4-benzenesulfonyl-5-ethoxy-2-phenyloxazole | 146377-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-benzenesulfonyl-5-ethoxy-2-phenyloxazole
• 英文别名: 4-(Benzenesulfonyl)-5-ethoxy-2-phenyl-1,3-oxazole
• CAS: 146377-57-3
• 化学式: C₁₇H₁₅NO₄S
• 分子量: 329.376
• InChiKey: FXSPBWLHEFPURE-UHFFFAOYSA-N

物化性质

• 沸点：
  538.2±60.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯砜乙酸乙酯 在 rhodium(II) acetate dimer 4-乙酰氨基苯磺酰叠氮 、 三乙胺 作用下， 以 氯仿 、 乙腈 为溶剂， 反应 17.0h， 生成 4-benzenesulfonyl-5-ethoxy-2-phenyloxazole
  参考文献：
  名称：

  The rhodium carbenoid route to oxazoles. Synthesis of 4-functionalised oxazoles; Three step preparation of a bis-oxazole

  摘要：

  Oxazole-4-sulfones, -phosphonates, and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound, The effect of the ligand on rhodium was briefly investigated, with rhodium(II) trifluoroacetamide generally proving the most effective catalyst. The 4-cyanooxazole 9 is readily converted into the bis-oxazoles 10-12.

  DOI：

  10.1016/s0040-4020(01)90396-5

文献信息

• Diazo-sulfones and -nitriles in oxazole synthesis; three step preparation of a bis-oxazole
  作者：Kevin J. Doyle、Christopher J. Moody

  DOI：10.1016/0040-4039(93)88041-g

  日期：1992.12

  Oxazole-4-sulfones and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound: the 4-cyarkooxazole 3 is readily converted into the bis-oxazoles 4 and S.
• The rhodium carbenoid route to oxazoles. Synthesis of 4-functionalised oxazoles; Three step preparation of a bis-oxazole
  作者：Kevin J. Doyle、Christopher J. Moody

  DOI：10.1016/s0040-4020(01)90396-5

  日期：1994.3

  Oxazole-4-sulfones, -phosphonates, and -nitriles are prepared by rhodium(II) catalysed addition of nitriles to the corresponding diazo compound, The effect of the ligand on rhodium was briefly investigated, with rhodium(II) trifluoroacetamide generally proving the most effective catalyst. The 4-cyanooxazole 9 is readily converted into the bis-oxazoles 10-12.