butyl 3-(butylamino)propanoate | 1001093-55-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: butyl 3-(butylamino)propanoate
• CAS: 1001093-55-5
• 化学式: C₁₁H₂₃NO₂
• mdl: MFCD24388468
• 分子量: 201.309
• InChiKey: SWIUCRILGXSFQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  butyl 3-(butylamino)propanoate 在 氧气 、 manganese triacetate 、 sodium butanolate 作用下， 以 溶剂黄146 为溶剂， 反应 14.0h， 生成 6-butoxycarbonyl-8-butyl-1-hydroxy-4,4-diphenyl-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one
  参考文献：
  名称：

  Nguyen, Van-Ha; Nishino, Hiroshi; Kurosawa, Kazu, Heterocycles, 1998, vol. 48, # 3, p. 465 - 480

  摘要：

  DOI：
• 作为产物：
  描述：

  丙烯酸丁酯 、 正丁胺 以 甲苯 为溶剂， 反应 20.0h， 以44%的产率得到butyl 3-(butylamino)propanoate
  参考文献：
  名称：

  使用可回收金催化剂进行活化烯烃的分子间单氢胺化和二氢胺化

  摘要：

  氯化金有机金属络合物和银盐的组合用于催化活化烯烃的分子间加氢胺化，即氮杂-迈克尔反应。研究了活化烯烃与氮底物的金催化反应，发现可以提供各种单氢胺化和二氢胺化产物，后者是罕见的和原始的。快速色谱后，金 NHC 催化剂可以作为氢氧化金 NHC 复合物回收。当与银盐结合时，金络合物再次导致活性加氢胺化催化剂。

  DOI：

  10.1002/ejoc.201200891

文献信息

• Uncatalysed intermolecular aza-Michael reactions
  作者：Florian Medina、Nathalie Duhal、Christophe Michon、Francine Agbossou-Niedercorn

  DOI：10.1016/j.crci.2012.11.001

  日期：2013.4

  Résumé The catalyst-free reactions of activated alkenes with primary and secondary amines were investigated leading to various mono- and di-hydroamination products, the latter being rare and original. These reactions were shown to depend first on the strength of the nucleophile. Temperature and steric hindrance of the reagents were the other key factors controlling the selectivity of these aza-Michael reactions. In spite of their poor nucleophilicities, some N-heterocyclic amines could react with different activated alkenes affording valuable intermediates. Such results tended to demonstrate the hydrogen-bonding interactions between activated alkenes and poly-nitrogen aromatic cycles may control these concerted or fully conjugate aza-Michael additions. Supplementary Materials: Supplementary material for this article is supplied as a separate file: mmc1.doc

  简历 摘要 研究了活性烯烃与一级和二级胺的无催化剂反应，生成多种单氢胺化和双氢胺化产物，后者较为罕见且具有原创性。这些反应首先取决于亲核试剂的强度。温度和试剂的立体阻碍是控制这些氮杂迈克尔反应选择性的其他关键因素。尽管某些含氮杂环胺的亲核性较差，但它们仍能与不同的活性烯烃反应，生成有价值的中间体。这些结果倾向于表明，活性烯烃与多氮芳香环之间的氢键相互作用可能控制这些协同或完全共轭的氮杂迈克尔加成反应。 补充材料： 本文的补充材料以单独文件提供： mmc1.doc
• Tandem bis-aza-Michael addition reaction of amines in aqueous medium promoted by polystyrenesulfonic acid
  作者：Vivek Polshettiwar、Rajender S. Varma

  DOI：10.1016/j.tetlet.2007.10.008

  日期：2007.12

  An efficient and environmentally benign tandem bis-aza-Michael addition of amines catalyzed by polystyrenesulfonic acid (PSSA) is described. This operationally simple high yielding microwave assisted synthetic protocol proceeded in water in the absence of any organic solvent. (c) 2007 Elsevier Ltd. All rights reserved.
• Horalek, Jiri; Svestka, Stefan; Krejcar, Emil, Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 12, p. 3149 - 3153
  作者：Horalek, Jiri、Svestka, Stefan、Krejcar, Emil、Novak, Jiri

  DOI：——

  日期：——
• Verfahren zur Herstellung von Azofarbstoffen
  申请人：BAYER AG

  公开号：EP0237910B1

  公开（公告）日：1990-05-30
• Sensors with improved properties
  申请人：Munoz Beth C.

  公开号：US20090260423A1

  公开（公告）日：2009-10-22

  A sensor or a sensor array connected to an electrical measuring apparatus is disclosed. In one embodiment, at least one sensor contains a layer of conductive modified particles which forms an electrical pathway or electrical circuit between two electrodes which are connected to an electrical measuring apparatus. In another embodiment, the first sensor contains at least one region of a nonconducting material and also a region that contains one or more modified particles. The modified particles are preferably conductive. An electrical path exists though the regions of the nonconducting material and the region containing the modified particles. The modified particles are conductive and more preferably are pigment particles such as modified carbon black, wherein the modified particles have attached at least one organic group. Alternatively, or in addition, the modified particle can be an aggregate having a carbon phase and a silicon-containing species phase and/or a metal-containing species phase wherein the aggregate optionally has attached at least one organic group. A sensor array for detecting an analyte in a fluid is also disclosed wherein each sensor emits a different response signature to an analyte wherein at least one of the sensors contains at least the modified particles as described above. Also, the present invention relates to a method for detecting the presence of an analyte in a fluid. The method involves contacting one or more sensors as described above with the analyte to generate a response and detecting the response with a detector that is operatively associated with each sensor in order to detect the presence of an analyte. Other advantages and embodiments are further described.