9(4-methoxyphenyl)nonanoic acid | 62325-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 9(4-methoxyphenyl)nonanoic acid
• 英文别名: 9-(4-methoxyphenyl)nonanoic acid
• CAS: 62325-93-3
• 化学式: C₁₆H₂₄O₃
• 分子量: 264.365
• InChiKey: IPLRWTIZDFQTEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  9(4-methoxyphenyl)nonanoic acid 在 硼烷四氢呋喃络合物 作用下， 生成 9-(4-methoxyphenyl)-nonan-1-ol
  参考文献：
  名称：

  Antiviral activity of some .beta.-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses

  摘要：

  The discovery that 4-[3-ethyl-6-[(3,4-methylenedioxy)phenyl]-3-hexenyl]-3,5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure--activity study to establish the criteria for optimum activity. Modification of the bridge included removal of the ethyl group and reduction of the double bond. The heptanedione was replaced with hexanedione and pentanedione with a minimal effect. The effect of replacing the heptanedione with beta-keto esters and monoketones was also investigated. Maintaining the hexamethylene bridge and heptanedione, the methylenedioxy group was replaced with various substitutents. In general, most substituents did not adversely affect activity particularly against equine rhinovirus although there was some variation in activity against herpesvirus. Strongly hydrophilic groups significantly reduced activity. Finally, the effect of varying the length of the alkyl bridge was examined in the 4-hydroxyphenyl series, where peak activity was attained with n = 8.

  DOI：

  10.1021/jm00216a003
• 作为产物：
  描述：

  9(4-methoxyphenyl)-7-ketononanoic acid 在 氢氧化钾 、 一水合肼 作用下， 以 氯仿 、 水 、 二乙二醇 为溶剂， 以38%的产率得到9(4-methoxyphenyl)nonanoic acid
  参考文献：
  名称：

  Lipoxygenase inhibitory compounds

  摘要：

  式为##STR1##的化合物，其中n=6-11，M为氢或药用可接受的阳离子，R为氢或C.sub.1 -C.sub.6烷基，可以选择地被羧基取代，而X.sub.a、X.sub.b和X.sub.c分别独立地表示氢或多种取代基团，是5-脂氧合酶的强效抑制剂。

  公开号：

  US04861798A1

文献信息

• 一种烷基酚半抗原的合成方法
  申请人：深圳容金科技有限公司

  公开号：CN114989002A

  公开（公告）日：2022-09-02

  本发明属于精细化工合成技术领域，公开了一种烷基酚半抗原的合成方法，包括以下步骤：一、化合物A的合成：将壬基酚、四氯乙烯加热，当溶液温度上升到40℃时，开始滴加乙酰氯的四氯乙烯溶液，反应完毕后，将过量的乙酰氯蒸出，缓慢向溶液中加入定量NaHCO3溶液直至溶液pH=7，中和完毕后，搅拌、静置和分层，将油层水洗至中性，减压蒸馏，收集0.01MPa下220℃时的馏分，得到化合物A。本方案用化学合成的方法设计合成出具有免疫原性的壬基酚人工半抗原分子从而诱导产生特异性强、免疫性高、灵敏度高的抗体，为烷基酚的半抗原的合成方法提供更多选择，得到的壬基酚类似物，可作为酶联免疫分析方法中的前体，具有很高的使用价值。
• TRAMPOSCH, KENNETH M.;ZUSI, FRED C.;MARATHE, SURESH A.
  作者：TRAMPOSCH, KENNETH M.、ZUSI, FRED C.、MARATHE, SURESH A.

  DOI：——

  日期：——
• Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells
  作者：Takuya Okada、Yuri Chino、Keita Yokoyama、Yuki Fujihashi、Nguyễn Duy Phan、Juthamart Maneenet、Lanke Prudhvi、Suresh Awale、Naoki Toyooka

  DOI：10.1016/j.bmc.2022.116963

  日期：2022.10
• US4861798A
  申请人：——

  公开号：US4861798A

  公开（公告）日：1989-08-29
• Antiviral activity of some .beta.-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses
  作者：Guy D. Diana、U. Joseph Salvador、Ethel S. Zalay、Robert E. Johnson、Joseph C. Collins、David Johnson、William B. Hinshaw、Roman R. Lorenz、William H. Thielking、Francis Pancic

  DOI：10.1021/jm00216a003

  日期：1977.6

  The discovery that 4-[3-ethyl-6-[(3,4-methylenedioxy)phenyl]-3-hexenyl]-3,5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure--activity study to establish the criteria for optimum activity. Modification of the bridge included removal of the ethyl group and reduction of the double bond. The heptanedione was replaced with hexanedione and pentanedione with a minimal effect. The effect of replacing the heptanedione with beta-keto esters and monoketones was also investigated. Maintaining the hexamethylene bridge and heptanedione, the methylenedioxy group was replaced with various substitutents. In general, most substituents did not adversely affect activity particularly against equine rhinovirus although there was some variation in activity against herpesvirus. Strongly hydrophilic groups significantly reduced activity. Finally, the effect of varying the length of the alkyl bridge was examined in the 4-hydroxyphenyl series, where peak activity was attained with n = 8.