2,4-di-tert-butyl-5-methyl-anisole | 874521-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-di-tert-butyl-5-methyl-anisole
• 英文别名: Methyl-(3-methyl-4.6-di-tert.-butyl-phenyl)-aether；5-Methoxy-1-methyl-2.4-di-tert.-butyl-benzol；2,4-Di-tert-butyl-5-methyl-anisol；1,5-Ditert-butyl-2-methoxy-4-methylbenzene
• CAS: 874521-29-6
• 化学式: C₁₆H₂₆O
• 分子量: 234.382
• InChiKey: PJRSNKGKFATQBN-UHFFFAOYSA-N

物化性质

• 熔点：
  60-62 °C(Solv: ethanol (64-17-5))
• 沸点：
  108 °C(Press: 3.5 Torr)
• 密度：
  0.890±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-di-tert-butyl-5-methyl-anisole 在 硝酸 、 乙酸酐 、 溶剂黄146 作用下， 生成 4,6-di-tert-butyl-3-methyl-2-nitro-anisole
  参考文献：
  名称：

  Lurje, Zhurnal Obshchei Khimii, 1946, vol. 16, p. 145,154

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁烯 、 间甲基苯甲醚 在 三氯化铝 作用下， 生成 2,4-di-tert-butyl-5-methyl-anisole
  参考文献：
  名称：

  Lurje, Zhurnal Obshchei Khimii, 1946, vol. 16, p. 145,154

  摘要：

  DOI：

文献信息

• Photoinduced reactions—XXXVII
  作者：K. Ogura、T. Matsuura

  DOI：10.1016/s0040-4020(01)97841-x

  日期：1970.1

  Irridiation of 2,4,6-tri-t-butyl-3-methoxy-2,5-cyclohexadienone (III) in benzene afforded 3,6-di-t-butylguaiacol (II) and a benzocyclobutene (V) in high yields. The ratio of II to V depends on the wavelength of the incident light and decreases on irradiation with light of shorter wavelengths. Furthermorre, V was formed the faster in the order of the wavelengths of the incidents light: 361 ± 7, 325

  2,4,6-三叔丁基-3-甲氧基-2,5-环己二酮在苯中的铱化反应可高收率得到3,6-二叔丁基愈创木酚（II）和苯并环丁烯（V） 。II与V之比取决于入射光的波长，并且在用较短波长的光照射时减小。更进一步地，按照入射光的波长顺序更快地形成了V：361±7、325±7和289±mμ。这些事实表明，III的m，π *激发主要负责II的形成，而π，π *激发主要负责V的形成。讨论了这些现象的可能解释。
• US1926080
  申请人：——

  公开号：——

  公开（公告）日：——
• 2, 4-di-tertiary-butyl-5-methoxy benzaldehyde
  申请人：BURTON T BUSH INC

  公开号：US02450879A1

  公开（公告）日：1948-10-12
• Polycationic Compounds And Uses Thereof
  申请人：Mousa Shaker

  公开号：US20110124664A1

  公开（公告）日：2011-05-26

  Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
• POLYCATIONIC COMPOUNDS AND USES THEREOF
  申请人：Mousa Shaker

  公开号：US20140051762A1

  公开（公告）日：2014-02-20

  Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.