1-(1-indanyl)piperidine | 62687-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1-(1-indanyl)piperidine
• 英文别名: 1-(1-Indanoyl)piperidin；1-(2,3-Dihydro-1H-inden-1-yl)piperidine
• CAS: 62687-79-0
• 化学式: C₁₄H₁₉N
• 分子量: 201.312
• InChiKey: AGECZFKPNRSRDG-UHFFFAOYSA-N

物化性质

• 沸点：
  295.1±9.0 °C(Predicted)
• 密度：
  1.061±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  哌啶 、 1-茚酮 在 sodium hydroxide 、 sodium borohydrid 、 对甲苯磺酸 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 生成 1-(1-indanyl)piperidine
  参考文献：
  名称：

  Diene intermediates for indantetrol derivatives

  摘要：

  提供具有结构##SPC1##的化合物 其中n为1、2或3，m和m'为0、1或2，R.sub.1、R.sub.2、R.sub.3和R.sub.4可以相同也可以不同，可以是氢、低烷基、卤代低烷基、酰基、低烷氧羰基##EQU1## 酰胺##EQU2## 或低烷氧基烷基，X为直链或支链二价脂肪族基团，Y为##EQU3## 这些化合物在治疗高血压方面很有用。

  公开号：

  US03984407A1
• 作为试剂：
  描述：

  1-茚酮 、 哌啶 、 甲苯 、 对甲苯磺酸 在 哌啶 、 硼氢化钠 、 溶剂黄146 、 sodium hydroxide 、 水 、 甲醇 、 乙醚 、 氢氧化钾 、 1-(1-indanyl)piperidine 作用下， 以 水 为溶剂， 反应 48.0h， 生成 1-(1-indanyl)piperidine
  参考文献：
  名称：

  4,7-Dihydroindanyl alkanols, analogues thereof and their corresponding

  摘要：

  提供具有以下结构的化合物：##STR1## 其中N为1、2或3，M和M'为0、1或2，R.sub.1、R.sub.2、R.sub.3和R.sub.4可以相同或不同，可以是氢、低烷基、卤代低烷基、酰基、低烷氧基-羰基##STR2## 或低烷氧基烷基，X为直链或支链双价脂肪族基，Y为##STR3## 这些化合物在治疗高血压方面有用。

  公开号：

  US04044040A1

文献信息

• [EN] PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS<br/>[FR] DERIVES DE PYRROLIDINE UTILISES EN TANT QU'ANTAGONISTES DE L'OXYTOCINE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2004005249A1

  公开（公告）日：2004-01-15

  The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R1 is selected from the group comprising or consisting of H and C1-C6-alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea.

  本发明涉及公式（I）的新型吡咯烷衍生物，其几何异构体，其光学活性形式如对映体，非对映体，这些的混合物及其外消旋形式，以及其盐，其中R1选自包括或由H和C1-C6-烷基组成的群，用于预防和/或治疗早产、早产或痛经。
• Pharmaceutically active sulfanilide derivatives
  申请人：——

  公开号：US20040072816A1

  公开（公告）日：2004-04-15

  The present invention relates to sulfanilide derivatives of formula (I), in which R 1 and R 2 are optionally substituted aryl and heteroaryl groups and the other variables are as defined in the claims, for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such sulfanilide derivatives. Said derivatives are useful in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. In particular, the present invention is related to sulfanilide derivatives displaying a substantial modulatory, in particular antagonistic activity, of the oxytocin and/or vasopressin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin and/or vasopressin, including preterm labor, premature birth, dysmenorrhea, inappropriate secretion of vasopressin, congestive heart failure, arterial hypertension, liver cirrhosis, nephrotic syndrome and ocular hypertension. The present invention is furthermore related to novel sulfanilide derivatives as well as to methods of their preparation.

