2-(3-nitrophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole | 117456-94-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3-nitrophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole
• 英文别名: 4,5-bis(4-methoxyphenyl)-2-(3-nitrophenyl)-1H-imidazole；1H-Imidazole, 4,5-bis(4-methoxyphenyl)-2-(3-nitrophenyl)-
• CAS: 117456-94-7
• 化学式: C₂₃H₁₉N₃O₄
• 分子量: 401.422
• InChiKey: JEOFWOHTZYDLKM-UHFFFAOYSA-N

物化性质

• 沸点：
  620.2±55.0 °C(Predicted)
• 密度：
  1.267±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4,5-bis(4-methoxyphenyl)-2-(3-nitrophenyl)-1H-imidazole-ethyl acetate (1/0.33) 79.85 ℃ 、266.64 Pa 条件下， 反应 6.0h， 生成 2-(3-nitrophenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole
  参考文献：
  名称：

  An ethyl acetate inclusion complex of 4,5-bis(4-methoxyphenyl)-2-(3-nitrophenyl)-1H-imidazole

  摘要：

  The host molecules of the yellow title compound, 4,5-bis(4-methoxyphenyl)-2-(3-nitrophenyl)-1H-imidazole-ethyl acetate (1/0.33), C23H19N3O4. 1/3C(4)H(8)O(2), (1), are arranged in a cross fashion through intermolecular hydrogen bonding between the N-H and N=C moieties of the imidazole ring. The ethyl acetate guest molecules are arranged in columns along the c axis. By heating under reduced pressure, (1) lost the guest molecules to become the non-solvated analogue, C23H19N3O4, without destruction of the network of host molecules.

  DOI：

  10.1107/s0108270199011087

文献信息

• Zinc (II) [tetra(4-methylphenyl)] Porphyrin: a Novel and Reusable Catalyst for Efficient Synthesis of 2,4,5-trisubstituted Imidazoles Under Ultrasound Irradiation
  作者：Javad Safari、Shiva Dehghan Khalili、Sayed Hossein Banitaba、Hossein Dehghani

  DOI：10.5012/jkcs.2011.55.5.787

  日期：2011.10.20

  An efficient three-component one-step synthesis of 2,4,5-trisubstituted imidazoles by condensation reaction of 1,2-diketones or α-hydroxyketones with aromatic aldehydes and ammonium acetate using Zinc (II) (tetra (4-methylphenyl)) porphyrin as a novel and reusable catalyst under ultrasound irradiation at ambient temperature is described. In this method, α-hydroxyketones as well as 1,2-diketones were

  使用锌（II）（四（4-甲基苯基））使1,2-二酮或α-羟基酮与芳族醛和乙酸铵缩合反应，可有效地三步合成2,4,5-三取代的咪唑描述了在室温下超声辐射下卟啉作为新型可重复使用的催化剂。在这种方法中，α-羟基酮以及1,2-二酮以优异的产率转化为它们相应的2,4,5-三取代的咪唑。
• Quinolinone derivatives
  申请人：Renhowe A. Paul

  公开号：US20050209456A1

  公开（公告）日：2005-09-22

  A method for synthesizing a 4-amino substituted quinolinone includes reacting a substituted or unsubstituted 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile in the presence of a base or an acid. A 4-amino substituted quinolinone compound is formed by the reaction, and the 4-amino substituted quinolinone compound comprises a benzimidazole group.

  一种合成4-氨基取代喹啉酮的方法，包括在碱或酸的存在下，将取代或未取代的2-苯并咪唑-2-乙酸酯与取代或未取代的2-氨基苯甲腈反应。反应生成4-氨基取代喹啉酮化合物，并且该4-氨基取代喹啉酮化合物包含苯并咪唑基团。
• FUEL FOR FUEL CELL, FUEL CELL AND APPLICATION THEREOF
  申请人：Kurita Water Industries Ltd.

  公开号：EP1705740A1

  公开（公告）日：2006-09-27

  A fuel cell fuel contains an organic fuel used as a fuel for a fuel cell. The organic fuel is in a form of a solid molecular compound, such as an inclusion compound. The molecular compound can be prepared by contact catalytic reaction of a compound for forming the molecular compound and the organic fuel, and allows a liquid organic fuel to be in a solid compound to store the organic fuel stably in a relatively lightweight form. The molecular compound easily releases the organic fuel by, for example, heating, and the organic fuel is supplied to the fuel electrode of a fuel cell. Thus, the handleability of the fuel cell fuel containing the organic fuel can be improved, and the problems of corrosion, freezing of the fuel, crossover, and so forth can be solved.

  燃料电池燃料包含一种用作燃料电池燃料的有机燃料。有机燃料以固体分子化合物的形式存在，例如包合物。该分子化合物可通过一种化合物的接触催化反应制备，该化合物用于形成分子化合物和有机燃料，可将液态有机燃料置于固体化合物中，从而以相对较轻的形式稳定地储存有机燃料。通过加热等方式，分子化合物很容易释放出有机燃料，然后将有机燃料供应给燃料电池的燃料电极。这样，含有有机燃料的燃料电池燃料的可操作性就能得到改善，腐蚀、燃料冻结、交叉等问题也能得到解决。
• A highly efficient magnetic solid acid catalyst for synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation
  作者：Javad Safari、Zohre Zarnegar

  DOI：10.1016/j.ultsonch.2012.10.004

  日期：2013.3

  Fe3O4 nanoparticles were prepared by chemical coprecipitation method and subsequently coated with 3-aminopropyltriethoxysilane (APTES) via silanization reaction. Grafting of chlorosulfuric acid on the amino-functionalized Fe3O4 nanoparticles afforded sulfamic acid-functionalized magnetic nanoparticles (SA-MNPs). SA-MNPs was found to be a mild and effective solid acid catalyst for the efficient, one-pot, three-component synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation. This protocol afforded corresponding imidazoles in shorter reaction durations, and in high yields. This green procedure has many obvious advantages compared to those reported in the previous literatures, including avoiding the use of harmful catalysts, easy and quick isolation of the products, excellent yields, short routine, and simplicity of the methodology. (C) 2012 Elsevier B.V. All rights reserved.
• IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS
  申请人：Axxima Pharmaceuticals Aktiengesellschaft

  公开号：EP1532118A2

  公开（公告）日：2005-05-25