[(2-bromo-3-thienyl)methoxy](tert-butyl)dimethylsilane | 721969-05-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: [(2-bromo-3-thienyl)methoxy](tert-butyl)dimethylsilane
• 英文别名: 2-bromo-3-(tert-butyldimethylsiloxymethyl) thiophene；2-bromo-3-(tert-butyldimethylsiloxymethyl)-thiophene；2-bromo-3-(tert-butyldimethylsiloxymethyl)thiophene；(2-Bromothiophen-3-yl)methoxy-tert-butyl-dimethylsilane
• CAS: 721969-05-7
• 化学式: C₁₁H₁₉BrOSSi
• 分子量: 307.327
• InChiKey: CRQVLYZZGJJVFW-UHFFFAOYSA-N

物化性质

• 沸点：
  296.0±25.0 °C(Predicted)
• 密度：
  1.216±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.03
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  37.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(2-bromo-3-thienyl)methoxy](tert-butyl)dimethylsilane 在 哌啶 、 四(三苯基膦)钯 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 氯仿 、 甲苯 为溶剂， 反应 136.0h， 生成 3-(4-((tert-butyldimethylsilyloxy)methyl)-5-(4-(diphenylamino)phenyl)thiophen-2-yl)-2-cyanoacrylic acid
  参考文献：
  名称：

  Organic sensitizers bearing a trialkylsilyl ether group for liquid dye sensitized solar cells

  摘要：

  In this work we present the synthesis, optical characterization and performance of five metal-free sensitizers for dye-sensitized solar cells (DSSC). All dyes include, for the first time, a trialkylsilyl ether group in the pi-conjugated bridge (a thiophene ring). The influence of different donor unities, like triarylamine (TPA), 4H-pyranylidene and dithiafulvene has been evaluated in DSSC with a liquid I-3/I- electrolyte, obtaining the best results with the 4H-pyranylidene moiety. The size and the position of the bulky group have a great importance in the efficiency of the final devices.In order to explain the recombination processes and electron life-time, charge extraction (CE) and transient photovoltage (TPV) experiments have been carried out. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2015.07.026
• 作为产物：
  描述：

  (2-溴-3-噻吩)甲醇 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 22.0h， 以70%的产率得到[(2-bromo-3-thienyl)methoxy](tert-butyl)dimethylsilane
  参考文献：
  名称：

  [EN] NONLINEAR OPTICAL COMPOUNDS AND METHODS FOR THEIR PREPARATION
  [FR] COMPOSES OPTIQUES NON LINEAIRES ET PROCEDES DE FABRICATION

  摘要：

  非线性光学活性化合物，制备非线性光学活性化合物的方法，用于制备非线性光学活性化合物的化合物，制备用于制备非线性光学活性化合物的化合物的方法，包括非线性光学活性组分的宏观结构，以及包括非线性光学活性化合物和宏观结构的器件。

  公开号：

  WO2004065384A1

文献信息

• [EN] HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME<br/>[FR] COMPOSÉS HÉTÉROARYLE UTILES EN TANT QU'INHIBITEURS DE L'ENZYME D'ACTIVATION SUMO
  申请人：DUFFEY MATTHEW O

  公开号：WO2016004136A1

  公开（公告）日：2016-01-07

  Disclosed are chemical entities which are compounds of formula (I); or pharmaceutically acceptable salts thereof; wherein Y, Ra, Ra', Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.

  公开了公式(I)的化合物或其药物可接受的盐； 其中Y、Ra、Ra'、Rb、Rc、X1、X2、X3、Rd、Z1和Z2具有本文所述的值，并且星号位置表示的立体化学配置指示绝对立体化学。 根据本公开的化学实体可用作Sumo激活酶（SAE）的抑制剂。 进一步提供了包含本公开化合物的药物组合物以及使用该组合物治疗增殖性、炎症性、心血管和神经退行性疾病或病症的方法。
• [EN] NONLINEAR OPTICAL COMPOUNDS AND METHODS FOR THEIR PREPARATION<br/>[FR] COMPOSES OPTIQUES NON LINEAIRES ET PROCEDES DE FABRICATION
  申请人：UNIV WASHINGTON

  公开号：WO2004065384A1

  公开（公告）日：2004-08-05

  Nonlinear optically active compounds, methods for making nonlinear optically active compounds, compounds useful for making nonlinear optically active compounds, methods for making compounds useful for making nonlinear optically active compounds, macrostructures tha tinclude nonlinear optically active components, and devices including the nonlinear optically active compounds and the macrostructures.

  非线性光学活性化合物，制备非线性光学活性化合物的方法，用于制备非线性光学活性化合物的化合物，制备用于制备非线性光学活性化合物的化合物的方法，包括非线性光学活性组分的宏观结构，以及包括非线性光学活性化合物和宏观结构的器件。
• Organic sensitizers bearing a trialkylsilyl ether group for liquid dye sensitized solar cells
  作者：Raquel Pérez-Tejada、Natalia Martínez de Baroja、Santiago Franco、Laia Pellejà、Jesús Orduna、Raquel Andreu、Javier Garín

  DOI：10.1016/j.dyepig.2015.07.026

  日期：2015.12

  In this work we present the synthesis, optical characterization and performance of five metal-free sensitizers for dye-sensitized solar cells (DSSC). All dyes include, for the first time, a trialkylsilyl ether group in the pi-conjugated bridge (a thiophene ring). The influence of different donor unities, like triarylamine (TPA), 4H-pyranylidene and dithiafulvene has been evaluated in DSSC with a liquid I-3/I- electrolyte, obtaining the best results with the 4H-pyranylidene moiety. The size and the position of the bulky group have a great importance in the efficiency of the final devices.In order to explain the recombination processes and electron life-time, charge extraction (CE) and transient photovoltage (TPV) experiments have been carried out. (C) 2015 Elsevier Ltd. All rights reserved.