  本发明涉及式(I)的磺胺基苯酰胺衍生物，其中R1和R2是可选择取代的芳基和杂环芳基基团，其他变量如权利要求中所定义，用作药用活性化合物，以及含有这种磺胺基苯酰胺衍生物的药物配方。所述衍生物在治疗和/或预防早产、早产、痛经、抗利尿素分泌不当、充血性心力衰竭、动脉高血压、肝硬化、肾病综合征和眼压增高方面具有用途。具体而言，本发明涉及显示对催产素和/或抗利尿素受体具有显著调节作用，特别是拮抗活性的磺胺基苯酰胺衍生物。更具体地说，所述化合物在治疗和/或预防由催产素和/或抗利尿素介导的疾病状态方面具有用途，包括早产、早产、痛经、抗利尿素分泌不当、充血性心力衰竭、动脉高血压、肝硬化、肾病综合征和眼压增高。本发明还涉及新型磺胺基苯酰胺衍生物以及其制备方法。
• Pharmaceutically active pyrrolidine derivatives
  申请人：——

  公开号：US20030212012A1

  公开（公告）日：2003-11-13

  The present invention is related to pyrrolidine derivatives of formula (I). Said 1 compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention of premature labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including premature labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation, wherein X is selected from the group consisting of CR6R7, NOR6, NNR6R7; A is selected from the group consisting of —(C═O)—, —(C═O)—O—, —C(═NH)—, —(C═O)—NH—, —(C═S)—NH, —SO22—, —SO2NH—, —CH2—,B is either a group —(C═O)—NR8R9 or represents a heterocyclic residue having the formula (a) wherein Q is NR10, O or S; n is an integer selected of 0, 1 or 2; Y, Z and E form together with the 2 carbons to which they are attached a 5-6 membered aryl or heteroaryl ring.

  本发明涉及式(I)的吡咯烷衍生物。所述化合物优选用作药用活性化合物。具体而言，式(I)的吡咯烷衍生物在治疗和/或预防早产、早产和痛经方面是有用的。特别是，本发明涉及显示出氧催产素受体显著调节作用，特别是拮抗剂活性的吡咯烷衍生物。更具体地，所述化合物在治疗和/或预防由氧催产素介导的疾病状态，包括早产、早产和痛经方面是有用的。本发明还涉及新型吡咯烷衍生物以及其制备方法，其中X从CR6R7、NOR6、NNR6R7组中选择；A从—(C═O)—、—(C═O)—O—、—C(═NH)—、—(C═O)—NH—、—(C═S)—NH、—SO22—、—SO2NH—、—CH2—中选择；B是一个群—(C═O)—NR8R9或表示具有式(a)的杂环残基，其中Q是NR10、O或S；n是选择的整数0、1或2；Y、Z和E与它们连接的2个碳一起形成一个5-6成员芳基或杂芳基环。
• [EN] NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES UTILISÉS COMME INHIBITEURS DE ERK
  申请人：MERCK SHARP & DOHME

  公开号：WO2011163330A1

  公开（公告）日：2011-12-29

  The present invention provides a compound of the Formula I:(Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

  本发明提供了一种化合物，其化学式为I：（此处应插入化学式 I），或其药用可接受的盐、溶剂或酯，其中 R、R1、R2 和 R3 如本文所定义。这些化合物是 ERK 抑制剂。还公开了包括上述化合物的药物组合物以及使用它们治疗癌症的方法。
• DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
  申请人：——

  公开号：US20030082623A1

  公开（公告）日：2003-05-01

  This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention provides a method of modifying the feeding behavior of a subject which comprises administering to the subject an amount of an MCH1 antagonist effective to decrease the body mass of the subject and/or decrease the consumption of food by the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's depression and/or anxiety.

  这项发明提供了编码人类MCH1受体的孤立核酸，纯化的人类MCH1受体，包括编码人类MCH1受体的孤立核酸的载体，包含这种载体的细胞，针对人类MCH1受体的抗体，用于检测编码人类MCH1受体的核酸探针，互补于编码人类MCH1受体独特序列的反义寡核苷酸，表达编码正常或突变人类MCH1受体的转基因非人类动物，孤立人类MCH1受体的分离方法，治疗与人类MCH1受体活性相关的异常的方法，以及确定化合物与哺乳动物MCH1受体结合的方法。这项发明提供了一种修改受试者摄食行为的方法，包括向受试者投与足以减少受试者体重和/或减少受试者食物摄入量的MCH1拮抗剂的量。这项发明还提供了一种治疗患有抑郁和/或焦虑的受试者的方法，包括向受试者投与足以治疗受试者抑郁和/或焦虑的MCH1拮抗剂的量。