3-acetoxy-2,2-dimethyl-propionitrile | 41296-71-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-acetoxy-2,2-dimethyl-propionitrile
• 英文别名: Acetoxy-pivalinsaeure-nitril；(2-Cyano-2-methylpropyl) acetate；(2-cyano-2-methylpropyl) acetate
• CAS: 41296-71-3
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: JQSWZPFIQAZQFB-UHFFFAOYSA-N

物化性质

• 沸点：
  220.4±23.0 °C(Predicted)
• 密度：
  1.001±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-acetoxy-2,2-dimethyl-propionitrile 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 3-氰基-3-甲基丁酰氯
  参考文献：
  名称：

  Kern,J.M.; Federli,P., Bulletin de la Societe Chimique de France, 1972, p. 4379 - 4383

  摘要：

  DOI：
• 作为产物：
  描述：

  2,2-二甲基-3-羟基丙醛 在 盐酸羟胺 作用下， 生成 3-acetoxy-2,2-dimethyl-propionitrile
  参考文献：
  名称：

  Kern,J.M.; Federli,P., Bulletin de la Societe Chimique de France, 1972, p. 4379 - 4383

  摘要：

  DOI：

文献信息

• Second messenger-dependent protein kinases and protein synthesis regulate endogenous secretin receptor responsiveness
  作者：Roxana S Ghadessy、Eamonn Kelly

  DOI：10.1038/sj.bjp.0704655

  日期：2002.4

  The present study investigated the role of second messenger‐dependent protein kinase A (PKA) and C (PKC) in the regulation of endogenous secretin receptor responsiveness in NG108‐15 mouse neuroblastoma×rat glioma hybrid cells.In whole cell cyclic AMP accumulation studies, activation of PKC either by phorbol 12‐myristate 13‐acetate (PMA) or by purinoceptor stimulation using uridine 5′‐triphosphate (UTP) decreased secretin receptor responsiveness. PKC activation also inhibited forskolin‐stimulated cyclic AMP accumulation but did not affect cyclic AMP responses mediated by the prostanoid‐IP receptor agonist iloprost, or the A2adenosine receptor agonist 5′‐(N‐ethylcarboxamido) adenosine (NECA).In additivity experiments, saturating concentrations of secretin and iloprost were found to be additive in terms of cyclic AMP accumulation, whereas saturating concentrations of NECA and iloprost together were not. This suggests compartmentalization of Gs‐coupling components in NG108‐15 cells and possible heterologous regulation of secretin receptor responsiveness at the level of adenylyl cyclase activation.Cells exposed to the PKA inhibitor H‐89, exhibited a time‐dependent increase in secretin receptor responsiveness compared to control cells. This effect was selective since cyclic AMP responses to forskolin, iloprost and NECA were not affected by H‐89 treatment. Furthermore, treatment with the protein synthesis inhibitor cycloheximide produced a time‐dependent increase in secretin receptor responsiveness.Together these results indicate that endogenous secretin receptor responsiveness is regulated by PKC, PKA and protein neosynthesis in NG108‐15 cells.British Journal of Pharmacology(2002)135, 2020–2028; doi:10.1038/sj.bjp.0704655
• PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY
  申请人：VERA THERAPEUTICS, INC.

  公开号：US20210206809A1

  公开（公告）日：2021-07-08

  This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.