1,4-anhydro-2,3-di-O-trimethylsilyl-meso-erythritol | 929559-50-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 1,4-anhydro-2,3-di-O-trimethylsilyl-meso-erythritol
• 英文别名: trimethyl-[(3R,4S)-4-trimethylsilyloxyoxolan-3-yl]oxysilane
• CAS: 929559-50-2
• 化学式: C₁₀H₂₄O₃Si₂
• 分子量: 248.47
• InChiKey: IIQWSKSOSGANCR-AOOOYVTPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.46
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Diazo-3-oxo-butyric acid methyl ester 、 1,4-anhydro-2,3-di-O-trimethylsilyl-meso-erythritol 在 辛酸铑 作用下， 以 neat (no solvent) 为溶剂， 反应 1.0h， 生成 、
  参考文献：
  名称：

  功能丰富的聚醚大环化合物的一锅多组分合成和固态结构

  摘要：

  AbstractDensely functionalized polyether macrocycles can be prepared in one pot in yields up to 60% by the rhodium(II)‐catalyzed decomposition of methyl diazoacetoacetate in the presence of a variety of substituted or unsaturated 5‐ and 6‐membered ring cyclic ethers. A comprehensive analysis of the solid state conformations of the macrocyclic geometries is detailed as well as novel mechanistic insights about the multi‐component condensation reaction.magnified image

  DOI：

  10.1002/adsc.201300462
• 作为产物：
  描述：

  三甲基氰硅烷 、 anhydroerythritol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以95%的产率得到1,4-anhydro-2,3-di-O-trimethylsilyl-meso-erythritol
  参考文献：
  名称：

  功能丰富的聚醚大环化合物的一锅多组分合成和固态结构

  摘要：

  AbstractDensely functionalized polyether macrocycles can be prepared in one pot in yields up to 60% by the rhodium(II)‐catalyzed decomposition of methyl diazoacetoacetate in the presence of a variety of substituted or unsaturated 5‐ and 6‐membered ring cyclic ethers. A comprehensive analysis of the solid state conformations of the macrocyclic geometries is detailed as well as novel mechanistic insights about the multi‐component condensation reaction.magnified image

  DOI：

  10.1002/adsc.201300462

文献信息

• A versatile biobased continuous flow strategy for the production of 3-butene-1,2-diol and vinyl ethylene carbonate from erythritol
  作者：Nelly Ntumba Tshibalonza、Romaric Gérardy、Zouheir Alsafra、Gauthier Eppe、Jean-Christophe M. Monbaliu

  DOI：10.1039/c8gc02468e

  日期：——

  A versatile, tunable and robust continuous flow procedure for the upgrading of erythritol toward important industrial building blocks.

  一种多功能、可调节和稳健的连续流程，用于将赤藓醇升级为重要的工业基础化合物。
• One-Pot Multi-Component Synthesis and Solid State Structures of Functionally Rich Polyether Macrocycles
  作者：Mahesh Vishe、Radim Hrdina、Laure Guénée、Céline Besnard、Jérôme Lacour

  DOI：10.1002/adsc.201300462

  日期：2013.11.11

  AbstractDensely functionalized polyether macrocycles can be prepared in one pot in yields up to 60% by the rhodium(II)‐catalyzed decomposition of methyl diazoacetoacetate in the presence of a variety of substituted or unsaturated 5‐ and 6‐membered ring cyclic ethers. A comprehensive analysis of the solid state conformations of the macrocyclic geometries is detailed as well as novel mechanistic insights about the multi‐component condensation reaction.magnified image