3,6-dimethyl-cyclohex-4-ene-1,2-dicarboxylic acid anhydride | 2651-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异苯并呋喃
• 英文名称: 3,6-dimethyl-cyclohex-4-ene-1,2-dicarboxylic acid anhydride
• 英文别名: 3,6-Dimethyl-cyclohex-4-en-1,2-dicarbonsaeure-anhydrid；1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-4,7-dimethyl-；4,7-dimethyl-3a,4,7,7a-tetrahydro-2-benzofuran-1,3-dione
• CAS: 2651-48-1
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: UKVSOXGGGOPLAE-UHFFFAOYSA-N

物化性质

• 熔点：
  96 °C
• 沸点：
  304.7±42.0 °C(Predicted)
• 密度：
  1.140±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,6-dimethyl-cyclohex-4-ene-1,2-dicarboxylic acid anhydride 生成 3,6-dimethylcyclohexane-1,2-dicarboxylic acid anhydride
  参考文献：
  名称：

  ISIDZUMI, KIKUO;YASUNORI, FUDZIO;MARUYAMA, ISAMU;KODZIMA, ATSUYUKI

  摘要：

  DOI：
• 作为产物：
  描述：

  马来酸酐 、 2,4-己二烯 在 苯 作用下， 生成 3,6-dimethyl-cyclohex-4-ene-1,2-dicarboxylic acid anhydride
  参考文献：
  名称：

  Diels; Alder, Justus Liebigs Annalen der Chemie, 1929, vol. 470, p. 103

  摘要：

  DOI：

文献信息

• Succinimide derivatives and their production
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0109562A1

  公开（公告）日：1984-05-30

  A succinimide derivative of the formula: wherein A is straight or branched C2-C6 alkylene or alkenylene, B is straight or branched C3-C5 alkylene, D is straight or branched C2-C3 alkylene, E is straight or branched C2-C3 alkylene, R1 and R2 are each hydrogen or C1-C4 alkyl, or they may form a single bond and R3 is a phenyl group optionally substituted with C1-C4 alkyl, C1-C4 alkoxy, halogen and or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: (in which R4 is hydrogen or phenyl), a group of the formula: CO-R5 (in which R5 is adamantyl or furyl) or hydroxy(C2-C4)alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.

  一种琥珀酰亚胺衍生物，其式如下 其中 A 为直链或支链 C2-C6 亚烷基或烯基，B 为直链或支链 C3-C5 亚烷基，D 为直链或支链 C2-C3 亚烷基，E 为直链或支链 C2-C3 亚烷基，R1 和 R2 各为氢或 C1-C4 烷基，或它们可形成单键，R3 为任选被 C1-C4 烷基、C1-C4 烷氧基、卤素和或三氟甲基取代的苯基，任选被卤素取代的 2-吡啶基，任选被卤素取代的 2-嘧啶基，式中的一个基团： (其中 R4 为氢或苯基）、式中的一个基团： CO-R5（其中 R5 为金刚烷基或呋喃基）或羟基（C2-C4）烷基，以及它们的酸加成盐，可用作抗焦虑药和/或抗过敏药。
• Process for preparing advanced epoxy resin compositions
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0209174A2

  公开（公告）日：1987-01-21

  A pre-catalyzed epoxy resin composition comprising: a) a polyepoxide, and b) a catalytic amount of a catalyst selected from the group consisting of wherein R is a hydrocarbyl or inertly substituted hydrocarbyl group and X is a compatible anion.

  一种预催化环氧树脂组合物，包括 a) 一种聚环氧化物，和 b) 催化量的选自以下组别的催化剂 其中 R 为烃基或惰性取代的烃基，X 为相容阴离子。
• ALICYCLIC DICARBOXYLIC ACID DERIVATIVES AND MUSCLE RELAXANTS CONTAINING THEM AS EFFECTIVE INGREDIENTS
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0302934A1

  公开（公告）日：1989-02-15

  Alicyclic dicarboxylic acid derivatives represented by (wherein A represents (ll) or (lll), R, and R2 in (ll) or (lll) each represents a hydrogen atom or a lower alklyl group, with at least one of R1 and R2 being a lower alkyl group, and - represents a single or double bond) and salts thereof, and muscle relaxants containing said alicyclic dicarboxylic acid derivatives or pharmacologically acceptable salts thereof as effective ingredients are disclosed. The drugs are effective in treating spastic paralysis, lumbodorsalgia, herniation of the intervertebral disk, spondylolysis, osteoporosis, neck-shoulder-arm syndrome, etc.

  脂环族二羧酸衍生物，其代表为 (其中 A 代表 (ll) 或 (lll)，(ll) 或 (lll) 中的 R 和 R2 各代表氢原子或低级烷基，R1 和 R2 中至少有一个是低级烷基，- 代表单键或双键）及其盐，以及含有上述脂环族二羧酸衍生物或其药理学上可接受的盐作为有效成分的肌肉松弛剂。这些药物可有效治疗痉挛性瘫痪、腰背痛、椎间盘突出症、脊柱溶解症、骨质疏松症、颈肩臂综合征等。
• Epoxy resins containing phosphonium catalysts
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0360195A2

  公开（公告）日：1990-03-28

  Epoxide compounds and phenolic compounds are reacted in the presence of phosphonium compounds represented by the formula ⊖Z′R¹R²R³P⊕-Z-P⊕R¹R²R³Z′⊖ wherein each R¹, R² amd R³ is independently an aromatic group or an inertly substituted aromatic group; Z is -(C(R⁴)₂a-; each R⁴ is independently hydrogen or a hydrocarbyl group containing from 1 to 20 carbon atoms; Z′ is any suitable anion and a has a value of at least 4.

  环氧化合物和酚类化合物在由式⊖Z′R¹R²R³P⊕-Z-P⊕R¹R²R³Z′⊖代表的鏻化合物存在下反应 其中每个 R¹、R²和 R³ 独立地是芳香基团或惰性取代的芳香基团；Z 是-(C(R⁴)₂a-；每个 R⁴ 独立地是氢或含有 1 至 20 个碳原子的烃基；Z′ 是任何合适的阴离子，且 a 的值至少为 4。
• Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
  申请人：BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC.

  公开号：EP0411333A1

  公开（公告）日：1991-02-06

  Disclosed herein are tetrapeptide derivatives of the formula X-­NH-CHR¹-C(W¹)-NR²-CH[CH₂C(O)-Y]-C(W²)-NH-CH[CR³(R⁴)-­COOH]-C(W³)-NH-CHR⁵-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R¹ and R⁵ are selected from amino acid or derived amino acid residues, R² is hydrogen, alkyl or phenylalkyl, R³ and R⁴ are hydrogen or alkyl or R³ and R⁴ are joined to form a cycloalkyl, W¹, W² and W³ are oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COOH or CH₂OH. The derivatives are useful for treating herpes infections.

  本文公开了式 X-NH-CHR¹-C(W¹)-NR²-CH[CH₂C(O)-Y]-C(W²)-NH-CH[CR³(R⁴)-COOH]-C(W³)-NH-CHR⁵-Z 的四肽衍生物，其中 X 为末端基团、R¹ 和 R⁵ 选自氨基酸或衍生氨基酸残基、R²为氢、烷基或苯基烷基，R³和R⁴为氢或烷基，或R³和R⁴连接形成环烷基，W¹、W²和W³为氧代或硫代，Y为例如烷氧基或单取代或二取代氨基，Z为末端单元，例如氢、COOH或CH₂OH。这些衍生物可用于治疗疱疹感染。