N-methyl-4-(furan-2-yl)thiazol-2-amine | 1251197-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-methyl-4-(furan-2-yl)thiazol-2-amine
• 英文别名: 4-(furan-2-yl)-N-methyl-1,3-thiazol-2-amine
• CAS: 1251197-26-8
• 化学式: C₈H₈N₂OS
• mdl: MFCD17257352
• 分子量: 180.23
• InChiKey: RKAIOFPEAYHJJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  66.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-乙酰基呋喃 在 potassium carbonate 、 copper(I) bromide 作用下， 以 乙酸乙酯 为溶剂， 反应 5.0h， 生成 N-methyl-4-(furan-2-yl)thiazol-2-amine
  参考文献：
  名称：

  Facile One-Pot Procedure for the Synthesis of 2-Aminothiazole Derivatives

  摘要：

  A facile, efficient synthesis of 2-aminothiazole derivatives by the reaction of easily available aromatic methyl ketones with thiourea/N-substituted thioureas in the presence of copper(II) bromide was developed. The reaction underwent a one-pot alpha-bromination/cyclization process.

  DOI：

  10.3987/com-12-12510

文献信息

• Substituted 2-aminothiazoles for treating neurodegenerative diseases
  申请人：Cole Andrew G.

  公开号：US20090005568A1

  公开（公告）日：2009-01-01

  The invention relates to substituted 2-aminothiazole derivatives useful in treating disorders that are mediated by A 2a receptor function, including neurodegenerative diseases including Parkinson's disease and inflammation. The compounds have general formula I:

  该发明涉及到用于治疗由A2a受体功能介导的疾病的取代2-氨基噻唑衍生物，包括神经退行性疾病，如帕金森病和炎症。这些化合物具有一般公式I：
• Facile One-Pot Procedure for the Synthesis of 2-Aminothiazole Derivatives
  作者：Guodong Yin、Junrui Ma、Houqiang Shi、Qing Tao

  DOI：10.3987/com-12-12510

  日期：——

  A facile, efficient synthesis of 2-aminothiazole derivatives by the reaction of easily available aromatic methyl ketones with thiourea/N-substituted thioureas in the presence of copper(II) bromide was developed. The reaction underwent a one-pot alpha-bromination/cyclization process.