sulphadiazine | 1481855-38-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sulphadiazine
• 英文别名: 4-(Pyrimidin-2-ylmethylsulfonyl)aniline
• CAS: 1481855-38-2
• 化学式: C₁₁H₁₁N₃O₂S
• mdl: MFCD17523102
• 分子量: 249.293
• InChiKey: BENQQDYRSJKPBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  94.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-苄氧羰基-L-苯丙氨酸 、 sulphadiazine 在 吗啉 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 以70%的产率得到benzyl 1-oxo-3-phenyl-1-(4-(N-pyrimidin-2-ylsulfamoyl)phenylamino)propan-2-ylcarbamate
  参考文献：
  名称：

  Synthesis and antibacterial evaluation of amino acid–antibiotic conjugates

  摘要：

  Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5a), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened. (c) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2014.01.065

文献信息

• Synthesis and antibacterial evaluation of amino acid–antibiotic conjugates
  作者：Mohamed A. Ibrahim、Siva S. Panda、Antoinette S. Birs、Juan C. Serrano、Claudio F. Gonzalez、Khalid A. Alamry、Alan R. Katritzky

  DOI：10.1016/j.bmcl.2014.01.065

  日期：2014.4

  Amino acid conjugates of quinolone, metronidazole and sulfadiazine antibiotics were synthesized in good yields using benzotriazole methodology. All the conjugates were screened for their antibacterial activity using methods adapted from the Clinical and Laboratory Standards Institute. Antibiotic conjugates were tested for activity in four medically relevant organisms; Staphylococcus aureus (RN4220), Escherichia coli (DH5a), Pseudomonas aeruginosa (PAO1), and Bacillus subtilis (168). Several antibiotic conjugates show promising results against several of the strains screened. (c) 2014 Published by Elsevier Ltd.