tert-butyl N-[3-[(2-methyl-2-nitropropoxy)carbonylamino]propyl]carbamate | 609772-28-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[3-[(2-methyl-2-nitropropoxy)carbonylamino]propyl]carbamate
• CAS: 609772-28-3
• 化学式: C₁₃H₂₅N₃O₆
• 分子量: 319.358
• InChiKey: ZDFGMHURNWQTGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[3-[(2-methyl-2-nitropropoxy)carbonylamino]propyl]carbamate 在 samarium diiodide 、 溶剂黄146 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 194.0h， 生成
  参考文献：
  名称：

  Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid

  摘要：

  The synthesis of a new amphiphilic antioxidant called PBNLP and derived from both alpha-phenyl-N-tert-butyl nitrone (PBN) and lipoic acid was described. Grafting a lactobionamide moiety onto the aromatic group of the PBN provided the water solubility of this compound. In vitro preliminary biological evaluations of its antioxidant capacity were performed using the KRL biological test based on free radical-induced hemolysis. The PBNLP induces a protection of erythrocytes against exogenous free radicals higher than that measured with lipoic acid or PBN alone or with lipoic acid or PBN derivatives in admixtures. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00545-6
• 作为产物：
  描述：

  2-甲基-2-硝基-1-丙醇 、 N-BOC-GAMMA-氨基丁酸 在 叠氮磷酸二苯酯 、 三乙烯二胺 作用下， 以 甲苯 为溶剂， 生成 tert-butyl N-[3-[(2-methyl-2-nitropropoxy)carbonylamino]propyl]carbamate
  参考文献：
  名称：

  Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid

  摘要：

  The synthesis of a new amphiphilic antioxidant called PBNLP and derived from both alpha-phenyl-N-tert-butyl nitrone (PBN) and lipoic acid was described. Grafting a lactobionamide moiety onto the aromatic group of the PBN provided the water solubility of this compound. In vitro preliminary biological evaluations of its antioxidant capacity were performed using the KRL biological test based on free radical-induced hemolysis. The PBNLP induces a protection of erythrocytes against exogenous free radicals higher than that measured with lipoic acid or PBN alone or with lipoic acid or PBN derivatives in admixtures. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00545-6

文献信息

• Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid
  作者：G. Durand、A. Polidori、J.P. Salles、M. Prost、P. Durand、B. Pucci

  DOI：10.1016/s0960-894x(03)00545-6

  日期：2003.8

  The synthesis of a new amphiphilic antioxidant called PBNLP and derived from both alpha-phenyl-N-tert-butyl nitrone (PBN) and lipoic acid was described. Grafting a lactobionamide moiety onto the aromatic group of the PBN provided the water solubility of this compound. In vitro preliminary biological evaluations of its antioxidant capacity were performed using the KRL biological test based on free radical-induced hemolysis. The PBNLP induces a protection of erythrocytes against exogenous free radicals higher than that measured with lipoic acid or PBN alone or with lipoic acid or PBN derivatives in admixtures. (C) 2003 Elsevier Ltd. All rights reserved.