N,N-diethylbenzselenoamide | 72864-65-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethylbenzselenoamide
• 英文别名: N,N-diethylselenobenzamide；N,N-Diethylselenobenzamid；N,N-diethylbenzenecarboselenoamide
• CAS: 72864-65-4
• 化学式: C₁₁H₁₅NSe
• 分子量: 240.207
• InChiKey: JPRBLBHGJQVBOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.67
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-二乙基苯甲酰胺 在 草酰氯 、 LiAlHSeH 作用下， 以 乙醚 、 四氢呋喃 为溶剂， 反应 7.0h， 以68%的产率得到N,N-diethylbenzselenoamide
  参考文献：
  名称：

  从酰胺轻松合成 N,N-二烷基硒酰胺

  摘要：

  N,N-二烷基酰胺用草酰氯氯化，然后与 LiAlHSeH 反应，以中等至良好的产率得到相应的 N,N-二烷基硒酰胺。由于其空间位阻，带有庞大取代基的 N,N-二烷基酰胺没有转化为相应的硒酰胺。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:195–198, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10016

  DOI：

  10.1002/hc.10016

文献信息

• Convenient Syntheses of N,N-Dialkylselenoamides and N,N,N′,N′-Tetraalkylselenoureas by Treating Terminal<i>gem</i>-Dihaloalkanes, Chloroform, or Sodium Trichloroacetate with a Base, Elemental Selenium, and Amines
  作者：Yuji Takikawa、Minoru Yamaguchi、Tohru Sasaki、Kenji Ohnishi、Kazuaki Shimada

  DOI：10.1246/cl.1994.2105

  日期：1994.11

  Treatment of terminal gem-dihaloalkanes, chloroform, or sodium trichloroacetate with elemental selenium in the presence of NaH and an excess amount of primary or secondary amines gave selenoamides and selenoureas in modest yields.

  对终端gem-二卤烷、氯仿或三氯乙酸钠在NaH和过量的初级或次级胺存在下用元素硒处理，得到了中等产率的硒酰胺和硒脲。
• A Willgerodt–Kindler Type Selenation of Dihalomethane Derivatives, Chloroform, and Sodium Trichloroacetate by Treating with a Base, Elemental Selenium, and an Amine
  作者：Kazuaki Shimada、Minoru Yamaguchi、Tohru Sasaki、Kenji Ohnishi、Yuji Takikawa

  DOI：10.1246/bcsj.69.2235

  日期：1996.8

  Treatment of dihalomethane derivatives, chloroform, or sodium trichloroacetate with elemental selenium in the presence of NaH and an excess amount of an amine gave the corresponding selenoamides, selenoureas, and bis(selenocarbamoyl) triselenides in modest yields. These products were afforded from reactive intermediates related to “selenocarbonyl halides” and “selenophosgenoids” generated by the reaction of dichloromethanide ions and trichloromethanide ion with N-alkylated aminopolyselenide species (R2N–(Se)n−).

  处理二溴甲烷衍生物、氯仿或三氯乙酸钠与元素硒，配合氢化钠和过量胺，在适当条件下可得到相应的硒酰胺、硒脲和双（硒氨基）三硒化物，产率适中。这些产品来源于与“硒羰基卤化物”和“硒羰基氟化物”相关的活性中间体，这些中间体是二氯甲烷离子和三氯甲烷离子与N-烷基化氨基多硒化物（R2N–(Se)n−）反应生成的。
• Selenating reagent
  申请人：Gifu University

  公开号：US20040062706A1

  公开（公告）日：2004-04-01

  A selenating reagent obtained by reacting lithium aluminum hydride with selenium powder in an organic solvent.

  一种通过在有机溶剂中反应锂铝氢化物和硒粉获得的硒化试剂。
• Lithium aluminum hydride-based selenating reagent and preparation methods using same
  申请人：Gifu University

  公开号：US07033564B2

  公开（公告）日：2006-04-25

  A selenating reagent obtained by reacting lithium aluminum hydride with selenium powder in an organic solvent. In addition, a method for preparing a selenating reagent includes reacting lithium aluminum hydride with selenium powder in an organic solvent. Also, a method of preparing a selenium-containing product includes reacting the selenating reagent, prepared as stated, with at least one second compound which may be acyl chloride.

  一种通过在有机溶剂中将锂铝氢化物与硒粉反应而得到的硒化试剂。此外，制备硒化试剂的方法包括在有机溶剂中将锂铝氢化物与硒粉反应。还有一种制备含硒产物的方法，包括将制备好的硒化试剂与至少一种第二化合物（可能为酰氯）反应。
• Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro
  作者：Hitoe Takahashi、Atsuyoshi Nishina、Hirokazu Kimura、Kenji Motoki、Mamoru Koketsu、Hideharu Ishihara

  DOI：10.1016/j.ejps.2004.04.011

  日期：2004.11

  We investigated the scavenging effects of tertiary selenoamide compounds for super oxide radicals using a highly sensitive and quantitative chemiluminescence method. At 333 nM, tertiary selenoamide compounds scavenged 25.8-81.6% of O-2(-.).N-(Phenylselenocarbonyl) piperidine was the most effective scavenger of superoxide radicals. While N,N-diethyl-2-selenonaphthylamide and N,N-diethyl-4-chloroselenobenzamide was a moderately effective scavenger of superoxide radicals. The IC50 of N-(phenylselenocarbonyl) piperidine and N,N-diethyl-2-selenonaphthylamide were determined to be 110 and 182 nM, respectively. The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals. (C) 2004 Elsevier B.V. All rights reserved.