N-(2-hydroxy-propyl)-lactamide | 6281-43-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-hydroxy-propyl)-lactamide
• 英文别名: N-(2-Hydroxy-propyl)-lactamid；Milchsaeure-(2-hydroxy-propylamid)；1-Lactoylamino-propan-2-ol；N-(2-hydroxypropyl)lactic acid amide；2-Hydroxy-n-(2-hydroxypropyl)propanamide
• CAS: 6281-43-2
• 化学式: C₆H₁₃NO₃
• mdl: MFCD19218390
• 分子量: 147.174
• InChiKey: RBIYCFYMQYWICN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxy-propyl)-lactamide 、 乙酸酐 生成 1-(2-乙酰氧基丙酰氨基)丙-2-基乙酸酯
  参考文献：
  名称：

  N-Substituted Lactamides

  摘要：

  DOI：

  10.1021/ja01105a022
• 作为产物：
  描述：

  乳酸甲酯 、 异丙醇胺 生成 N-(2-hydroxy-propyl)-lactamide
  参考文献：
  名称：

  乳酸的N-羟烷基酰胺

  摘要：

  DOI：

  10.1021/ie50488a030

文献信息

• Flavour Compositions
  申请人：Kaouas Abdelmajid

  公开号：US20080199584A1

  公开（公告）日：2008-08-21

  The present invention in a first aspect relates to flavour modulation in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products, using a flavour modulating substance selected from the group of substances represented by formula (I) or formula (II), edible salts thereof and edible esters thereof: It has been found that these substances are capable imparting highly desirable taste attributes in the products they are incorporated in. In addition said flavour modulating substances are capable of modulating and complementing, the sensory impact of other, taste imparting, substances. Thus, the present substances are advantageously applied in flavour compositions, foodstuffs, pharmaceutics, tobacco products and oral care products. Typical examples of flavour modulating substances according to the present invention include 2-hydroxy-N-(2-hydroxy-2-methylpropyl)-propanamide, N-lactoyl 1-amino-2-propanol, N-lactoyl 2-amino-1-propanol, N-lactoyl 2-amino-2-methylpropanol, N-gluconyl 1-amino-2-methyl-2-propanol, N-gluconyl 1-amino-2-propanol, N-gluconyl 2-amino-1-propanol, N-gluconyl 2-amino-2-methylpropanol, N-(2-mercaptopropyl)lactamide, edible salts thereof and edible esters thereof.

  本发明在第一方面涉及食品、饮料、药品、烟草产品和口腔护理产品中的风味调节，使用从由式（I）或式（II）代表的物质组中选择的风味调节物质，其可食盐和可食酯。已经发现这些物质能够在其所包含的产品中赋予高度理想的口感属性。此外，所述风味调节物质能够调节和补充其他口感物质的感官影响。因此，这些物质优势地应用于风味组合、食品、药品、烟草产品和口腔护理产品中。根据本发明，风味调节物质的典型例子包括2-羟基-N-（2-羟基-2-甲基丙基）-丙酰胺，N-乳酰基1-氨基-2-丙醇，N-乳酰基2-氨基-1-丙醇，N-乳酰基2-氨基-2-甲基丙醇，N-葡萄糖基1-氨基-2-甲基-2-丙醇，N-葡萄糖基1-氨基-2-丙醇，N-葡萄糖基2-氨基-1-丙醇，N-葡萄糖基2-氨基-2-甲基丙醇，N-（2-巯基丙基）乳酰胺，其可食盐和可食酯。
• Flavour compositions
  申请人：Givaudan Nederland Services B.V.

