ethyl (R)-1-(1-(4-fluorophenyl)ethyl)-1H-imidazole-5-carboxylate | 112421-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl (R)-1-(1-(4-fluorophenyl)ethyl)-1H-imidazole-5-carboxylate
• 英文别名: Flutomidate, (R)-；ethyl 3-[(1R)-1-(4-fluorophenyl)ethyl]imidazole-4-carboxylate
• CAS: 112421-36-0
• 化学式: C₁₄H₁₅FN₂O₂
• 分子量: 262.284
• InChiKey: PTPSMJOSZBOCNF-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS FOR TREATING DISORDERS ASSOCIATED WITH ABNORMAL STEROIDOGENESIS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À UNE STÉROÏDOGÈNÈSE ANORMALE
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2019067021A1

  公开（公告）日：2019-04-04

  The present application provides compounds useful for treating disorders associated with abnormal steroidogenesis. Methods of treating disorders associated with abnormal steroidogenesis, methods of inhibiting 11β-hydroxylase activity, and pharmaceutical compositions comprising the compounds are also provided.

  本申请提供了可用于治疗与异常类固醇生成相关的疾病的化合物。还提供了治疗与异常类固醇生成相关的疾病的方法，抑制11β-羟化酶活性的方法以及包含这些化合物的药物组合物。
• Compounds for Treating Disorders Associated with Abnormal Steroidogenesis
  申请人：The General Hospital Corporation

  公开号：US20200277264A1

  公开（公告）日：2020-09-03

  The present application provides compounds useful for treating disorders associated with abnormal steroidogenesis. Methods of treating disorders associated with abnormal steroidogenesis, methods of inhibiting 11β-hydroxylase activity, and pharmaceutical compositions comprising the compounds are also provided.