N-cyclohexyl-5,14-dioxo-5,14,18b,18c-tetrahydrobenzo[g]diisoindolo[2,1-a:1',2'-c]quinoxaline-18b-carboxamide | 1341221-18-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-cyclohexyl-5,14-dioxo-5,14,18b,18c-tetrahydrobenzo[g]diisoindolo[2,1-a:1',2'-c]quinoxaline-18b-carboxamide
• 英文别名: N-cyclohexyl-3,18-dioxo-2,19-diazaheptacyclo[18.8.0.02,10.04,9.011,19.012,17.022,27]octacosa-1(28),4,6,8,12,14,16,20,22,24,26-undecaene-10-carboxamide
• CAS: 1341221-18-8
• 化学式: C₃₃H₂₇N₃O₃
• 分子量: 513.596
• InChiKey: PHQWBVOPDAKPLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  39
• 可旋转键数：
  2
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异氰环已烷 、 2,3-二氨基萘 、 邻羧基苯甲醛 以 甲醇 为溶剂， 反应 48.0h， 以87%的产率得到N-cyclohexyl-5,14-dioxo-5,14,18b,18c-tetrahydrobenzo[g]diisoindolo[2,1-a:1',2'-c]quinoxaline-18b-carboxamide
  参考文献：
  名称：

  A novel one-pot pseudo-four-component isocyanide-based reaction: an unexpected approach for the synthesis of tetrahydrodiisoindoloquinoxalines and tetrahydrobenzodiisoindoloquinoxalines

  摘要：

  A novel isocyanide based one-pot pseudo-four-component strategy for the synthesis of tetrahydrodiisoindoloquinoxaline and tetrahydrobenzodiisoindoloquinoxaline derivatives via the reaction of 1,2-diamines, 2-formylbenzoic acid, and an isocyanide at room temperature in good yields without using any catalyst and activation, is described. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.08.061

文献信息

• A novel one-pot pseudo-four-component isocyanide-based reaction: an unexpected approach for the synthesis of tetrahydrodiisoindoloquinoxalines and tetrahydrobenzodiisoindoloquinoxalines
  作者：Ahmad Shaabani、Fatemeh Hajishaabanha、Mojtaba Mahyari、Hamid Mofakham、Seik Weng Ng

  DOI：10.1016/j.tet.2011.08.061

  日期：2011.10

  A novel isocyanide based one-pot pseudo-four-component strategy for the synthesis of tetrahydrodiisoindoloquinoxaline and tetrahydrobenzodiisoindoloquinoxaline derivatives via the reaction of 1,2-diamines, 2-formylbenzoic acid, and an isocyanide at room temperature in good yields without using any catalyst and activation, is described. (C) 2011 Elsevier Ltd. All rights reserved.