nudol diacetate | 86630-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: nudol diacetate
• 英文别名: (7-Acetyloxy-5,6-dimethoxyphenanthren-2-yl) acetate
• CAS: 86630-45-7
• 化学式: C₂₀H₁₈O₆
• 分子量: 354.359
• InChiKey: GHHUDYYOWZLABL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  nudol diacetate 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 3,4-二甲氧基-2,7-菲二醇
  参考文献：
  名称：

  Nudol, a phenanthrene of the orchids Eulophia nuda, Eria carinata and Eria stricta

  摘要：

  DOI：

  10.1016/s0031-9422(00)84898-0
• 作为产物：
  描述：

  3,4-二甲氧基-2,7-菲二醇 生成 nudol diacetate
  参考文献：
  名称：

  MAJUMDER, P. L.;BANERJEE, (NEE BHATTACHARYYA) SUBHRA, INDIAN J. CHEM. B, 28,(1989) N2, C. 1085-1088

  摘要：

  DOI：

文献信息

• TOLL LIKE RECEPTOR (TLR) SIGNALING ANTAGONIST
  申请人：Upadhyay Shakti

  公开号：US20090215908A1

  公开（公告）日：2009-08-27

  The present invention relates to novel synthetic toll like receptor antagonist. The present invention in particular provides compounds, methods and compositions for specifically inhibiting immune stimulation involving TLR ligands, especially TLR-4. The compounds are potentially useful in treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

  本发明涉及新型合成的Toll样受体拮抗剂。本发明特别提供了一种针对TLR配体特异性抑制免疫刺激的化合物、方法和组合物，尤其是针对TLR-4。这些化合物在治疗炎症、自身免疫、过敏、哮喘、移植排斥、移植物抗宿主病、感染、败血症、癌症和免疫缺陷方面具有潜在的用途。
• Anti-inflammatory constituents of topically applied crude drugs. III. Constituents and anti-inflammatory effect of paraguayan crude drug "tamanda cuna" (Catasetum barbatum Lindle).
  作者：MINEO SHIMIZU、HISASHI SHOGAWA、TOSHIMITSU HAYASHI、MUNEHISA ARISAWA、SHOICHI SUZUKI、MASAO YOSHIZAKI、NAOKATA MORITA、ESTIBAN FERRO、ISABEL BASUALDO、Luis H. BERGANZA

  DOI：10.1248/cpb.36.4447

  日期：——

  The 70% EtOH extract of the aerial parts of Catasetum barbatum LINDLE showed inhibitory effects on carrageenin-induced paw edema when topically applied to rats and on histamine-induced contraction in guinea pig ileum. Four compounds including a new phenanthrene, 2, 7-dihydroxy-3, 4, 8-trimethoxyphenanthrene (2), were isolated from the active fraction. 2, 7-Dihydroxy-3, 4-dimethoxyphenanthrene (1) showed inhibitory effects in both biological assays.

  当对大鼠进行局部涂抹时，Catasetum barbatum LINDLE的地上部分70%乙醇提取物对角叉菜胶诱导的足肿胀和豚鼠回肠组织胺诱导的收缩具有抑制作用。从活性部分分离出四种化合物，包括一种新的菲，2,7-二羟基-3,4,8-三甲氧基菲（2）。2,7-二羟基-3,4-二甲氧基菲（1）在两种生物测定中均显示出抑制作用。
• SHIMIZU, MINEO;SHOGAWA, HISASHI;HAYASHI, TOSHIMITSU;ARISAWA, MUNEHISA;SUZ+, CHEM. AND PHARM. BULL., 36,(1988) N1, C. 4447-4452
  作者：SHIMIZU, MINEO、SHOGAWA, HISASHI、HAYASHI, TOSHIMITSU、ARISAWA, MUNEHISA、SUZ+

  DOI：——

  日期：——
• MAJUMDER, P. L.;BANERJEE, (NEE BHATTACHARYYA) SUBHRA, INDIAN J. CHEM. B, 28,(1989) N2, C. 1085-1088
  作者：MAJUMDER, P. L.、BANERJEE, (NEE BHATTACHARYYA) SUBHRA

  DOI：——

  日期：——
• [EN] TOLL LIKE RECEPTOR (TLR) SIGNALING ANTAGONIST<br/>[FR] ANATAGONISTE DE SIGNALISATION DE RÉCEPTEURS DE TYPE TOLL (TLR)
  申请人：RELIANCE LIFE SCIENCES PVT LTD

  公开号：WO2009047791A2

  公开（公告）日：2009-04-16

  The present invention relates to novel synthetic toll like receptor antagonist. The present invention in particular provides compounds, methods and compositions for specifically inhibiting immune stimulation involving TLR ligands, especially TLR-4. The compounds are potentially useful in treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.