  公开号：US20100121048A1

  公开（公告）日：2010-05-13

  The present invention relates to a compound represented by the formula: (I) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent(s), a C 1-10 alkyl group optionally having substituent(s), a C 2-10 alkenyl group optionally having substituent(s), or a C 2-10 alkynyl group optionally having substituent(s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent(s); m and n are each independently 1 or 2; and ring B optionally further has substituent(s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

  本发明涉及一种由式(I)表示的化合物：其中，环A是一种5或6成员的芳香杂环，可选地具有取代基；U、V和W分别独立地为C或N，但当U、V和W中的任何一个为N时，其他的应为C；Ra和Rb分别独立地为一个环状基团，可选地具有取代基；一个C1-10烷基，可选地具有取代基；一个C2-10烯基，可选地具有取代基；或一个C2-10炔基，可选地具有取代基；X是一条键或具有1到6个原子的主链间隔；Y是具有1到6个原子的主链间隔；Rc是一个含有杂原子作为构成原子的碳氢基团，可选地具有取代基；m和n分别独立地为1或2；环B可选地具有取代基，或其盐。本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压、高血压引起的各种器官损伤等的药物。
• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
  申请人：Shionogi&Co., Ltd.

  公开号：EP2163543A1

  公开（公告）日：2010-03-17

  Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is -OR5, -SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.

  本发明公开了一种可用作 11β- 羟基类固醇脱氢酶 1 型抑制剂的化合物。 一种由式表示的化合物： 、其药学上可接受的盐或其溶液、 其中环 A 是由式表示的基团： 环 B 是任选取代的杂芳基（但不包括任选取代的异噁唑）或任选取代的杂环、 R1 是氢或任选取代的烷基、 R2 是-OR5、-SR5、卤素、卤代烷基或类似物、 R3 是任选取代的烷基或类似物、 R4 是任选取代的烷基或类似物、 R5 是任选取代的烷基或类似物、 R6 是氢或类似物、 R7 和 R8 各自独立地为氢或类似物、 R10 和 R11 各自独立地为氢或类似物、 R12 是任选取代的烷基或类似物、 m 和 p 各自独立地为 1 至 3 的整数。
• Courtot, Bulletin de la Societe Chimique de France, 1906, vol. <3>35, p. 121
  作者：Courtot

  DOI：——

  日期：——
• SALZE VON WIRKSTOFFEN MIT POLYMEREN GEGENIONEN
  申请人：BASF SE

  公开号：EP2229151B1

  公开（公告）日：2012-08-08