2-(4-chlorophenyl)-5-(2-(4-chlorophenyl)thiazol-4-yl)-4-methylthiazole | 61108-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-chlorophenyl)-5-(2-(4-chlorophenyl)thiazol-4-yl)-4-methylthiazole
• 英文别名: 2,2'-bis-(4-chloro-phenyl)-4'-methyl-[4,5']bithiazolyl；2-(4-Chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazole
• CAS: 61108-33-6
• 化学式: C₁₉H₁₂Cl₂N₂S₂
• 分子量: 403.356
• InChiKey: CLURNUYLUHOURI-UHFFFAOYSA-N

物化性质

• 熔点：
  209-210 °C(Solv: benzene (71-43-2))
• 沸点：
  568.6±60.0 °C(Predicted)
• 密度：
  1.386±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  82.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯硫代苯甲酰胺 在 溴 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 6.0h， 生成 2-(4-chlorophenyl)-5-(2-(4-chlorophenyl)thiazol-4-yl)-4-methylthiazole
  参考文献：
  名称：

  Sawhney,S.N.; Arora,S.K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1976, vol. 14, p. 552 - 555

  摘要：

  DOI：

文献信息

• Synthesis and biological screening of 2′-aryl/benzyl-2-aryl-4-methyl-4′,5-bithiazolyls as possible anti-tubercular and antimicrobial agents
  作者：Yogita K. Abhale、Amit V. Sasane、Abhijit P. Chavan、Keshav K. Deshmukh、Sudha Sravanti Kotapalli、Ramesh Ummanni、Sadikali F. Sayyad、Pravin C. Mhaske

  DOI：10.1016/j.ejmech.2015.03.016

  日期：2015.4

  A series of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyl derivatives, 25-64 were synthesized and evaluated for inhibitory activity against Mycobacterium smegmatis MC2 155 strain and antimicrobial activities against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli. and Proteus vulgaris. Among them, compounds 40, 49, 50, and 54 exhibited moderate to good inhibition on the growth of the bacteria Mycobacterium smegmatis at the concentration of 30 mu M. Compounds 26, 40, 44, 54 and 56 exhibited moderate to good antibacterial activity. Compound 5-(2'-(4-fluorobenzyl)thiazol-4'-yl)-2-(4-fluorophenyl)-4-methyl-thiazole (54) exhibited both antitubercular as well as antimicrobial activity against all tested strains. (C) 2015 Elsevier Masson SAS. All rights reserved.