nonadec-1-en-4-ol | 121342-62-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: nonadec-1-en-4-ol
• 英文别名: 1-Nonadecen-4-ol
• CAS: 121342-62-9
• 化学式: C₁₉H₃₈O
• 分子量: 282.51
• InChiKey: ZLGVCQXWYKJRPY-UHFFFAOYSA-N

物化性质

• 沸点：
  376.7±11.0 °C(Predicted)
• 密度：
  0.842±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  nonadec-1-en-4-ol 在 sodium chlorite 、 sodium periodate 、 potassium dihydrogenphosphate 、 四氧化锇 、 N-甲基吲哚酮 作用下， 生成 外消旋-3-羟基十八烷酸
  参考文献：
  名称：

  Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

  摘要：

  A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our sidechain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00424-8
• 作为产物：
  描述：

  十六醛 、 烯丙基三甲基硅烷 在 四氯化钛 作用下， 以70%的产率得到nonadec-1-en-4-ol
  参考文献：
  名称：

  Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2

  摘要：

  A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our sidechain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00424-8

文献信息

• Enantioselective Syntheses of Cryptocarya Triacetate, Cryptocaryolone, and Cryptocaryolone Diacetate
  作者：Catherine M. Smith、George A. O'Doherty

  DOI：10.1021/ol0345529

  日期：2003.5.1

  products from Cryptocarya latifolia have been achieved in 13-15 steps from ethyl sorbate. The route relies upon an enantio- and regioselective Sharpless dihydroxylation and a palladium-catalyzed reduction to establish the absolute stereochemistry. The route also relies upon a highly (E)-selective olefin cross-metathesis reaction to form trans-delta-hydroxy-1-enoates. The resulting delta-hydroxy-1-enoates were

  [反应：见正文]来自山茱rypto的三种天然产物的对映选择性合成是从山梨酸乙酯经过13到15步完成的。该路线依赖于对映体和区域选择性的Sharpless二羟基化反应和钯催化的还原反应，以建立绝对的立体化学。该路线还依赖于高度（E）-选择性的烯烃交叉复分解反应以形成反式-δ-羟基-1-烯酸酯。随后将所得的δ-羟基-1-烯酸酯转化为隐乙酸三乙酸酯，隐caryolone和双隐隐caryolone。
• Methods of using hydroxy-, alkoxy- and benzyloxy-substituted
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US05145844A1

  公开（公告）日：1992-09-08

  Novel hydroxy-,alkoxy-and benzyloxy-substituted phospholipids, a process for the preparation thereof, and methods for treating pain, phospholipase A.sub.2 mediated inflammation and similar conditions utilizing compounds or compositions thereof are disclosed.

  本发明披露了新型的羟基、烷氧基和苄氧基取代的磷脂类化合物及其制备方法，以及利用这些化合物或组合物治疗疼痛、磷脂酶A2介导的炎症和类似疾病的方法。
• Hydroxy-, alkoxy- and benzyloxy-substituted phospholipids
  申请人：Hoechst-Roussel Pharmaceticals Incorporated

  公开号：US05030733A1

  公开（公告）日：1991-07-09

  Novel hydroxy-, alkoxy- and benzyloxy-substituted phospholipids, a process for the preparation thereof, and methods for treating pain, phospholipase, A.sub.2 mediated inflammation and similar conditions utilizing compounds or compositions thereof are disclosed.

  本发明揭示了新型的含羟基，烷氧基和苄氧基取代的磷脂，其制备方法，以及利用这些化合物或组合物治疗疼痛，磷脂酶A.sub.2介导的炎症和类似情况的方法。
• Hydroxy-, Alkoxy- and Benzyloxy substituted phospholipids, a process for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0300397A2

  公开（公告）日：1989-01-25

  The present invention relates to novel hydroxy-, alkoxy-­and benzyloxy-substituted phospholipids and a process for the preparation thereof. The compounds of the invention are suitable for treating phospholipase A₂ mediated inflammation conditions and can, therefore, be used as medicaments.

  本发明涉及新型羟基、烷氧基和苄氧基取代磷脂及其制备工艺。本发明的化合物适用于治疗磷脂酶 A₂介导的炎症，因此可用作药物。
• US5030733A
  申请人：——

  公开号：US5030733A

  公开（公告）日：1991-07-09