2-氟丁酸乙酯 | 327-46-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-氟丁酸乙酯
• 英文名称: 2-fluoro-butyric acid ethyl ester
• 英文别名: 2-Fluor-buttersaeure-aethylester；ethyl 2-fluorobutyrate；Ethyl 2-fluorobutanoate
• CAS: 327-46-8
• 化学式: C₆H₁₁FO₂
• 分子量: 134.151
• InChiKey: ONLLXDPBECIJCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  2-氟丁酸乙酯 在 盐酸 作用下， 生成 2-氟丁酸
  参考文献：
  名称：

  Bockemueller, Justus Liebigs Annalen der Chemie, 1933, vol. 506, p. 33,54

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴丁酸乙酯 在 potassium fluoride 、 十六烷基三丁基溴化磷 作用下， 反应 0.75h， 以89%的产率得到2-氟丁酸乙酯
  参考文献：
  名称：

  A semi-molten mixture of hexadecyltributylphosphonium bromide and potassium fluoride in the synthesis of organofluorine compounds

  摘要：

  A facile and effective reagent system comprising of a semi-molten mixture of hexadecyltributylphosphonium bromide and potassium fluoride has been developed and its scope has been investigated in nucleophilic fluoride exchange with various organohalides. This simple and convenient reagent system provides organofluorine compounds in high yields even with haloesters in which fluoride catalysed elimination is also feasible. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00121-9

文献信息

• Herbicidal indanylalkylamino-1,3,5-triazines, process for their preparation, compositions thereof, and their use as herbicides and plant growth regulators
  申请人：Bayer CropScience GmbH

  公开号：EP1361219A1

  公开（公告）日：2003-11-12

  The invention relates to indanylalkylamino-1,3,5-triazine derivative of formula (I) or a salt thereof: wherein the various symbols are as defined in claim 1, process for their preparation, compositions thereof, and their use as herbicides or plant growth regulators.

  本发明涉及式(I)的indanylalkylamino-1,3,5-三嗪衍生物或其盐： 其中各符号的定义如权利要求书1所述，以及其制备方法、组合物以及其作为除草剂或植物生长调节剂的用途。
• NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND
  申请人：Suzuki Keiko

  公开号：US20120108639A1

  公开（公告）日：2012-05-03

  The present invention provides a compound having excellent regulating action on blood lipid level that is represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein, in one embodiment, A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; R 1 represents COOH; each R 2 represents an alkyl; each R 3 represents an optionally substituted phenyl, an optionally substituted phenylalkyl; m represents 0, 1, 2, or 3; n represents 0 or 1; each of R 4 , R 5 , R 6 , and R 7 represents H, an alkyl; and B represents an optionally substituted naphthyl, an optionally substituted aromatic heterocyclyl, or a group represented by the following formula (II) wherein each of B 1 and B 2 represents an optionally substituted phenyl or an optionally substituted aromatic heterocyclyl.

  本发明提供了一种具有优异的调节血脂水平作用的化合物，其表示为以下通式(I)或其药学上可接受的盐，其中，在一种实施例中，A代表5-成员含氮芳香杂环基；R1代表COOH；每个R2代表烷基；每个R3代表可选取代的苯基，可选取代的苯基烷基；m代表0、1、2或3；n代表0或1；每个R4、R5、R6和R7代表H，烷基；B代表可选取代的萘基，可选取代的芳香杂环基，或由以下公式(II)表示的基团，其中，每个B1和B2代表可选取代的苯基或可选取代的芳香杂环基。
• IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS
  申请人：Eastwood Paul Robert

  公开号：US20130216498A1

  公开（公告）日：2013-08-22

  New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

  本发明揭示了具有化学式（I）的新咪唑吡啶衍生物，以及它们的制备方法，包括它们的药物组合物和它们作为Janus激酶（JAK）抑制剂在治疗中的用途。
• Fluorination with aminosulfur trifluorides
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0905109A1

  公开（公告）日：1999-03-31

  A fluorination method of oxygen and halogen sites with diaryl-, dialkoxyalkyl-, alkylalkoxyalkyl-, arylalkoxyalkyl- and cyclic aminosulfur trifluorides fluorinating reagents is disclosed.

  本发明公开了一种用二芳基、二烷氧基烷基、烷基烷氧基烷基、芳基烷氧基烷基和环状三氟化硫胺氟化试剂对氧和卤素位点进行氟化的方法。
• Bockemueller, Justus Liebigs Annalen der Chemie, 1933, vol. 506, p. 33,54
  作者：Bockemueller

  DOI：——

  日期：——