Boc-Gly-NHEt | 56406-64-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Gly-NHEt
• 英文别名: N2-tert-butoxycarbonyl-N1-ethylglycinamide；(CH3)3Coc(O)nhch2C(O)nhch2CH3；tert-butyl N-[2-(ethylamino)-2-oxoethyl]carbamate
• CAS: 56406-64-5
• 化学式: C₉H₁₈N₂O₃
• 分子量: 202.254
• InChiKey: YNZCVFHYMKPLJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Boc-Gly-NHEt 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以1.6 g的产率得到2-氨基-N-乙基乙酰胺盐酸盐
  参考文献：
  名称：

  [EN] PYRAZOLOPYRIMIDINES, COMPOSITIONS COMPRISING THEM AND USES THEREOF
  [FR] PYRAZOLOPYRIMIDINES, COMPOSITIONS LES COMPRENANT ET LEURS UTILISATIONS

  摘要：

  The present document relates to pyrazolopyrimidine compounds, pharmaceutical compositions comprising the same and their use in the treatment or prevention of diseases and disorders associated with the cannabinoid CB1receptor. For example, the pyrazolopyrimidine compounds, or a tautomeric form and/or salt thereof, are of Formula I: Formula I wherein R1to R4are as defined herein.

  公开号：

  WO2023155004A1
• 作为产物：
  描述：

  BOC-甘氨酸-N-羟基琥柏酰亚胺酯 、 乙胺 以 甲醇 为溶剂， 生成 Boc-Gly-NHEt
  参考文献：
  名称：

  Direct Joining of a Heterogeneous Pair of Supramolecular Nanotubes and Reaction Control of a Guest Compound by Transportation in the Nanochannels

  摘要：

  Abstract Four novel amino-acid lipids were synthesized and then self-assembled in water to produce four different types of supramolecular nanotubes. The nanotubes consisted of a single monolayer of amino-acid lipids packed in parallel and had similar inner diameters and membrane wall thicknesses but dissimilarly charged surfaces. Mixing of nanotubes that had cationic exterior surfaces with nanotubes that had anionic exterior surfaces resulted in aggregation of the nanotubes. In contrast, mixing of nanotubes with cationic interior surfaces and nanotubes with anionic interior surfaces resulted in end-to-end joining of the two types of nanotubes via electrostatic attractions at the open ends to form heterogeneous nanotubes. Time-lapse fluorescence microscopy confirmed that a fluorophore could be transported through the heterogeneous nanotubes, which had alternating acidic and basic nanochannel segments. In addition, acid–base reactions of the fluorophore could be precisely controlled during transport. This nanotube-joining technique should be useful not only for the construction of multifunctional hybrid nanotubes but also for the production of nanoreactors for chemical/biological reactions and nanodevices for analysis and separation.

  DOI：

  10.1246/bcsj.20190046

文献信息

• [EN] GLYCOLIPID COMPOUNDS AND THEIR USES IN THE TREATMENT OF TUMOURS<br/>[FR] COMPOSÉS GLYCOLIPIDES ET LEURS UTILISATIONS DANS LE TRAITEMENT DE TUMEURS
  申请人：AGALIMMUNE LTD

  公开号：WO2017082753A1

  公开（公告）日：2017-05-18

  The invention relates to novel glycolipid compounds and pharmaceutical compositions comprising said glycolipids and to processes for preparing said glycolipids. The invention also relates to said glycolipids for use in treating tumours and methods of treating tumours using said glycolipids.

  该发明涉及新型糖脂类化合物和包含所述糖脂类化合物的药物组合物，以及制备所述糖脂类化合物的方法。该发明还涉及利用所述糖脂类化合物治疗肿瘤以及利用所述糖脂类化合物治疗肿瘤的方法。
• Peripherally selective piperidine carboxylate opioid antagonists
  申请人：Eli Lilly and Company

  公开号：US05250542A1

  公开（公告）日：1993-10-05

  3,4,4-trisubstitutedpiperidinyl-N-alkylcarboxylates and intermediates for their preparation are provided. These piperidine-N-alkylcarboxylates are useful as peripheral opioid antagonists.

  提供了3,4,4-三取代哌啶基-N-烷基羧酸酯及其制备中间体。这些哌啶-N-烷基羧酸酯可用作周围阿片受体拮抗剂。
• Thiadiazoline derivative
  申请人：Murakata Chikara

  公开号：US20070112044A1

  公开（公告）日：2007-05-17

  An antitumor agent comprising a thiadiazoline derivative represented by the general formula (I), or a pharmacologically acceptable salt thereof as an active ingredient: (wherein Z represents a sulfur atom and the like, R 1 represents substituted or unsubstituted lower alkynyl and the like, R 2 represents a hydrogen atom and the like, R 3 represents substituted or unsubstituted lower alkyl and the like, and R 4 represents substituted or unsubstituted aryl and the like), and the like are provided.

  一种抗肿瘤剂，包括由通式（I）表示的噻二唑衍生物或其药学上可接受的盐作为活性成分：（其中Z代表硫原子等，R1代表取代或未取代的较低炔基等，R2代表氢原子等，R3代表取代或未取代的较低烷基等，R4代表取代或未取代的芳基等）等。
• Hiv Integrase Inhibitors
  申请人：Wai John S.

  公开号：US20080287394A1

  公开（公告）日：2008-11-20

  Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  羟基取代的吡嗪吡咯吡啶二酮化合物是HIV整合酶的抑制剂和HIV复制的抑制剂。在一种实施例中，二酮化合物是公式（I）中的化合物，其中R1，R2，R3，R4，R5，R6和R7在此被定义。这些化合物对于预防和治疗HIV感染以及预防、延缓和治疗艾滋病非常有用。这些化合物作为化合物本身或作为药物可接受的盐的形式用于对抗HIV感染和艾滋病。这些化合物及其盐可以作为药物组成部分使用，可选地与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。
• HIV integrase inhibitors
  申请人：Merck & Co., Inc.

  公开号：US07538112B2

  公开（公告）日：2009-05-26

  Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  羟基取代的吡嗪吡咯吡啶二酮化合物是HIV整合酶的抑制剂和HIV复制的抑制剂。在一种实施方式中，二酮化合物为式(I)的化合物，其中R1、R2、R3、R4、R5、R6和R7如本文所定义。这些化合物可用于预防和治疗HIV感染，并用于预防、延缓发病和治疗艾滋病。这些化合物可作为化合物本身或以药学上可接受的盐的形式用于抗击HIV感染和艾滋病。这些化合物及其盐可作为制药组合物的成分，可选地与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。