N-(3,5-di-t-butyl-4-hydroxyphenyl)-N'-aminooxamide | 121080-79-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(3,5-di-t-butyl-4-hydroxyphenyl)-N'-aminooxamide
• 英文别名: 2-(3,5-di-t-butyl-4-hydroxyphenylamino)-2-oxoacetyl hydrazide；N-(3,5-ditert-butyl-4-hydroxyphenyl)-2-hydrazinyl-2-oxoacetamide
• CAS: 121080-79-3
• 化学式: C₁₆H₂₅N₃O₃
• 分子量: 307.393
• InChiKey: JSZIPTOCXGVZFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl N-(2,2,6,6-tetramethyl-4-piperidinyl)oxamate 、 N-(3,5-di-t-butyl-4-hydroxyphenyl)-N'-aminooxamide 以 甲醇 为溶剂， 生成 1-[N-(2,2,6,6-tetramethyl-4-piperidinyl)oxamoyl]-2-[N-(3,5-di-t-butyl-4-hydroxyphenyl)oxamoyl]hydrazine
  参考文献：
  名称：

  Derivatives of N-HALS-substituted amic acid hydrazides

  摘要：

  N-(2,2,6,6-四烷基-4-哌啶基)酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸酰肼酸

  公开号：

  US05338853A1
• 作为产物：
  描述：

  ethyl 2-(3,5-di-t-butyl-4-hydroxyphenylamino)-2-oxoacetate 在 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 以2.8 g (45.5%)的产率得到N-(3,5-di-t-butyl-4-hydroxyphenyl)-N'-aminooxamide
  参考文献：
  名称：

  Phenolic antioxidant hydrazides

  摘要：

  提供了酚类抗氧化剂肼，可用于稳定易受氧化降解的有机材料（例如合成高分子材料）。

  公开号：

  US04801749A1

文献信息

• Derivatives of N-hals-substituted amic acid hydrazides
  申请人：Elfatochem North America, Inc.

  公开号：US05397821A1

  公开（公告）日：1995-03-14

  N-(2,2,6,6-tetraalkyl-4-piperidinyl)amic acid hydrazides contain a light stabilizing group, a heat stabilizing group and an amic acid hydrazide functionality in the same molecule. The amic acid hydrazide functionality in the compounds enhances the photooxidative stabilizing properties of the hindered amine groups and contributes thermal and oxidative stabilizing and metal complexing properties to the compounds. The novel compounds are excellent light stabilizers for polyolefins, have low volatility and are not readily lost from polymeric systems via volatilization, migration or extraction.

  N-(2,2,6,6-四烷基-4-哌啶基)酰肼化合物包含光稳定基团、热稳定基团和酰肼基团在同一分子中。化合物中的酰肼基团增强了受阻胺基团的光氧化稳定性，并为化合物提供了热稳定、氧化稳定和金属络合性质。这些新型化合物是聚烯烃的优秀光稳定剂，具有低挥发性，并且不容易通过挥发、迁移或提取从聚合体系中丢失。
• Multipurpose polymer bound stabilizers
  申请人：ATOCHEM NORTH AMERICA, INC.

  公开号：EP0303986A2

  公开（公告）日：1989-02-22

  These are provided polymer bound stabilizers with recurring units selected from the formulas or both wherein the units occur, e.g., in the polymer back­bone, x is 0 or 1, R¹ and R² are, e.g., hydrogen, and each -- is the residue of a primary amino or hydrazido substituted stabilizer group selected from (a) hindered phenols, (b) hindered amine light stabilizers, (c) 2-hydroxybenzophenones, (d) 2-(2-hydroxyphenyl)-2H-benzotriazoles, (e) secondary aromatic amines, (f) benzothiazoles or benzimidazoles, (g) aryl salicylates, (h) salicylic acid derivatives (i) oxamide derivatives and (j) dialkyl sulfides, with the proviso that at least two different groups from (a) through (j) are attahced to the polymer. The polymeric stabilizers are prepared by the reaction of primary amino or hydrazido substituted stabilizers with some or all of the anhydride groups of the polymer or copolymer. They are not lost from the polymer by volatilization, migration or extraction, even at high temperature and may be used as concentrates to stabilize other polymers.

  这些聚合物结合稳定剂具有选自下列公式的重复单元 或两者，其中单元出现在聚合物骨架等处，x 为 0 或 1，R¹ 和 R² 为氢等，且每 -- 是伯氨基或肼基取代的稳定剂基团的残基，选自 (a) 受阻酚，(b) 受阻胺光稳定剂，(c) 2-羟基二苯甲酮，(d) 2-(2-羟基苯基)-2H-苯并三唑，(e) 仲芳香胺、(f) 苯并噻唑或苯并咪唑； (g) 芳基水杨酸盐； (h) 水杨酸衍生物； (i) 草酰胺衍生物；以及 (j) 二烷基硫化物，但聚合物中至少含有两个不同的(a)至(j)基团。聚合物稳定剂是通过伯氨基或肼基取代的稳定剂与聚合物或共聚物的部分或全部酸酐基团反应制备的。即使在高温条件下，它们也不会因挥发、迁移或萃取而从聚合物中流失，可用作稳定其他聚合物的浓缩物。
• Polymer bound antioxidant stabilizers
  申请人：ATOCHEM NORTH AMERICA, INC.

