2-(2,3-Dimethylphenyl)-5-ethylsulfonyl-1,3-benzoxazole | 1045739-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2,3-Dimethylphenyl)-5-ethylsulfonyl-1,3-benzoxazole
• CAS: 1045739-31-8
• 化学式: C₁₇H₁₇NO₃S
• 分子量: 315.393
• InChiKey: WWDSGOXUKAXUBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-4-(乙硫酰基)苯酚 、 2,3-二甲基苯甲酸 在 PPA 作用下， 反应 2.5h， 以21%的产率得到2-(2,3-Dimethylphenyl)-5-ethylsulfonyl-1,3-benzoxazole
  参考文献：
  名称：

  Synthesis and biological activity of some new benzoxazoles

  摘要：

  The synthesis and antimicrobial activity of a new series of 5-ethylsulphonyl-2-(substituted-phenyl/substituted-benzyl and/or phenylethyl)benzoxazole derivatives (3a-3t) except 3a, 3g, 3h, 3k [R.S. Pottorf, N.K. Chadha, M. Katkevies, V. Ozola, E. Suna, H. Ghane, T. Regberg, M.R. Player, Tetrahedron Lett. 44 (1) (2003) 175] were described. The in vitro antimicrobial activity of the compounds was determined against some Gram-positive, Gram-negative bacteria, a fungi Candida albicans and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicated that the synthesized compounds possessed a broad spectrum of activity with MIC values 250-7.81 mu g/ml. While all compounds are less potent than fluconazole against C. albicans, most of them are more potent than fluconazole against C. albicans isolate. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.09.023