cyclooctanesulfonic acid | 135469-39-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: cyclooctanesulfonic acid
• CAS: 135469-39-5
• 化学式: C₈H₁₆O₃S
• 分子量: 192.279
• InChiKey: IWLITGVUOGGPDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  环辛烷 在 bis(acetylacetonate)oxovanadium 二氧化硫 、 氧气 、 溶剂黄146 作用下， 40.0 ℃ 、101.1 kPa 条件下， 反应 5.0h， 以45%的产率得到cyclooctanesulfonic acid
  参考文献：
  名称：

  PROCESS FOR PREPARING ORGANIC SULFUR ACIDS OR SALTS THEREOF

  摘要：

  公开号：

  EP1188743B1

文献信息

• [EN] LANTHIONINE C-LIKE PROTEIN 2 LIGANDS, CELLS PREPARED THEREWITH, AND THERAPIES USING SAME<br/>[FR] LIGANDS DE LA PROTÉINE 2 DE TYPE LANTHIONINE C, CELLULES PRÉPARÉES AVEC CEUX-CI, ET THÉRAPIES LES UTILISANT
  申请人：LANDOS BIOPHARMA INC

  公开号：WO2021127472A1

  公开（公告）日：2021-06-24

  Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including autoimmune diseases, inflammatory diseases, chronic inflammatory diseases, diabetes, and infectious diseases, such as lupus, rheumatoid arthritis, type 1 diabetes, inflammatory bowel disease, viral diseases, and nonalcoholic steatohepatitis. The compounds can also be used to generate cells, such as immune cells, for treating the conditions.

  提供的是靶向兰硫氨酸合成酶C样蛋白2途径的化合物。这些化合物可用于治疗多种疾病，包括自身免疫性疾病、炎症性疾病、慢性炎症性疾病、糖尿病和传染性疾病，如狼疮、类风湿性关节炎、1型糖尿病、炎症性肠病、病毒性疾病和非酒精性脂肪肝炎。这些化合物还可用于生成细胞，如免疫细胞，以治疗这些疾病。
• Process for preparing organic sulfur acids or salts thereof
  申请人：——

  公开号：US20020161255A1

  公开（公告）日：2002-10-31

  A process for producing organic sulfur acid or a salt thereof of the present invention allows an organic substrate to react with a sulfur oxide in the presence of a metallic compound catalyst and in the absence of N-hydroxy and N-oxo cyclic imide compounds and thereby yields a corresponding organic sulfur acid or a salt thereof. Such organic substrates include, for example, (a) homocyclic or heterocyclic compounds having a methylene group, (b) compounds having a methine carbon atom, (c) compounds having a methyl group or methylene group at the adjacent position to an unsaturated bond, (d) non-aromatic heterocyclic compounds having a carbon-hydrogen bond at the adjacent position to a hetero atom, and (e) straight-chain alkanes. The sulfur oxide includes, for example, sulfur dioxide. This production process can efficiently produce an organic sulfur acid or a salt thereof under mild conditions.

  本发明的有机硫酸或其盐的生产方法允许有机底物在金属化合物催化剂存在下与硫氧化物反应，而无需N-羟基和N-氧代环亚酰胺化合物，并因此产生相应的有机硫酸或其盐。这样的有机底物包括，例如，(a) 具有亚甲基基团的同环或异环化合物，(b) 具有亚甲基碳原子的化合物，(c) 在不饱和键相邻位置具有甲基基团或亚甲基基团的化合物，(d) 具有相邻位置至杂原子处的碳氢键的非芳香杂环化合物，以及(e) 直链烷烃。硫氧化物包括，例如，二氧化硫。这种生产方法可以在温和条件下高效地生产有机硫酸或其盐。
• [EN] PLXDC2 LIGANDS<br/>[FR] LIGANDS DE PLXDC2
  申请人：LANDOS BIOPHARMA INC

  公开号：WO2021195360A1

  公开（公告）日：2021-09-30

  Provided are compounds that target plexin domain containing 2 (PLXDC2). The compounds can be used to treat conditions such as inflammatory or immune-mediated diseases, diabetes, infectious diseases, and cancers. The compounds can be used to treat such specific conditions as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, autoimmune encephalitis, diabetic nephropathy, diabetic retinopathy, psoriasis, and inflammatory bowel disease, among other conditions.

  提供了针对含有plexin结构域2（PLXDC2）的化合物。这些化合物可以用于治疗炎症或免疫介导性疾病、糖尿病、传染病和癌症等疾病。这些化合物可以用于治疗系统性红斑狼疮、类风湿关节炎、多发性硬化症、自身免疫性脑炎、糖尿病肾病、糖尿病视网膜病变、银屑病和炎症性肠病等特定疾病。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF
  申请人：NAKAI Hisao

  公开号：US20100063104A1

  公开（公告）日：2010-03-11

  It is intended to provide a compound represented by the formula (I): wherein all the symbols are as defined in the description; which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.

  本发明旨在提供一种由公式（I）表示的化合物：其中所有符号如描述中所定义的；其具有p38 MAP激酶抑制活性，其盐，其N-氧化物，其溶剂合物或其前药。本发明的化合物可用于预防或治疗疾病，其中被认为异常产生细胞因子如炎症性细胞因子或趋化因子或对它们过度反应与病理情况的发生和加重有关，换句话说，是细胞因子介导的疾病，例如炎症性疾病，呼吸系统疾病，心血管疾病，中枢神经系统疾病或类似疾病。
• 3-ALKOXY-1-PHENYLPYRAZOLE DERIVATIVES AND PESTICIDES
  申请人：Ohata Satoru

  公开号：US20100210704A1

  公开（公告）日：2010-08-19

  To provide pesticides such as insecticides, miticides and nematicides, which are excellent in the safety, pesticidal effects, residual effectiveness, etc., which further have infiltration, and which can be applied by soil treatment. A pesticide comprising a 3-alkoxy-1-phenyl-pyrazole derivative represented by the formula [I] or an agriculturally acceptable salt thereof as an active ingredient: wherein, for example, R 1 is a C 1 -C 10 alkyl group or the like, R 2 is a hydrogen atom or the like, R 3 is a hydrogen atom or the like, and each of R 4 , R 5 , R 6 and R 8 which are independent of one another, is a hydrogen atom or the like, and R 7 is a C 2 -C 4 haloalkylthio group or the like.

  提供杀虫剂，如杀虫剂，杀螨剂和杀线虫剂，这些杀虫剂在安全性、杀虫效果、残留效果等方面都非常出色，而且具有渗透性，可以通过土壤处理应用的杀虫剂。该杀虫剂包括以下公式[I]所表示的3-烷氧基-1-苯基-吡唑烷衍生物或其农业上可接受的盐作为活性成分：其中，例如，R1是C1-C10烷基或类似物，R2是氢原子或类似物，R3是氢原子或类似物，而且独立于彼此的R4、R5、R6和R8是氢原子或类似物，而R7是C2-C4卤代烷基硫基或类似物。