2-氨基-6-氯-α-氰基-3-（乙氧羰基）-4H-1-苯并吡喃-4-乙酸乙酯 | 305834-79-1

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 2-氨基-6-氯-α-氰基-3-（乙氧羰基）-4H-1-苯并吡喃-4-乙酸乙酯
• 中文别名: 2-氨基-6-氯-ALPHA-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯；AKT磷酸化激活剂(SC79)
• 英文名称: ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
• CAS: 305834-79-1
• 化学式: C₁₇H₁₇ClN₂O₅
• 分子量: 364.8
• InChiKey: DXVKFBGVVRSOLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Nato3 mutant polypeptides and uses thereof
  申请人：Grand Valley State University

  公开号：US11111279B2

  公开（公告）日：2021-09-07

  The present invention relates to isolated Nato3 mutant polypeptides. Methods for stimulating a brain cell to differentiate into a dopaminergic progenitor neuronal cell or a dopaminergic neuron comprises increasing phosphorylation of Nato3 in the brain cells and culturing the brain cells until a progenitor dopaminergic neuronal cell marker or a dopaminergic neuronal cell marker is expressed in the cultured brain cells. Methods for treating Parkinson's disease (PD) in a subject comprises administering to the subject in need thereof, a composition comprising progenitor dopaminergic neuronal cells and/or dopaminergic neuronal cells expressing a Nato3 mutant polypeptide to the brain of the subject.

  本发明涉及分离的Nato3突变体多肽。刺激脑细胞分化成多巴胺能祖细胞或多巴胺能神经元的方法包括增加脑细胞中 Nato3 的磷酸化，培养脑细胞，直到在培养的脑细胞中表达多巴胺能祖细胞标记或多巴胺能神经元标记。治疗受试者帕金森病（PD）的方法包括向有需要的受试者施用一种组合物，该组合物包括向受试者的大脑施用表达Nato3突变体多肽的原代多巴胺能神经元细胞和/或多巴胺能神经元细胞。
• COMPOSITIONS FAVORING WOUND REPAIR
  申请人：Université Laval

  公开号：EP3370717B1

  公开（公告）日：2021-01-06
• PROMOTION OF EPITHELIAL REPAIR VIA THE ADMINISTRATION OF ACTIVATORS OF PI3K/AKT SIGNALLING
  申请人：Telethon Kids Institute

  公开号：EP3796918A1

  公开（公告）日：2021-03-31
• METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS
  申请人：Kartos Therapeutics, Inc.

  公开号：EP3801476A2

  公开（公告）日：2021-04-14
• NATO3 MUTANT POLYPEPTIDES AND USES THEREOF
  申请人：Grand Valley State University

  公开号：US20180346530A1

  公开（公告）日：2018-12-06

  The present invention relates to isolated Nato3 mutant polypeptides. Methods for stimulating a brain cell to differentiate into a dopaminergic progenitor neuronal cell or a dopaminergic neuron comprises increasing phosphorylation of Nato3 in the brain cells and culturing the brain cells until a progenitor dopaminergic neuronal cell marker or a dopaminergic neuronal cell marker is expressed in the cultured brain cells. Methods for treating Parkinson's disease (PD) in a subject comprises administering to the subject in need thereof, a composition comprising progenitor dopaminergic neuronal cells and/or dopaminergic neuronal cells expressing a Nato3 mutant polypeptide to the brain of the subject.