2-氨基-3-吡唑-1-丙酸 | 28024-60-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-氨基-3-吡唑-1-丙酸
• 中文别名: 2-氨基-3-(1-吡唑基)丙酸
• 英文名称: β-Pyrazol-1-yl-alanin
• 英文别名: (+/-)-2-Amino-3-propionsaeure；2-azaniumyl-3-pyrazol-1-ylpropanoate
• CAS: 28024-60-4
• 化学式: C₆H₉N₃O₂
• mdl: MFCD09832221
• 分子量: 155.156
• InChiKey: PIGOPELHGLPKLL-UHFFFAOYSA-N

物化性质

• 熔点：
  245-247 °C (decomp)
• 沸点：
  342.8±37.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933199090

反应信息

• 作为反应物：
  描述：

  2-氨基-3-吡唑-1-丙酸 生成 2-amino-3-(1H-pyrazol-1-yl)propanoic acid, tert-butyl ester
  参考文献：
  名称：

  4-Methoxy-Pyrrolidine-2-Carboxylic Acid Compounds and Derivatives Thereof as Hepatitis C Virus Inhibitors

  摘要：

  式(Ia)的抗病毒剂，其中：A代表羟基；D代表4-叔丁基-3-甲氧基苯基；E代表1,3-噻唑-2-基或5-甲基-1,3-噻唑-2-基；G代表甲氧甲基；J代表1,3-噻唑-2-基甲基，1,3-噻唑-4-基甲基，1,2-噻唑-3-基甲基或1H-吡唑-1-基甲基；以及它们的盐、溶剂化合物和酯；但当A酯化形成-OR时，其中R选择直链或支链烷基、芳基烷基、芳氧基烷基或芳基，则R不是叔丁基；提供了它们的制备方法和在HCV治疗中的应用。

  公开号：

  US20070270475A1
• 作为产物：
  描述：

  (RS)-N-acetylpyrazolylalanine potassium salt 在 盐酸 作用下， 以100%的产率得到2-氨基-3-吡唑-1-丙酸
  参考文献：
  名称：

  Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

  摘要：

  Enantiomerically pure (S)-pyrazolylalanine and its derivatives are nonproteinogenic amino acids with antidiabetic activity. A short and effective enantioselective synthesis of these compounds is described, using a kinetic resolution by an acylase from Aspergillus sp. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

  DOI：

  10.1016/s0957-4166(00)00463-8

文献信息

• Inhibitors of hepatitis C virus NS3 protease
  申请人：——

  公开号：US20020065248A1

  公开（公告）日：2002-05-30

  The present invention relates to compounds of Formula (I): 1 wherein A 1 is methylene, ethylene or propylene group and A 2 is N or CR 5 , or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HCV NS3 protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.

  本发明涉及化合物的结构公式（I）：其中A1为亚甲基、乙烯基或丙烯基，A2为N或CR5，或其立体异构体形式、立体异构体混合物或药用盐形式，用作HCV NS3蛋白酶的抑制剂，以及包含相同化合物的药物组合物和诊断试剂盒，以及用于治疗病毒感染或作为测定标准或试剂的方法。
• (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives
  申请人：——

  公开号：US20030199571A1

  公开（公告）日：2003-10-23

  Compounds of formula (I) wherein R is hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R 1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23 or TNF.

  式（I）中的化合物，其中R是氢，烷基烯基，炔基，芳基，杂芳基或杂环烷基；R1是双环烷基或杂双环烷基；在通过s-CD23或TNF介导的疾病的治疗和预防中是有用的。
• Diagnostic and therapeutic agents
  申请人：Taube Seija

  公开号：US20070258899A1

  公开（公告）日：2007-11-08

  Tumor targeting units are disclosed which have a peptide sequence C y —Y—G-F—X—W-G-Z-C yy (SEQ ID NO: 25), or a pharmaceutically or physiologically acceptable salt thereof. Tumor targeting agents are also disclosed having at least one targeting unit, directly or indirectly coupled to at least one effector unit. Diagnostic or pharmaceutical compositions having at least one targeting unit or at least one targeting agent, and targeting units or targeting agents for the preparation of a medicament for the treatment of cancer related diseases (including cancer), especially for the treatment of colon/colorectal cancer or its metastases are also disclosed.

  揭示了具有肽序列Cy—Y—G-F—X—W-G-Z-Cyy（序列ID编号：25）或其药学或生理上可接受的盐的肿瘤靶向单元。还披露了具有至少一个靶向单元的肿瘤靶向剂，直接或间接地偶联至至少一个效应单元。还披露了具有至少一个靶向单元或至少一个靶向剂的诊断或药物组合物，以及用于制备治疗癌症相关疾病（包括癌症）的药物的靶向单元或靶向剂，特别是用于治疗结肠/结直肠癌或其转移的靶向单元或靶向剂。
• Extended Dormancy of Deciduous Woody Plants treated in Autumn with Gibberellic Acid
  作者：P. W. BRIAN、J. H. P. PETTY、P. T. RICHMOND

  DOI：10.1038/184069a0

  日期：1959.7

  WEAVER1 has shown that autumnal application of gibberellin prolongs dormancy of Vitis vinifera shoots in the following spring. We2 recently reported that application of gibberellic acid in late summer and autumn delayed leaf-fall of several woody species; further observations on these plants this spring have shown that in many of them dormancy was prolonged. Thus this unexpected response to gibberellins may not be uncommon.

  WEAVER1 表明，秋季施用赤霉素可延长次年春季葡萄芽的休眠时间。 We2 最近报道，夏末和秋季施用赤霉酸延迟了几种木本植物的落叶；今年春天对这些植物的进一步观察表明，其中许多植物的休眠期延长了。因此，对赤霉素的这种意外反应可能并不罕见。
• TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY
  申请人：Gombert Frank Otto

  公开号：US20130225506A1

  公开（公告）日：2013-08-29

  Novel template-fixed β-hairpin peptidomimetics of the general formula (I), wherein the single elements T or P are α-amino acid residues connected from the carbonyl (C═O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these β-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells.

  该模板固定的β-折叠肽类似物具有一般式（I），其中单个元素T或P是α-氨基酸残基，从羰基（C═O）连接点连接到顺时针方向下一个元素的氮（N），并且这些元素根据它们在链中的位置在说明书和权利要求中定义，具有作用于CXCR7受体的特性。因此，这些β-折叠肽类似物可用于治疗或预防皮肤疾病、代谢性疾病、炎症性疾病、纤维性疾病、感染性疾病、神经系统疾病、心血管疾病、呼吸系统疾病、胃肠道疾病、泌尿系统疾病、眼科疾病、口腔疾病、血液学疾病和癌症；或干细胞的动员。