9-(4-pyridyl)phenanthreno<9,10-d>-1,3-oxazole | 151457-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 9-(4-pyridyl)phenanthreno<9,10-d>-1,3-oxazole
• 英文别名: 2-(4-pyridyl)-phenanthro<9,10-d>oxazole；2-(pyridin-4-yl)phenanthro[9,10-d]oxazole；2-Pyridin-4-ylphenanthro[9,10-d][1,3]oxazole
• CAS: 151457-91-9
• 化学式: C₂₀H₁₂N₂O
• 分子量: 296.328
• InChiKey: VDUOJYNHGPRUEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-nitrosophenanthren-9-ol 在 palladium on activated charcoal 盐酸 、 氢气 、 三氯氧磷 作用下， 反应 26.0h， 生成 9-(4-pyridyl)phenanthreno<9,10-d>-1,3-oxazole
  参考文献：
  名称：

  Hall, J. Herbert; Chien, Joseph Yuming; Kauffman, Joel M., Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1245 - 1273

  摘要：

  DOI：

文献信息

• Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions without labels
  申请人：——

  公开号：US20020127563A1

  公开（公告）日：2002-09-12

  A surface-selective nonlinear optical technique, such as second harmonic or sum frequency generation, is used to detect target-probe binding reactions or their effects, at an interface, without the use of labels. In addition, the direction of the nonlinear light is scattered from the interface in a well-defined direction and therefore its incidence at a detector some distance from the interface may be easily mapped to a specific and known location at the interface.

  表面选择性非线性光学技术（如二次谐波或和频发生）可用于检测界面上的目标-探针结合反应或其效应，而无需使用标签。此外，非线性光从界面散射的方向是明确的，因此它在距离界面一定距离的检测器上的入射点可以很容易地映射到界面上特定的已知位置。
• Method using a nonlinear optical technique for detection of interactions involving a conformational change
  申请人：——

  公开号：US20030148391A1

  公开（公告）日：2003-08-07

  A nonlinear optical technique, such as second or third harmonic or sum or difference frequency generation, is used to detect binding interactions, or the degree or extent of binding, that comprise a conformational change. In one aspect of the present invention, the nonlinear optical technique detects a conformational change in a probe due to target binding. In another aspect of the invention, the nonlinear optical technique screens candidate probes by detecting a conformational change due to a probe-target interaction. In another aspect of the invention, the nonlinear optical technique screens candidate modulators of a probe-target interaction by detecting a conformational change in the presence of the modulator.

  非线性光学技术，如二次或三次谐波或总频或差频发生技术，可用于检测包含构象变化的结合相互作用或结合程度或范围。在本发明的一个方面，非线性光学技术可检测探针因目标结合而发生的构象变化。在本发明的另一方面，非线性光学技术通过检测探针与目标相互作用引起的构象变化来筛选候选探针。在本发明的另一方面，非线性光学技术通过检测存在调制器时的构象变化来筛选探针与目标相互作用的候选调制器。
• Design of labels for detection with a surface-seletive nonlinear optical technique
  申请人：——

  公开号：US20040146460A1

  公开（公告）日：2004-07-29

  Second harmonic, sum and difference frequency generation can be used to detect a variety of processes, which are otherwise undetectable, using nonlinear-active labels. The labels must have as high a hyperpolarizability as possible. Several designs for large hyperpolarizability second-harmonic active labels are described herein. These labels can be attached to any target molecule or particle, resulting in more highly nonlinear-optically active targets.

  利用非线性有源标签，二次谐波、和差频率生成可用于检测各种过程，否则无法检测。标签必须具有尽可能高的超极化率。本文介绍了几种大超极化率二次谐波有源标签的设计。这些标签可以附着在任何目标分子或粒子上，从而产生更高的非线性光学活性目标。
• DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles
  作者：Debasish Bera、Rajib Sarkar、Tiyasa Dhar、Pinaki Saha、Prasanta Ghosh、Chhanda Mukhopadhyay

  DOI：10.1039/d4ob00383g

  日期：——

  (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined. This protocol is operationally simple and leads to various functionalized substituted imidazoles or oxazoles in good yields. To date, a very limited number of oxidation protocols have been established, where DMSO acts solely as a catalyst or an oxidant or both. In this report, DMSO is not only used

  概述了二甲亚砜 (DMSO) 促进的无催化剂氧化 C-N 偶联和无氧化剂条件下的 C-O 偶联。该方案操作简单，并且以良好的产率产生各种官能化的取代咪唑或恶唑。迄今为止，已经建立的氧化方案数量非常有限，其中 DMSO 仅充当催化剂或氧化剂或两者兼而有之。在本报告中，DMSO不仅用作C-N/C-O偶联剂，还用作这些氧化转化所需的氧化剂。因此，我们所证明的 DMSO 促进的无催化剂偶联转化有能力引领氧化偶联领域的新维度。
• Synthesis of phenanthro[9, 10-d]oxazoles from 10-(methoxyimino)phenanthrene-9-one
  作者：Demetrios N. Nicolaides、Evangelia A. Varella、R. Wajih Awad

  DOI：10.1016/s0040-4020(01)87251-3

  日期：1993.8

  10-(Methoxyimino)phenanthren-9-one 3 easily reacts with the methyl substituted aromatics 4(a-d), as well as with alpha-bromo-p-xylene 6 and the alpha-substituted methyl derivatives 7(a-i), to afford in 5-64% yield the corresponding 2-aryl substituted phenanthro[9,10-d]oxazoles 5(a-g), most probably via a free radical reaction sequence. In several cases the unsubstituted oxazole 12 is also obtained, while reaction of compound 3 with the N-methyl substituted amines 7g and 14(ab) leads to the aminooxazoles 13 and 15(a,b) respectively.