  公开号：EP0306729A1

  公开（公告）日：1989-03-15

  Polymer bound antioxidants in which the antioxidant stabilizer groups are chemically bound to polymers or copolymers by an acylaminoimide or diacylhydrazide function are prepared by reacting hydrazido substituted anti­oxidants with some or all of the anhydride groups of anhydride containing polymers or copolymers to form a polymer with recurring units selected from the formulas or both wherein the units occur, e.g., in the polymer backbone, x is 0 or 1, R¹ and R² are, e.g., hydrogen and G is, e.g., wherein R³ is t-alkyl of 4-8 carbons, R⁴ is, e.g., hydrogen and X¹ is, e.g., -N(R)-C(=O)-(CH₂)b- wherein R is e.g., hydrogen and b is 0, 1 or 2. The concentration of the stabilizers bound to the polymer may be readily varied depending upon the particular end-­use of said polymer. Polymer with high concentrations of bound antioxidants can be used as masterbatches to stabilize other polymer systems.

  聚合物结合型抗氧化剂（其中抗氧化剂稳定剂基团通过酰氨基亚胺或二酰肼官能团与聚合物或共聚物化学结合）的制备方法是：将肼基取代的抗氧化剂与含酸酐聚合物或共聚物的部分或全部酸酐基团反应，形成具有选自下列公式的重复单元的聚合物： 1. 或两者，其中单元出现在聚合物骨架中，x 为 0 或 1，R¹ 和 R² 为氢，G 为....................、 其中 R³ 是含 4-8 个碳原子的 t-烷基、 R⁴是，例如，氢和 X¹ 例如是-N(R)-C(=O)-(CH₂)b-。 其中 R 是氢和 b 是 0、1 或 2。 与聚合物结合的稳定剂浓度可根据所述聚合物的特定最终用途随时改变。具有高浓度结合抗氧化剂的聚合物可用作母料来稳定其他聚合物体系。
• Dianhydride coupled polymer stabilizers
  申请人：ATOCHEM NORTH AMERICA, INC.

  公开号：EP0308886A2

  公开（公告）日：1989-03-29

  There are provided polymer stabilizers having the formula wherein A is an organic tetravalent radical of 2 to 48 carbons, D is a divalent radical -C(=O)-N(G)-C(=O)-(CH₂)x-, where x is 0 or 1, E is a monovalent radical -(CH₂)x-C(=O)NH-G, where x is 0 or 1, d is 0, 1 or 2 and G is the residue of a stabilizer group, e.g., a hydrazido-substituted hindered phenol or a hydrazido-­substituted hindered amine light stabilizers The polymer stabilizers are prepared by the reaction of hydrazido-substituted or certain amino-substituted polymer stabilizers and cyclic dianhydrides. The polymer stabilizers of the invention are useful for protecting a large variety of synthetic polymeric organic materials from the degradative effects of heat, light and oxygen. Some of the modifiers are flame retardants and many more metal deactivators in addition to their primary activity.

  聚合物稳定剂的结构式为 其中 A 是 2 至 48 个碳原子的有机四价基、 D 是二价基-C(=O)-N(G)-C(=O)-(CH₂)x-，其中 x 为 0 或 1、 E 是单价基-(CH₂)x-C(=O)NH-G，其中 x 为 0 或 1、 d 是 0、1 或 2，以及 G 是稳定剂基团的残基，如肼基取代的受阻酚或肼基取代的受阻胺光稳定剂。 通过肼基取代或某些氨基取代的聚合物稳定剂与环状二酐反应制备聚合物稳定剂。本发明的聚合物稳定剂可用于保护各种合成高分子有机材料免受热、光和氧的降解作用。其中一些改性剂是阻燃剂，而更多的改性剂除了其主要活性外，还是金属失活剂。
• Hindered phenolic N-(amido)-imides
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0443540A1

  公开（公告）日：1991-08-28

  Phenolic N-(amido)imides are provided which are useful as antioxidant stabilizers for organic materials, including a large variety of synthetic polymers, typically subject to thermooxidative degradation. The antioxidant effectiveness of the phenolic N-(amido)imide stabilizers is enhanced by the deactivating potential of the amido-imide moiety towards metals or metal ions that frequently contaminate polymer compositions and serve to catalyze thermal degradation.

  本发明提供的酚类 N-（氨基）酰亚胺可用作有机材料的抗氧化稳定剂，其中包括各种通常会发生热氧化降解的合成聚合物。酚类 N-（氨基）酰亚胺稳定剂的抗氧化效果因氨基-酰亚胺分子对金属或金属离子的失活潜能而得到增强，这些金属或金属离子经常污染聚合物成分并催化热降解。