2-氨基-4-苯基-5-噻唑甲酸乙酯盐酸盐 | 53266-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-氨基-4-苯基-5-噻唑甲酸乙酯盐酸盐
• 中文别名: 2-氨基-4-甲基噻唑-5-甲酸乙酯盐酸盐；2-氨基-4-苯基-5-噻唑甲酸乙酯
• 英文名称: 2-amino-4-methyl-thiazole-5-carboxylic acid ethyl ester; hydrochloride
• 英文别名: 2-amino-4-methyl-thiazole-5-carboxylic acid ethyl ester; monohydrochloride；2-Amino-4-methyl-thiazol-5-carbonsaeure-aethylester; Monohydrochlorid；ethyl 2-amino-4-methylthiazole-5-carboxylate hydrochloride；ethyl 2-amino-4-methyl-1,3-thiazole-5-carboxylate;hydrochloride
• CAS: 53266-92-5
• 化学式: C₇H₁₀N₂O₂S*ClH
• mdl: MFCD00829075
• 分子量: 222.696
• InChiKey: DCTXAUJLGMDHAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  216-217 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  1.11
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  93.4
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 安全说明：
  S24/25
• 海关编码：
  2934100090

SDS

Name:	Ethyl 2-amino-4-methyl-1 3-thiazole-5-carboxylate hydrochloride tech Material Safety Data Sheet
Synonym:
CAS:	53266-92-5

Section 1 - Chemical Product MSDS Name:Ethyl 2-amino-4-methyl-1 3-thiazole-5-carboxylate hydrochloride tech Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
53266-92-5	Ethyl 2-amino-4-methyl-1,3-thiazole-5-		unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 53266-92-5: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 215 deg C(decom)
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H11ClN2O2S
Molecular Weight: 222.7

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 53266-92-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Ethyl 2-amino-4-methyl-1,3-thiazole-5-carboxylate hydrochloride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 53266-92-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 53266-92-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 53266-92-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氨基-4-苯基-5-噻唑甲酸乙酯盐酸盐 、 对氰基苯甲酰氯 在 盐酸 、 水 作用下， 以 吡啶 为溶剂， 反应 1.17h， 以to give ethyl 2-(4-cyanobenzoylamino)-4-methylthiazole-5-carboxylate (262.0 g)的产率得到ethyl 2-(4-cyanobenzoylamino)-4-methylthiazole-5-carboxylate
  参考文献：
  名称：

  Thiazoline derivatives

  摘要：

  一种噻唑啉衍生物，其化学式为：##STR1## [其中R.sup.1为氰基、氨基甲酰基、硫氨基甲酰基、吗啉硫氨基甲酰基、烷基硫代亚咪唑基、氨基亚胺基、取代氨基亚胺基或咪唑啉-2-基，R.sup.2为烷基或芳基烷基，R.sup.3为氢或烷基，R.sup.4为羟基、烷氧基、取代烷氧基或氨基，l为1至5的整数]及其盐具有纤维蛋白原受体拮抗和细胞黏附因子拮抗作用，并可用作缺血性疾病和动脉硬化疾病的治疗剂以及肿瘤转移抑制剂。

  公开号：

  US05478945A1

文献信息

• Imtiaz Husain; Nasir, Journal of the Indian Chemical Society, 1976, vol. 53, # 3, p. 305 - 306
  作者：Imtiaz Husain、Nasir

  DOI：——

  日期：——
• THIAZOLINE DERIVATIVE
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0649843B1

  公开（公告）日：2000-09-06
• US5478945A
  申请人：——

  公开号：US5478945A

  公开（公告）日：1995-12-26