2,5,6-trimethyl-cyclohex-3-enecarbaldehyde | 693782-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: 2,5,6-trimethyl-cyclohex-3-enecarbaldehyde
• 英文别名: 2,5,6-Trimethyl-cyclohex-3-encarbaldehyd；1-Formyl-2.3.6-trimethyl-cyclohexen-(4)；2,5,6-Trimethylcyclohex-3-ene-1-carbaldehyde；2,5,6-trimethylcyclohex-3-ene-1-carbaldehyde
• CAS: 693782-40-0
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: ITRNPAHSAMWGNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5,6-trimethyl-cyclohex-3-enecarbaldehyde 在 镍 作用下， 生成 (2,3,6-Trimethyl-cyclohexyl)-methanol
  参考文献：
  名称：

  p16INK4a Is Selectively Silenced in the Tumoral Progression of Mycosis Fungoides

  摘要：

  Knowledge about the molecular mechanisms involved in the pathogenesis of tumoral progression in mycosis fungoides (MF) is still scarce. Because the 9p21 locus seems to be a good target for a detailed study in MF, this prompted us to compare the mechanisms of inactivation of the p16(INK4a), p15(INK4b), and p14(ARF) genes in aggressive and stable forms of MF, performing microsatellite analysis, methylation-specific polymerase chain reaction, direct sequencing, and p16(INK4a) protein expression by immunohistochemistry. Additionally, the p53 gene was also sequenced in tumoral lesions. Thirty-nine patients with stable MF were studied. Alterations in p16(INK4a) and p15(INK4b) genes were detected in 18% and 5% of the cases, respectively. None of the cases analyzed showed alterations of the p14(ARF) gene. in contrast with these findings, in the 11 patients with aggressive MF, alterations of the p16(INK4a), p15(INK4b), or p14(ARF) genes were found in 8 (73%), 3 (27%), and 2 (18%) cases, respectively. A significant proportion (4/11) of these alterations were already present in the p16(INK4a) gene in the initial plaque lesions in these aggressive forms of MF. Alterations in the p16(INK4a) gene, either methylation or loss of heterozygosity, were clearly more frequent than those in the p15(INK4b) and p14(ARF) genes. These p16(INK4A) alterations were confirmed using immunohistochemistry. None of the nine tumoral lesions analyzed showed mutations in exons 1-2 of the p16(INK4a) gene or in exons 5-8 of the p53 gene. These results seem to suggest that 9p21 alterations, and selectively p16(INK4a) silencing, could be a characteristic phenomenon in MF progression.

  DOI：

  10.1038/labinvest.3780405
• 作为产物：
  描述：

  巴豆醛 、 2,4-己二烯 生成 2,5,6-trimethyl-cyclohex-3-enecarbaldehyde
  参考文献：
  名称：

  Arbusow; Sinowjewa; Fink, Zhurnal Obshchei Khimii, 1937, vol. 7, p. 2278,2290

  摘要：

  DOI：

文献信息

• Freshening compositions and devices comprising same
  申请人：The Procter & Gamble Company

  公开号：US10113140B2

  公开（公告）日：2018-10-30

  The present invention relates to freshening compositions and devices comprising same that comprise a composition comprising malodor reduction compositions and methods of making and using such compositions. Such malodor control technologies do not unduely interfere with the scent of the perfumed or unperfumed situs that is treated with the malodor control technology.

  本发明涉及由包含减少恶臭组合物的组合物组成的清新组合物和装置，以及制造和使用这种组合物的方法。这种恶臭控制技术不会不适当地干扰用恶臭控制技术处理的有香味或无香味部位的香味。
• Schorygin; Gussewa, Zhurnal Obshchei Khimii, 1936, vol. 6, p. 1569,1576
  作者：Schorygin、Gussewa

  DOI：——

  日期：——
• CH143243
  申请人：——

  公开号：——

  公开（公告）日：——
• FRESHENING COMPOSITIONS AND DEVICES COMPRISING SAME
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP3197426A1

  公开（公告）日：2017-08-02
• CLEANING AND/OR TREATMENT COMPOSITIONS COMPRISING MALODOR REDUCTION COMPOSITIONS
  申请人：The Procter & Gamble Company

  公开号：EP3197422A1

  公开（公告）日：2017-08-02