3-(1-methoxycarbonyl-2-oxo-cyclohexyl)-propionic acid methyl ester | 75844-17-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(1-methoxycarbonyl-2-oxo-cyclohexyl)-propionic acid methyl ester
• 英文别名: (+/-)-1-(2-Methoxycarbonyl-aethyl)-2-oxo-cyclohexancarbonsaeure-methylester；3-(1-Methoxycarbonyl-2-oxo-cyclohexyl)-propionsaeure-methylester；Cyclohexanepropanoic acid, 1-(methoxycarbonyl)-2-oxo-, methyl ester；methyl 1-(3-methoxy-3-oxopropyl)-2-oxocyclohexane-1-carboxylate
• CAS: 75844-17-6
• 化学式: C₁₂H₁₈O₅
• 分子量: 242.272
• InChiKey: OFRYMLNXTYIBLN-UHFFFAOYSA-N

物化性质

• 沸点：
  150-155 °C(Press: 15 Torr)
• 密度：
  1.137±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-溴丙酸甲酯 、 2-氧环己烷羧酸甲酯 在 sodium ethanolate 作用下， 生成 3-(1-methoxycarbonyl-2-oxo-cyclohexyl)-propionic acid methyl ester
  参考文献：
  名称：

  New Compounds. Some Derivatives of 2-Carbomethoxycyclohexanone

  摘要：

  DOI：

  10.1021/ja01142a602

文献信息

• Surface-mediated solid phase michael reaction: dramatic acceleration on alumina
  作者：Brindaban C. Ranu、Sanjay Bhar、Dipak C. Sarkar

  DOI：10.1016/0040-4039(91)85093-k

  日期：1991.6

  The Michael reaction of several β-dicarbonyl compounds, ethyl cyanoacetate, and diethyl malonate as donors with methyl vinyl ketone, acrolein and methyl acrylate as acceptors are carried out very efficiently on Al2O3 surface without any solvent.

  几种β-二羰基化合物，氰基乙酸乙酯和丙二酸二乙酯（作为供体）与甲基乙烯基酮，丙烯醛和丙烯酸甲酯作为受体的迈克尔反应非常有效地在Al 2 O 3表面上进行，而无需任何溶剂。
• Zeolite mediated michael addition of 1,3-dicarbonyl compounds and thiols
  作者：R. Sreekumar、P. Rugmini、Raghavakaimal Padmakumar

  DOI：10.1016/s0040-4039(97)01494-9

  日期：1997.9

  Zeolites, an environmentally attractive solid catalyst, proves to be an efficient catalyst for Michael addition of several 1, 3-dicarbonyl compounds and thiols as donors with methyl vinyl ketone, acrolein and methyl acrylate as acceptors without any solvent are described.

  沸石，一种对环境有吸引力的固体催化剂，被证明是一种有效的催化剂，用于迈克尔加成几种1，3-二羰基化合物和硫醇作为供体，其中描述了甲基乙烯基酮，丙烯醛和丙烯酸甲酯作为受体，没有任何溶剂。
• Evidence for organoironcarbonylate anion formation in nucleophilic addition to tetracarbonyliron complexes of acrylate esters
  作者：Bryan W. Roberts、Mark Ross、Janice Wong

  DOI：10.1039/c39800000428

  日期：——

  Sequential addition of stabilized anions and alkyl iodides to tetracarbonyliron complexes of methyl acrylate and methyl crotonate affords products consistent with regiospecific generation and alkylation of an organoironcarbonylate anion intermediate.

  向丙烯酸甲酯和巴豆酸甲酯的四羰基铁络合物中顺序加入稳定化的阴离子和烷基碘化物，得到的产物与有机铁羰基化阴离子中间体的区域特异性生成和烷基化相一致。
• Surface-mediated solid phase reaction: Dramatic improvement of Michael reaction on the surface of alumina
  作者：Brindaban C. Ranu、Sanjay Bhar

  DOI：10.1016/s0040-4020(01)90794-x

  日期：1992.1

  The Michael reaction of several 1,3-dicarbonyl compounds, nitroalkanes, and thiols as donors with methyl vinyl ketone, acrolein, methyl acrylate, methyl methacrylate, and mesityl oxide as acceptors on the surface of alumina without any solvent proceed very effeciently and furnish high yield of adducts.
• ROBERTS B. W.; ROSS M.; WONG J., J. CHEM. SOC. CHEM. COMMUN., 1980, NO 10, 428-429
  作者：ROBERTS B. W.、 ROSS M.、 WONG J.

  DOI：——

  日期：——