  公开号：US09155329B2

  公开（公告）日：2015-10-13

  Flavor modulation in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products, using a flavor modulating substance selected from substances represented by formula (I) or formula (II), edible salts thereof and edible esters thereof: These substances are capable of imparting highly desirable taste attributes in the products in which they are incorporated. In addition the flavor modulating substances are capable of modulating and complementing the sensory impact of other taste imparting substances. The substances are applied in flavor compositions, foodstuffs, pharmaceutics, tobacco products and oral care products. Examples of flavor modulating substances include 2-hydroxy-N-(2-hydroxy-2-methylpropyl)-propanamide, N-lactoyl 1-amino-2-propanol, N-lactoyl 2-amino-1-propanol, N-lactoyl 2-amino-2-methylpropanol, N-gluconyl 1-amino-2-methyl-2-propanol, N-gluconyl 1-amino-2-propanol, N-gluconyl 2-amino-1-propanol, N-gluconyl 2-amino-2-methylpropanol, N-(2-mercaptopropyl)lactamide, edible salts thereof and edible esters thereof.

  食品、饮料、药品、烟草产品和口腔护理产品中的风味调节，使用从公式（I）或公式（II）所代表的物质中选择的风味调节物质、其可食用的盐和酯：这些物质能够在所加入的产品中赋予高度理想的口味特征。此外，风味调节物质能够调节和补充其他口味物质的感官影响。这些物质应用于风味组合物、食品、药品、烟草产品和口腔护理产品中。风味调节物质的例子包括2-羟基-N-（2-羟基-2-甲基丙基）丙酰胺、N-乳酰基1-氨基-2-丙醇、N-乳酰基2-氨基-1-丙醇、N-乳酰基2-氨基-2-甲基丙醇、N-葡萄糖基1-氨基-2-甲基-2-丙醇、N-葡萄糖基1-氨基-2-丙醇、N-葡萄糖基2-氨基-1-丙醇、N-葡萄糖基2-氨基-2-甲基丙醇、N-（2-巯基丙基）乳酰胺、其可食用的盐和酯。
• Polymer coating for medical devices
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1764118A2

  公开（公告）日：2007-03-21

  The present invention relates to a coating for a medical device having a body fluid-contacting surface for contacting blood or other body fluids, the coating comprising: a silane derivative layer covalently bonded to the body fluid-contacting surface of the medical device, said silane derivative layer containing hydroxyl or amino functional groups; a lactone polymer layer polymerized on the hydroxyl or amino functional groups of the silane derivative layer through in-situ ring opening graft polymerization of lactone monomers, said polymerization initiated by said hydroxyl or amino functional groups of the silane derivative layer; at least one polyester polymer layer comprising one or more biologically active agents deposited on the lactone polymer layer, wherein at least the first layer of the at least one polyester polymer layer is chemically compatible with the lactone polymer layer to allow for entanglement of the polyester polymer chains with the lactone polymer chains; and optionally at least one polymer layer deposited on said at least one polyester polymer layer forming a skin or barrier layer.

  本发明涉及一种用于医疗设备的涂层，该医疗设备具有用于接触血液或其他体液的体液接触表面，该涂层包括 共价键合到医疗设备体液接触表面的硅烷衍生物层，所述硅烷衍生物层含有羟基或氨基官能团； 通过内酯单体原位开环接枝聚合在硅烷衍生物层的羟基或氨基官能团上聚合的内酯聚合物层，所述聚合由硅烷衍生物层的所述羟基或氨基官能团引发； 至少一个聚酯聚合物层，包含沉积在内酯聚合物层上的一种或多种生物活性剂，其中至少一个聚酯聚合物层的至少第一层与内酯聚合物层化学相容，以允许聚酯聚合物链与内酯聚合物链缠结；以及 可选择在所述至少一层聚酯聚合物层上沉积至少一层聚合物层，形成表皮层或阻隔层。
• POLYMER COATING FOR MEDICAL DEVICES
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1492581A1

  公开（公告）日：2005-01-05
• IMPROVED FLAVOUR COMPOSITIONS
  申请人：Givaudan Nederland Services B.V.

  公开号：EP1919303B1

  公开（公告）日：2011-04-20