diethyl 2-hydroxy-2-(4-methoxyphenyl)propylphosphonate | 1334049-14-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: diethyl 2-hydroxy-2-(4-methoxyphenyl)propylphosphonate
• 英文别名: 1-[Diethoxy(oxido)phosphaniumyl]-2-(4-methoxyphenyl)propan-2-ol；1-[diethoxy(oxido)phosphaniumyl]-2-(4-methoxyphenyl)propan-2-ol
• CAS: 1334049-14-7
• 化学式: C₁₄H₂₃O₅P
• 分子量: 302.307
• InChiKey: UIOHIFBVUBBWCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  phosphorohydrazidic acid diethyl ester 、 1-异丙烯基-4-甲氧基苯 在 铁酞菁 、 氧气 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以82%的产率得到diethyl 2-hydroxy-2-(4-methoxyphenyl)propylphosphonate
  参考文献：
  名称：

  Synthesis of β-hydroxyphosphonates by iron-catalyzed oxidative addition of phosphonyl radicals to alkenes

  摘要：

  Phosphorohydrazidates have been shown to work as radical precursors by iron-catalyzed aerobic oxidation to generate corresponding phosphonyl radicals. Generated radicals cause intermolecular addition to various alkenes in the presence of molecular oxygen to give beta-hydroxyphosphonate compounds in good yield. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.026

文献信息

• Synthesis of β-hydroxyphosphonates by iron-catalyzed oxidative addition of phosphonyl radicals to alkenes
  作者：Tsuyoshi Taniguchi、Atsushi Idota、Shin’ichi Yokoyama、Hiroyuki Ishibashi

  DOI：10.1016/j.tetlet.2011.07.026

  日期：2011.9

  Phosphorohydrazidates have been shown to work as radical precursors by iron-catalyzed aerobic oxidation to generate corresponding phosphonyl radicals. Generated radicals cause intermolecular addition to various alkenes in the presence of molecular oxygen to give beta-hydroxyphosphonate compounds in good yield. (C) 2011 Elsevier Ltd. All rights reserved.