1-(4-(4-bromophenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine | 324066-14-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(4-(4-bromophenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine
• 英文别名: EMAC2098；4-(4-bromophenyl)-N-(cyclohexylideneamino)-1,3-thiazol-2-amine
• CAS: 324066-14-0
• 化学式: C₁₅H₁₆BrN₃S
• 分子量: 350.282
• InChiKey: KPUQBDCDOIKXJK-UHFFFAOYSA-N

物化性质

• 熔点：
  187-188 °C (decomp)(Solvent: Chloroform)
• 沸点：
  488.7±37.0 °C(predicted)
• 密度：
  1.52±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (环己亚基氨基)硫脲 在 1-(4-bromophenyl)-2-haloethan-1-one 作用下， 以 水 为溶剂， 反应 32.0h， 以79%的产率得到1-(4-(4-bromophenyl)thiazol-2-yl)-2-cyclohexylidenehydrazine
  参考文献：
  名称：

  Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida

  摘要：

  Cyclohexyliden- and 2-methylcyclohexyliden-hydrazo-4-arylthiazoles were synthesized and tested as antifungal agents. All compounds exhibited minimal inhibitory concentration (MIC) values comparable with those of fluconazole (FLC). Moreover, some compounds showed fungicidal activity at low concentration. Worth noting five out of nine compounds were active towards Candida albicans 25 FLC resistant isolated from clinical specimens. The cellular toxicity was evaluated and none of the compounds is toxic at the MIC. On the basis of our data we can conclude that these derivatives are promising agents for the treatment of resistant C. albicans.

  DOI：

  10.3109/14756366.2015.1113171

文献信息

• Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring
  作者：S.K. Bharti、G. Nath、R. Tilak、S.K. Singh

  DOI：10.1016/j.ejmech.2009.11.008

  日期：2010.2

  antimicrobial activities. The structures of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analyses. Both the anti-bacterial and anti-fungal activities with MIC values of compounds were evaluated. The results of anti-bacterial screening reveal that among all the compounds screened eight compounds showed moderate to good anti-bacterial activity while ten

  一系列的亚芳基-2-（4-（4-（4-甲氧基/溴苯基）噻唑-2-基）肼（4a – z）和1-（4-（4-甲氧基/溴苯基）噻唑-2-基）-2合成了-cyclohexydenne / cyclopentylidene肼（5a – b / 6a – b），并对其抗菌性能进行了表征和筛选。通过光谱（FT-IR，1 H NMR，1313 C NMR，质量）和元素分析。用化合物的MIC值评估了抗菌和抗真菌活性。抗菌筛选结果表明，在筛选出的所有化合物中，有八种化合物表现出中等至良好的抗菌活性，而新合成的化合物中有十种表现出良好至优异的抗真菌活性。在测试的化合物中，MIC值在6.25–25μg/ ml范围内的最有效化合物是针对三种真菌菌株viz的4a，4n，4z，5a，5b，6a和6b。白色念珠菌，新型隐球菌和黄曲霉。
• 脂环酮腙噻唑衍生物作为酪氨酸酶抑制剂的应用
  申请人：邵阳学院

  公开号：CN108409683A

  公开（公告）日：2018-08-17

  本发明公开了一种具有酪氨酸酶抑制活性的脂环酮腙噻唑类衍生物。体外抑制酪氨酸酶的筛选结果表明：所合成的脂环酮腙噻唑类衍生物部分具有酪氨酸酶抑制活性。本发明所涉及的化合物制备简单，在药物、化妆品、食品保鲜及生物杀虫剂领域具有一定的应用前景。所述脂环酮腙噻唑衍生物的化学结构式如下述结构所示，其中n与R由说明书所定义。式(Ⅰ)。
• Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida
  作者：Rita Meleddu、Simona Distinto、Angela Corona、Elias Maccioni、Antonella Arridu、Claudia Melis、Giulia Bianco、Peter Matyus、Filippo Cottiglia、Adriana Sanna、Alessandro De Logu

  DOI：10.3109/14756366.2015.1113171

  日期：2016.11.1

  Cyclohexyliden- and 2-methylcyclohexyliden-hydrazo-4-arylthiazoles were synthesized and tested as antifungal agents. All compounds exhibited minimal inhibitory concentration (MIC) values comparable with those of fluconazole (FLC). Moreover, some compounds showed fungicidal activity at low concentration. Worth noting five out of nine compounds were active towards Candida albicans 25 FLC resistant isolated from clinical specimens. The cellular toxicity was evaluated and none of the compounds is toxic at the MIC. On the basis of our data we can conclude that these derivatives are promising agents for the treatment of resistant C. albicans.